Cdh11: Roles in different diseases and potential value in disease diagnosis and treatment

Biochemistry and Biophysics Reports, Journal Year: 2023, Volume and Issue: 36, P. 101576 - 101576

Published: Nov. 15, 2023

Cadherin is a homophilic, Ca2+-dependent cell adhesion glycoprotein that mediates cell-cell adhesion. Among them, Cadherin-11 (CDH11), as classical cadherin, participates in and influences many crucial aspects of human growth development. Furthermore, The involvement CDH11 has been identified an increasing number diseases, primarily including various tumorous fibrotic autoimmune neurodevelopmental disorders, more. In acts not only tumor suppressor but can also promote migration invasion certain tumors through mechanisms. Likewise, non-tumorous remains pivotal factor disease progression. this context, we summarize the specific functionalities mechanisms aiming to gain more comprehensive understanding potential value diagnosis treatment. This endeavor seeks provide effective diagnostic therapeutic strategies for clinical management across diverse diseases.

Language: Английский

Identifying stage-associated hub genes in bladder cancer via weighted gene co-expression network and robust rank aggregation analyses

Medicine, Journal Year: 2022, Volume and Issue: 101(51), P. e32318 - e32318

Published: Dec. 23, 2022

Bladder cancer (BC) is among the most frequent cancers globally. Although substantial efforts have been put to understand its pathogenesis, underlying molecular mechanisms not fully elucidated.

Language: Английский