Inflammatory pain modifies reward preferences from larger delayed to smaller immediate rewards in male rats DOI Creative Commons
Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo

et al.

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138183 - 138183

Published: March 1, 2025

Self-control underlies goal-directed behavior in both humans and rodents. The ability to balance immediate delayed gratification is essential for fine-tuning decision-making processes achieve optimal rewards. Although has been extensively studied using human neuropsychological assessments, brain imaging techniques, preclinical research, the impact of chronic pain on these remains poorly understood. In this study, we successfully trained male rats perform a custom task (DGt) evaluate time-reward associations. required choose between two levers associated with distinct schedules reward delivery magnitude. Behavioral performance was assessed within subjects following induction inflammatory complete Freund's adjuvant (CFA) model. Our findings revealed that CFA-treated developed mechanical allodynia demonstrated strong preference small contrast, saline-treated control exhibited more balanced choice profile, indicative intact self-control. Collectively, results offer novel insights into how disrupts preferences impairs self-control mechanisms.

Language: Английский

Inflammatory pain modifies reward preferences from larger delayed to smaller immediate rewards in male rats DOI Creative Commons
Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo

et al.

Neuroscience Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138183 - 138183

Published: March 1, 2025

Self-control underlies goal-directed behavior in both humans and rodents. The ability to balance immediate delayed gratification is essential for fine-tuning decision-making processes achieve optimal rewards. Although has been extensively studied using human neuropsychological assessments, brain imaging techniques, preclinical research, the impact of chronic pain on these remains poorly understood. In this study, we successfully trained male rats perform a custom task (DGt) evaluate time-reward associations. required choose between two levers associated with distinct schedules reward delivery magnitude. Behavioral performance was assessed within subjects following induction inflammatory complete Freund's adjuvant (CFA) model. Our findings revealed that CFA-treated developed mechanical allodynia demonstrated strong preference small contrast, saline-treated control exhibited more balanced choice profile, indicative intact self-control. Collectively, results offer novel insights into how disrupts preferences impairs self-control mechanisms.

Language: Английский

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