Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11451 - 11467
Published: Dec. 1, 2024
Septic cardiomyopathy (SCM) is a significant global public health concern characterized by substantial morbidity and mortality, which has not been improved for decades due to lack of early diagnosis effective therapies. This study aimed identify hub biomarkers in SCM explore their potential mechanisms.
Language: Английский
Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103321 - 103321
Published: Aug. 19, 2024
Cell death constitutes a critical component of the pathophysiology cardiovascular diseases. A growing array non-apoptotic forms regulated cell (RCD)-such as necroptosis, ferroptosis, pyroptosis, and cuproptosis-has been identified is intimately linked to various conditions. These RCD are governed by genetically programmed mechanisms within cell, with epigenetic modifications being common crucial regulatory method. Such include DNA methylation, RNA histone acetylation, non-coding RNAs. This review recaps roles modifications, RNAs in diseases, well which regulate key proteins involved death. Furthermore, we systematically catalog existing pharmacological agents targeting novel their action article aims underscore pivotal role precisely regulating specific pathways thus offering potential new therapeutic avenues that may prove more effective safer than traditional treatments.
Language: Английский
Citations
7
Intensive Care Medicine Experimental, Journal Year: 2025, Volume and Issue: 13(1)
Published: Feb. 18, 2025
Abstract Sepsis is a life-threatening multi-organ dysfunction syndrome caused by dysregulated host response to infection, posing significant global healthcare challenge. Sepsis-induced myocardial (SIMD) common complication of sepsis, significantly increasing mortality due its high energy demands and low compensatory reserves. The substantial mitochondrial damage rather than cell apoptosis in SIMD suggests disrupted cardiac metabolism as crucial pathophysiological mechanism. Therefore, we systematically reviewed the mechanisms underlying SIMD, including alterations substrates, excitation–contraction coupling processes, dysfunction, autophagy biogenesis, summarizing potential therapeutic targets within them.
Language: Английский
Citations
0
Artificial Organs, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Neurological impairments seriously affect the quality of life in patients with venoarterial extracorporeal membrane oxygenation (VA-ECMO). However, underlying mechanisms have been restricted to a satisfactory animal model determined support and recovery time. This study aimed establish rodent VA-ECMO different durations, assessing feasibility long-term surviving Thirty-six Sprague-Dawley rats were divided into five groups: sham group (n = 10), ECMO-2 h 5), ECMO-3 ECMO-4 11) ECMO-6 5). The was further assigned time postoperative day 7 6) perform Morris water maze. established through right external jugular vein-right atrium for venous drainage tail artery arterial infusion. branch left femoral cannulated blood pressure monitoring gas analyses. Thereafter, brains fixed histopathological assessment. All processes successfully achieved, one rat died 2 after ECMO. physiologic variables all stable. Histologic deficits (pathological score, neurons, loss dendritic spines) detectable more than 3 support, functional observed 4 exposure, which persisted days. We reproducible cerebral histologic depending on duration. neurocognitive performance impaired 4-h exposure 3-day frame.
Language: Английский
Citations
0
Gene, Journal Year: 2024, Volume and Issue: unknown, P. 148944 - 148944
Published: Sept. 1, 2024
Language: Английский
Citations
1
International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(15), P. 6222 - 6240
Published: Nov. 11, 2024
PGAM5 and VDAC1 have both been reported to regulate mitophagy. However, the mechanisms by which they sepsis-induced inflammatory microvascular injury remain unverified. In previous studies, we established role of this regulatory axis in various phenotypic processes, including mitophagy, mitochondrial biogenesis, unfolded protein response, dynamics, while further confirming interactive proteins within axis. validation elucidation these phenotypes primarily focused on ischemic heart diseases such as myocardial failure. Sepsis-related is currently recognized a significant cardiac impairment, although there are cardioprotective nutritional agents available for supportive therapy, fundamental research validating upstream targets still lacking. Based our research, explored mitophagy dysfunction mediated its coronary injury. We also confirmed material basis metabolic pathway regulation targeting PGAM5- mechanism with relevant drugs. Our findings suggest that PGAM5-mediated may be crucial factor leading injury, interacting VDAC1-mediated membrane dysfunction. Animal experiments revealed cardiac-specific knockout could reverse LPS-induced damage, restoring ejection function functionality. vitro studies PGAM5-VDAC1 interaction can normalize normal morphology structure mitochondria maintaining energy metabolism levels respiratory chain function. Further pharmacological indicated active ingredients traditional Chinese medicine-Puerarin (TCM, GAS6 Receptor Agonist) target inhibit necrotic apoptosis cardiomyocytes, potentially reversing pathway-related TCM emerge prospective therapeutic agent
Language: Английский
Citations
1
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11451 - 11467
Published: Dec. 1, 2024
Septic cardiomyopathy (SCM) is a significant global public health concern characterized by substantial morbidity and mortality, which has not been improved for decades due to lack of early diagnosis effective therapies. This study aimed identify hub biomarkers in SCM explore their potential mechanisms.
Language: Английский
Citations
0