The Influence of Lifestyle Modifications on Cardiovascular Outcomes in Older Adults: Findings from a Cross-Sectional Study

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 87 - 87

Published: Jan. 13, 2025

Background: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among older adults. Lifestyle modifications, including diet, physical activity, smoking cessation, are key to reducing cardiovascular risk. This study examines the combined effects these behaviors on outcomes their mediating mechanisms. Methods: A cross-sectional was conducted adults (aged ≥ 60 years) in Riyadh, Saudi Arabia. Data dietary quality, status were collected using validated questionnaires. outcomes, low-density lipoprotein cholesterol (LDL), systolic blood pressure (SBP), body mass index (BMI), measured. composite risk score computed. Path analysis employed assess direct indirect lifestyle factors outcomes. Results: Participants adhering healthy engaging regular avoiding had significantly lower scores. Non-smoking showed strongest effect (β = −0.20, p 0.006), while quality activity exhibited significant mediated by LDL, SBP, BMI. Combined adherence multiple resulted greatest reductions The path highlighted as critical mediators health improvements. Conclusions: modifications reduce adults, with cumulative benefits observed for behaviors. These findings emphasize importance comprehensive interventions targeting cessation promote aging populations.

Language: Английский

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Relevance of Lipoprotein Composition in Endothelial Dysfunction and the Development of Hypertension

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1125 - 1125

Published: Jan. 28, 2025

Endothelial dysfunction and chronic inflammation are determining factors in the development progression of degenerative diseases, such as hypertension atherosclerosis. Among shared pathophysiological characteristics these two diseases is a metabolic disorder lipids lipoproteins. Therefore, contents quality proteins lipoproteins become targets therapeutic objective. One stages lipoprotein formation occurs through incorporation dietary by enterocytes into chylomicrons. Consequently, composition, structure, especially properties could be modified intake bioactive compounds. The objective this review to describe roles different lipid protein components their receptors endothelial hypertension. In addition, we use some non-pharmacological treatments that improve function and/or prevent damage. reviewed information contributes understanding vehicles regulatory involved modulation inflammatory hemostatic processes, attenuation oxidative stress, neutralization toxins, rather than only cholesterol phospholipid transporters. For review, bibliographic search was carried out online metabases.

Language: Английский

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Unveiling the Silent Threat: Exploring Hypertension Prevalence and Risk Factors Among University Students in Syria

International Journal of Public Health, Journal Year: 2025, Volume and Issue: 70

Published: Feb. 3, 2025

Language: Английский

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Autonomous Epinephrine Release by KCNJ5 Mutation Drives Familial Thoracic Aortic Aneurysm and Dissection

Hypertension, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

BACKGROUND: The pathophysiology of familial thoracic aortic aneurysm and dissection (TAAD) is linked to genetic variants that affect components. Although hypertension a risk factor for TAAD, the precise link remains unclear. METHODS: A family with autosomal dominant TAAD complicated by was studied identify candidate mutations. effect identified mutation on development investigated using CRISPR-Cas9–generated knock-in mouse model elucidate mechanism underlying hypertension-induced TAAD. RESULTS: KCNJ5 p.R242Q in met criteria cosegregation, rarity, conservation. Utilizing our model, we observed significant proportion heterozygous mice displayed dilated aortas. mutation’s allele dose positively correlated incidence following β-aminopropionitrile monofumarate treatment. Pathological changes aorta, including collagen deposition dilation, elevated transforming growth factor-β activity, extracellular matrix remodeling, were associated hypertension. Furthermore, found induce lifelong isolated systolic hypertension, attributable autonomous epinephrine secretion from adrenal medulla. Unlike wild-type, mutated highly expressed medulla instead cortex. Treatment adrenergic β–receptor blocker propranolol reduced mitigated mice. CONCLUSIONS: Familial may stem dysfunction G-protein–coupling domain, causing via increased disruption homeostasis. These findings establish between

Language: Английский

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Moderate intensity continuous training, combined moderate-intensity continuous training vs combined high-intensity interval training in adults with hypertension: randomized controlled trial.

