Obesity and acylcarnitine derivates interplay with coronary artery disease DOI Creative Commons
Tomasz Urbanowicz,

Paweł Gutaj,

Szymon Plewa

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 5, 2025

Coronary artery disease (CAD) is common in patients burdened with metabolic syndrome. Increased risk of cardiovascular associated abnormal levels acylated derivates carnitine. The present study aimed to evaluate the possible association between carnitine derivatives and coronary disease, including obese individuals. Twenty consecutive presenting dyspnea on exertion were enrolled prospective analysis for metabolomic profiling. They divided into two groups regarding CAD presence. Six (60%) men four (40%) women comprised group assigned as Group 1, while 6 4 normal arteries angiograms 2. Compared non-CAD group, was characterized by lower sum long-chain ACs (p = 0.024), short-chain 0.022), saturated fatty acids (SFA) 0.030) monounsaturated (MUFA) 0.022). Further subanalysis concerning patients' body mass index showed significant differences plasma 0.050) SFA but not 0.060), medium-ACs 0.758), long-chain-ACs 0.141), or MUFA 0.151). Our revealed acylcarnitine CAD.

Language: Английский

Association between air pollution and cardiovascular disease risk in middle-aged and elderly individuals with diabetes: inflammatory lipid ratio accelerate this progression DOI Creative Commons

Chun-Yu Yan,

Guang Chen,

Yingyu Jing

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 21, 2025

Long-term exposure to air pollution significantly increases the risk of cardiovascular disease (CVD); however, association and underlying mechanisms in individuals with diabetes remain unconfirmed. We used data from China Health Retirement Longitudinal Study (CHARLS) follow 5,430 adults over a four-year period. Baseline CVD status were determined, high-resolution assess PM1, PM2.5, PM10, O3. The inflammatory lipid ratio (ILR) was calculated reflect metabolic states. A generalized linear model (GLM) employed analyze effects ILR on diabetes-related risk. prevalence 8.5% healthy population 13.8% diabetic population. Air associated an increased among individuals. For each interquartile range (IQR) increase concentrations pollutants O3, group rose by 21%, 19%, 28%, respectively. Higher values positively incidence (OR = 1.019, 95% CI: 1.001-1.037, P < 0.05), nonlinear relationship observed between levels (PNonlinear 0.0381), indicating that higher exacerbate impact Among middle-aged older diabetes, is CVD, intensifies this process. Therefore, implementing effective public health interventions reduce populations essential.

Language: Английский

Citations

3
Emodin Induces Oxidative Stress and Ferroptosis in Hepatocellular Carcinoma Cells via Inactivating miR- 4465/NFE2L3/HMGCR/GPX4 Signaling Axis DOI

Zhiran Ding,

Menghua Zheng,

Yu Li

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Abstract Ferroptosis is a form of programmed cell death characterized by iron-dependent lipid peroxidation. Targeting ferroptosis considered novel strategy for cancer treatment. The benefits using natural products to treat tumors have drawn more attention. Emodin, anthraquinone derivative, has been shown exert anti-tumor effects promoting the generation and accumulation reactive oxygen species (ROS), inducing apoptosis, autophagy, cycle arrest. molecular processes behind Emodin-mediated in hepatocellular carcinoma (HCC) cells were examined our work. Emodin caused suppressed growth HCC vitro. could increase ROS peroxidation, meanwhile decreasing glutathione (GSH), mitochondrial membrane potential, peroxidase 4 (GPX4), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) expression, these be reversed Ferostatin-1 (Fer-1, an inhibitor ferroptosis) NFE2-like bZIP transcription factor 3 (NFE2L3). Mechanistically, enhances expression miR-4465, thereby suppressing NFE2L3 expression. interaction between HMGCR promoter diminished, which subsequently downregulates GPX4 via mevalonate pathway, leading ferroptosis. Overexpression alleviate Emodin-induced cells. Moreover, knockout markedly reduced Nfe2l3−/−mouse model. also inhibited tumor development xenograft mice In conclusion, results suggested that induces inactivating NFE2L3/HMGCR/GPX4 pathway may promising candidate anticancer drugs offers new strategies therapy.

Language: Английский

Citations

0
Predictors of in-hospital mortality in patients with acute coronary syndrome DOI
Cihan Aydın, Mesut Engin, Aykut Demirkıran

et al.

Coronary Artery Disease, Journal Year: 2025, Volume and Issue: 36(4), P. 350 - 350

Published: April 29, 2025

Language: Английский

Citations

0
Obesity and acylcarnitine derivates interplay with coronary artery disease DOI Creative Commons
Tomasz Urbanowicz,

Paweł Gutaj,

Szymon Plewa

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 5, 2025

Coronary artery disease (CAD) is common in patients burdened with metabolic syndrome. Increased risk of cardiovascular associated abnormal levels acylated derivates carnitine. The present study aimed to evaluate the possible association between carnitine derivatives and coronary disease, including obese individuals. Twenty consecutive presenting dyspnea on exertion were enrolled prospective analysis for metabolomic profiling. They divided into two groups regarding CAD presence. Six (60%) men four (40%) women comprised group assigned as Group 1, while 6 4 normal arteries angiograms 2. Compared non-CAD group, was characterized by lower sum long-chain ACs (p = 0.024), short-chain 0.022), saturated fatty acids (SFA) 0.030) monounsaturated (MUFA) 0.022). Further subanalysis concerning patients' body mass index showed significant differences plasma 0.050) SFA but not 0.060), medium-ACs 0.758), long-chain-ACs 0.141), or MUFA 0.151). Our revealed acylcarnitine CAD.

Language: Английский

Citations

0