Inflammatory Indices and MAFLD Prevalence in Hypertensive Patients: A Large-Scale Cross-Sectional Analysis from China

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1623 - 1638

Published: Feb. 1, 2025

Objective: Hypertension development and progression are largely influenced by inflammation, which plays a critical role activating the immune system causing damage to vascular endothelium. Metabolic dysfunction-associated fatty liver disease (MAFLD) is also associated with chronic low-grade drives via metabolic imbalances adipose tissue dysfunction. This study investigates relationship between inflammatory indices MAFLD in hypertensive patients assesses predictive accuracy of these for MAFLD. Methods: We performed cross-sectional analysis involving 34,303 from Chinese hospital-based registry. The diagnosis was established using dysfunction criteria alongside evidence hepatic steatosis confirmed through imaging. Complete blood counts were used calculate indices, including monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), systemic response index (SIRI), immune-inflammation (SII), aggregate inflammation (AISI). To assess MAFLD, multivariable logistic regression adjustments potential confounders. diagnostic performance analyzed receiver operating characteristic (ROC) curves area under curve (AUC) calculations. Results: Patients exhibited significantly elevated levels all compared those without. After adjustment, each standard deviation increase AISI, SIRI, SII 74%, 62%, 58% increased odds respectively. AUC AISI 0.659, indicating moderate accuracy. AUCs SIRI 0.626 0.619, respectively, while NLR, PLR, MLR had lower 0.593, 0.558, 0.589, Conclusion: In patients, especially show strong association their utility risk stratification within clinical settings. Further research needed evaluate effectiveness markers management Keywords: metabolic-dysfunction-associated disease, hypertension,

Language: Английский

---

Temporal trends in the planetary health diet index and its association with cardiovascular, kidney, and metabolic diseases: A comprehensive analysis from global and individual perspectives

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(5), P. 100520 - 100520

Published: Feb. 21, 2025

Diet plays a critical role in human health and environmental sustainability, particularly cardiovascular, kidney, metabolic (CKM) diseases. However, the variations Planetary Health Index (PHDI) across populations, regions, over time, as well its association with CKM disease burdens, remain insufficiently explored. We assessed PHDI scores using data from 185 countries (1990-2018) Global Dietary Database, examining demographic characteristics temporal trends. The Burden of Disease Study was used to evaluate associations between including incidence, prevalence, mortality, disability-adjusted life years. syndrome defined by American Heart Association. Individual-level National Nutrition Examination Survey (NHANES) were also assess impact on risks mortality. From 1990 2018, while overall remained relatively stable sexes, composition shifted different age groups. In mean score 42.80 (95% uncertainty interval [UI] 42.49-46.50) for males 44.65 UI 44.53-47.82) females. Higher observed among females, older adults, urban residents, individuals higher education, those South Asia. Globally, consumption red/processed meat, saturated oils/trans fats, added sugars substantially exceeded EAT-Lancet Commission's reference values. generally associated lower although these varied subtype. individual-level analysis, 45,460 NHANES participants (weighted age: 47.21 years, 51.4% female), each 10-point increase linked 13.7% reduction stage 3/4 risk, an 11.1% 4 incidences mortality rates cardiovascular diseases, chronic kidney disease. significant changes occurred components PHDI, notable demographics region. may reduce warranting further investigation into specific subtypes.

Language: Английский

---

EAT-Lancet Diet Pattern, genetic risk, and risk of colorectal cancer: a prospective study from the UK Biobank

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

---

Food for thought: The EAT-Lancet diet to prevent a fatty liver

Hepatology, Journal Year: 2025, Volume and Issue: 81(5), P. 1392 - 1393

Published: April 18, 2025

Language: Английский

---