Complementary Therapies in Clinical Practice, Journal Year: 2025, Volume and Issue: 59, P. 101960 - 101960

Published: Feb. 13, 2025

Language: Английский

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The effectiveness of functional inspiratory muscle training on exercise capacity and peripheral muscle strength in patients with essential hypertension: a three-arm randomized controlled trial

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 28, 2025

Language: Английский

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The importance of dietary fibre

Medicína pro praxi, Journal Year: 2025, Volume and Issue: 22(1), P. E1 - E9

Published: Feb. 20, 2025

Language: Английский

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Non-high density lipoprotein cholesterol/high density lipoprotein cholesterol is L-shaped associated with all-cause mortality and U-shaped with cardiovascular mortality in hypertensive patients

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 13, 2025

Background Patients with hypertension may have better survival rates when their lipid metabolism is in balance. The relationship between the novel composite metric, NHHR, and all-cause cardiovascular mortality hypertensive patients remains unknown warrants further investigation. Methods We analyzed data from 5,561 participants National Health Nutrition Examination Survey (NHANES) spanning 1999 to 2018. To determine optimal NHHR cutoff point, we employed a maximum selection statistics approach. Participants were subsequently divided into groups for multivariate weighted Cox regression analysis. association risk was examined using restricted cubic splines (RCS). investigate possible variations among different populations, subgroup analysis interaction tests carried out. predictive capability of outcomes evaluated time-dependent receiver operating characteristic (ROC) curves. Results Over median follow-up period 93 months, exhibited an rate 21.78% 7.32%. A markedly elevated death associated levels below 1.66 (HR 1.76; 95% CI 1.31-2.38; P < 0.001), as well increased 1.58; 1.31-1.91; 0.001). RCS revealed U-shaped (P = 0.0083) L-shaped correlation 0.0001). Areas under curve (AUC) 0.97, 0.76, 0.87, 0.84, 0.80 3-year, 5-year, 10-year periods. Conclusions findings indicate that lower both mortality, highlighting critical need comprehensive management clinical hypertension. These results suggest could serve valuable tool identifying high-risk individuals should be incorporated routine stratification assessments patients. This more effectively improve patient prognosis guide personalized treatment strategies.

Language: Английский

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Effect of Remote Health Interventions on Blood Pressure Control and Quality of Life for Hypertension Self-management: A systematic review and meta-analysis

Research in Community and Public Health Nursing, Journal Year: 2025, Volume and Issue: 36, P. 150 - 150

Published: March 31, 2025

Objective: To evaluate the effect of remote health interventions on self-management hypertension. Methods: We systematically searched literature for studies published in English PubMed, Embase, Web Science, China National Knowledge Infrastructure (CNKI), and Cochrane Central Register Controlled Trials. The database was used to search relevant with full text hypertension versus usual care RevMan 5.4 data analysis. Results: A total 19 eventually met our inclusion criteria. results showed that group could significantly reduce levels SBP (MD=5.67, 95% CI=4.12-7.22, p<.001) DBP (MD=1.88, CI=1.16- 2.60, p<.001), compared group, it also improving patient's quality life (SMD=0.84, CI=0.32- 1.37, p=.002), waist circumference (MD=2.39, CI=0.35-4.44, p=.020) BMI (MD=0.49, CI=0.06-0.91, p=.020), increasing physical activity patients (SMD=0.19, CI=0.06- 0.31, p=.004). No obvious publication bias found this meta-analysis. Conclusion: This study can improve patients’ better BP control than care. Further be assess long-term clinical effectiveness economic evaluation self-management.

Language: Английский

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Прихильність до лікування пацієнтів на ішемічну хворобу серця з коморбідними станами: вплив соціально-економічних факторів під час воєнного стану в Україні (повідомлення перше)

Ukrainian Journal of Military Medicine, Journal Year: 2025, Volume and Issue: 6(1), P. 159 - 169

Published: March 31, 2025

Мета. Визначити впливу соціально-економічних факторів на прихильність до лікування пацієнтів ІХС з коморбідними захворюваннями в Україні під час війни. Матеріали і методи. На базі кафедри кардіології Національного університету охорони здоров'я України імені П.Л. Шупика було проведене дослідження за допомогою опитування та супутніми артеріальною гіпертензією, цукровим діабетом 2 типу, хронічною хворобою нирок онлайн-анкетування використанням Google Forms червня по вересень 2024 року. Використано методи систематизації, узагальнення, дедукції індукції, статистичні, бібліографічні. Результати. Визначено, що чоловіки більш прихильні ніж жінки (χ2=0,271, p=0,000 φ=0,271; p=0,006). Чоловіки однаково часто відмовляються від у разі покращення (χ2=0,468, φ=0,468, p=0,000) або погіршення (χ2=0,393, φ=0,393, стану самопочуття. Пацієнти, хворіють станами із одним/двома соціально-економічними факторами ризику (76,2% [76,2±0,04, p<0,0001]) мають найменшу лікування. Висновки. Прихильність війни залежить гендерних ознак: при покращенні/погіршенні здоров’я після розпочатого прийому Визначено статистичну достовірність одного-двох ризику. Запропоновано для розв’язання питань зменшення помилок прийомі фармакотерапії подальшого створювати мультидисциплінарні команди участю фармацевтів.

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