Impact of New COVID-19 Variant on Stroke, Thrombosis and Neurological Impairment DOI Creative Commons
Richa Das,

Shreni Agrawal,

Nancy Singh

et al.

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has devastated the world with disease 2019 (COVID-19). SARS-CoV-2 is an RNA virus that a high mutation rate producing new variant serious threats. Recently emerged delta (B.1.617.2) (India), and omicron (B.1.1.529) (South Africa) mutant makes more attention than others previously known. These variants exhibit many neurological complications. The of COVID-19 are also involved in gut microbiota dysbiosis, thus enhancing inflammation process which then causes stroke, diabetes thrombosis. Administering vaccines crucial due to continual introduction concern. Therefore, modified have been thought as potential vaccines.

Language: Английский

A review of SARS-CoV-2 variants and vaccines: Viral properties, mutations, vaccine efficacy, and safety DOI Creative Commons
Md. Aminul Islam

Infectious Medicine, Journal Year: 2023, Volume and Issue: 2(4), P. 247 - 261

Published: Sept. 13, 2023

The severe acute respiratory syndrome coronavirus disease 2 instigated by of 2019 (COVID-19) has delivered an unfathomable obstruction that touched all sectors worldwide. Despite new vaccine technologies and mass administration booster doses, the virus persists, unknown ending pandemic for variants sub-variants. Moreover, whether leaning on home medications or using plant extracts is sufficient often to combat generated tremendous interest in scientific fraternity. Different databases including PubMed, Scopus, Web Science, Google Scholar used find published articles linked with related topics. Currently, COVID-19 third fourth shots vaccines are progressively administered worldwide, where some countries trail others a significant margin. Many proteins viral activity have changed, possibly boosting infectivity making antibodies ineffective. This study will reminisce genome, associated pathways protein functions, variants, their mutations. current, comprehensive review also provide information developed several biotech companies efficacy costs boosters level. As no working protect fully against proactive research needs be conducted based sub-lineage,

Language: Английский

Citations

25
Immune evasion of Omicron variants JN.1, KP.2, and KP.3 to the polyclonal and monoclonal antibodies from COVID-19 convalescents and vaccine recipients DOI
Qian Wu,

Hairuo Wu,

Yabin Hu

et al.

Antiviral Research, Journal Year: 2025, Volume and Issue: unknown, P. 106092 - 106092

Published: Jan. 1, 2025

Language: Английский

Citations

0
Recent SARS-CoV-2 evolution trajectories indicate the emergence of Omicron’s several subvariants and the current rise of KP.3.1.1 and XEC DOI
Chiranjib Chakraborty, Manojit Bhattacharya, Ali S. Abdelhameed

et al.

Virology, Journal Year: 2025, Volume and Issue: unknown, P. 110508 - 110508

Published: March 1, 2025

Language: Английский

Citations

0
Changes in children respiratory infections pre and post COVID-19 pandemic DOI Creative Commons
Yuanyuan Yue, Dan Wu, Qian Zeng

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 7, 2025

Non-pharmaceutical interventions (NPIs) implemented during the COVID-19 pandemic had a significant impact on prevalence of various acute respiratory infections (ARIs) pathogens. We collected 337,310 real-time PCR results for 13 pathogens from clinical samples between January 2018 and 2024 to assess changes ARIs among children before after pandemic. A variety pathogens, including Influenza (Flu A), B B), Adenovirus (ADV), Rhinovirus (RhV), Respiratory Syncytial Virus (RSV), as well co-infecting bacterial such Klebsiella pneumoniae (KPN), Pseudomonas aeruginosa (PAE), Streptococcus (SP), Haemophilus influenzae (HI), Listeria monocytogenes (LP), reached peak positive rate at age 3. The susceptible Mycoplasma (MP) was 3 7 years old. Compared pre-COVID period, rates Flu A, MP, ADV, SP, HI, Staphylococcus aureus (SA) KPN decreased And PAE increased. period pandemic, RSV, RhV, KPN, SA were increased Conversely, B, Parainfluenza virus (PIV) decreased. implementation NPIs interrupted circulation However, release reduced baseline population immunity, may contribute resurgence children.

Language: Английский

Citations

0
Antibody evasion associated with the RBD significant mutations in several emerging SARS-CoV-2 variants and its subvariants DOI
Manojit Bhattacharya, Srijan Chatterjee, Sang‐Soo Lee

et al.

