Oxidative DNA Damage and Arterial Hypertension in Light of Current ESC Guidelines DOI Open Access

Radka Hazuková,

Z Zadák,

M Pleskot

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12557 - 12557

Published: Nov. 22, 2024

A new insight into oxidative stress is based on deoxyribonucleic acid (DNA) damage. DNA the pivotal biopolymer for life and health. Arterial hypertension (HT) a globally common disease major risk factor numerous cardiovascular (CV) conditions non-cardiac complications, making it significant health socio-economic problem. The aetiology of HT multifactorial. Oxidative main driver. damage (oxidised guanosine (8OHdG), strand breaks (SSBs, DSBs)) seems to be crucial initiating causal molecular mechanism leading HT, acting through resulting consequences (inflammation, fibrosis, vascular remodelling, stiffness, thickness, endothelial dysfunction). In light current European Society Cardiology (ESC) guidelines with defined gaps in evidence, this manuscript, first time, (1) summarizes evidence other CV factors, (2) incorporates them context known mechanisms genesis, (3) proposes existing concept genesis innovatively supplemented damage, (4) mentions such as promising targets treatment (DNA response (DDR) pathways).

Language: Английский

Oxidative Stress Responses in Obese Individuals Undergoing Bariatric Surgery: Impact on Carcinogenesis DOI Creative Commons
Daniel Araki Ribeiro, Glenda Nicioli da Silva, Ingra Taís Malacarne

et al.

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(3), P. 352 - 366

Published: July 4, 2024

Obesity is a big public health problem that claims several thousand lives every year. Bariatric surgery has arisen as suitable procedure for treating obesity, particularly morbid obesity. Oxidative stress, genotoxicity, apoptosis, and inflammatory responses are recognized the most important occurrences in carcinogenesis, they actively contribute to multistep process. This study aimed briefly review connection between oxidative inflammation obese patients undergoing bariatric surgery, focusing on its impact carcinogenesis. Regarding may inhibit synthesis of reactive oxygen species. Moreover, significant reduction status after weight loss was not observed. prevents apoptosis tissues, but maintenance low body long periods mandatory mitigating DNA damage. In conclusion, association cancer risk still premature. However, further studies yet needed elucidate real reduced cancer.

Language: Английский

Citations

1
Oxidative DNA Damage and Arterial Hypertension in Light of Current ESC Guidelines DOI Open Access

Radka Hazuková,

Z Zadák,

M Pleskot

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12557 - 12557

Published: Nov. 22, 2024

A new insight into oxidative stress is based on deoxyribonucleic acid (DNA) damage. DNA the pivotal biopolymer for life and health. Arterial hypertension (HT) a globally common disease major risk factor numerous cardiovascular (CV) conditions non-cardiac complications, making it significant health socio-economic problem. The aetiology of HT multifactorial. Oxidative main driver. damage (oxidised guanosine (8OHdG), strand breaks (SSBs, DSBs)) seems to be crucial initiating causal molecular mechanism leading HT, acting through resulting consequences (inflammation, fibrosis, vascular remodelling, stiffness, thickness, endothelial dysfunction). In light current European Society Cardiology (ESC) guidelines with defined gaps in evidence, this manuscript, first time, (1) summarizes evidence other CV factors, (2) incorporates them context known mechanisms genesis, (3) proposes existing concept genesis innovatively supplemented damage, (4) mentions such as promising targets treatment (DNA response (DDR) pathways).

Language: Английский

Citations

0