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 71, P. 101008 - 101008

Published: Sept. 22, 2023

Language: Английский

Citations

10
Effectiveness of COVID-19 Vaccination against Severe Symptoms and Death Among Geriatric Inpatients: A Retrospective Cohort Study in Macao DOI Creative Commons

Xiao Zhan Zhang,

Phyllis Hio Hong Wong,

Kai Seng Lai

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(8), P. 933 - 933

Published: Aug. 21, 2024

Monitoring the effectiveness of COVID-19 vaccination is critical for understanding if vaccinated population, especially elderly, adequately protected from emergence new SARS-CoV-2 variants. This study aimed to investigate effects on severity symptoms and mortality in hospitalized geriatric patients during Omicron BF.7 surge Macao. Data electronic health records registry inpatients aged 60 years or above admitted Kiang Wu Hospital 12 December 2022 March 2023 were retrospectively analyzed. The involved 848 people, including 426 422 unvaccinated individuals. mean CXR scores (8.95 ± 9.49 vs. 11.41 10.81,

Language: Английский

Citations

1
Polarization- and CGR-based binary representations as identifiers of the nucleotide sequences in bioinformatics DOI Creative Commons
Dmitry A. Zimnyakov, М. В. Алонова,

Anatolij Skripal

et al.

Izvestiya VUZ Applied Nonlinear Dynamics, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Purpose of this work is the comparative analysis two approaches to synthesis two-dimensional binary identifiers nucleotide sequences obtained using DNA sequencing biological objects. Methods. One based on modeling polarization-dependent diffraction a coherent readout beam phase-modulating structure (phase screen) associated with symbolic sequence as result sequencing. Another approach uses representation chaos game (CGR). To obtain finite-element CGR mapping, it fragmented into given number cells, ensuring acceptable sensitivity synthesized identifier structural changes in displayed sequence. Results. The was carried out fragments symbol corresponding various strains (Wuhan, Delta, Omicron) SarSCoV2 virus. In course analysis, correlation coefficients between were and compared each other. Conclusion. It has been established that polarization encoding technique are characterized by significantly higher analyzed smaller sizes identifiers.

Language: Английский

Citations

0
Characteristics of virus and antibody response in an immunocompromised patient with persistent SARS-CoV-2 infection DOI

Shunsuke Yazawa,

Kei Fukuyama,

Rie Kawakami

et al.

Journal of Infection and Chemotherapy, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

Citations

0
Detection of SARS-CoV-2 in wastewater as an earlier predictor of COVID-19 epidemic peaks in Venezuela DOI Creative Commons

Marjorie Bastardo-Méndez,

Héctor R. Rangel, Flor H. Pujol

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 8, 2024

Wastewater-based epidemiological surveillance has proven to be a useful and cost-effective tool for detecting COVID-19 outbreaks. Here, our objective was evaluate its potential as an early warning system in Venezuela by SARS-CoV-2 RNA wastewater correlation with reported cases of COVID-19. Viral concentrated from collected at various sites Caracas (northern Venezuela), September 2021 July 2023, using the polyethylene glycol (PEG) precipitation method. quantification performed RT-qPCR targeting N1 ORF1ab genes. A significant association (p < 0.05) found between viral load up six days after sampling. During whole study, two populated areas city were persistent hotspots infection. The L452R mutation, suggestive presence Delta variant, identified only sample where complete genomic sequence could obtained. Significant differences physicochemical conditions samples positive negative virus found. Our results support proof concept that can serve outbreaks, complementing public health those regions is currently underreported.

Language: Английский

Citations

0
Human monoclonal antibody F61 nasal spray effectively protected high-risk populations from SARS-CoV-2 variants during the COVID-19 pandemic from late 2022 to early 2023 in China DOI Creative Commons
Ying Liu, Jiayou Zhang, Wen Liu

et al.

Emerging Microbes & Infections, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 16, 2023

Following the national dynamic zero-COVID strategy adjustment, utilization of broad-spectrum nasal neutralizing antibodies may offer alternative approach to controlling outbreak Omicron variants between late 2022 and early 2023 in China. This study involved an investigator-initiated trial (IIT) assess pharmacokinetic, safety efficacy F61 spray. A total 2,008 participants were randomly assigned receive spray (24 mg/0.8 mL/dose) or normal saline (0.8 1,336 completed follow-up IIT. Minimal absorption antibody into bloodstream was detected individuals receiving for seven consecutive days. No treatment-emergent adverse reactions grade 3 severity higher reported. In one-dose cohort, 7-day cumulative SARS-CoV-2 infection rate 79.0% group 82.6% placebo group, whereas, multiple-dose (once daily 7 days) rates 6.55% 23.83% group. The laboratory-confirmed 3.78% (-3.74%–10.75%) cohort 72.19% (57.33%–81.87%) cohort. real-world study, 60,225 volunteers four different regions administered based on subject's wishes, over 90% observed against variants. spray, with its favorable profile, could be a promising prophylactic monoclonal VOCs.

Language: Английский

Citations

1