B Cell Dynamics in HIV Pathogenesis: Insights and Implications

Annals of Immunology & Immunotherapy, Journal Year: 2024, Volume and Issue: 6(1)

Published: Jan. 1, 2024

Human Immunodeficiency Virus (HIV) infection remains a global health challenge, with intricate interactions between the virus and immune system, particularly B cells, significantly influencing disease progression. This review aims to provide comprehensive examination of cell dynamics during HIV pathogenesis, offering insights into implications for therapeutic interventions, vaccine design, broader understanding HIV-associated dysfunction. The begins by outlining epidemiology emphasizing critical impact on specific focus cells. It explores alterations in subpopulations, including memory depletion dysregulation, highlighting their function infection. consolidates current knowledge providing foundation advancing our host-virus interactions. gained from this exploration hold significant development targeted strategies informed approaches prevention treatment.

Language: Английский

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Anemia and Erythropoietin in HIV: A Multifaceted Review

Haematology International Journal, Journal Year: 2024, Volume and Issue: 8(1)

Published: Jan. 1, 2024

Anemia stands as a significant and multifaceted complication in the landscape of HIV, introducing dynamic interplay viral, immune, hematopoietic factors. This comprehensive review navigates intricate relationship between anemia erythropoietin context elucidating pathogenesis, clinical implications, evolving treatment paradigms. With an emphasis on co-infection dynamics, pivotal role erythropoietin, this explores nature providing holistic understanding crucial for effective management. The implications extend beyond hematological realm, impacting overall health underscoring need tailored strategies. Moreover, delves into interventions, including erythropoiesis-stimulating agents novel therapies, offering insights future management complex HIV. Through critical examination current knowledge identification research gaps, serves resource clinicians, researchers, healthcare providers navigating terrain HIV infection.

Language: Английский

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Prevalence and Determinants of Early Sexual Debut among Teenage Students: A Study in Kiryandongo District, Uganda

IAA Journal of Applied Sciences, Journal Year: 2024, Volume and Issue: 11(2), P. 65 - 75

Published: April 12, 2024

Early sexual debut among teenagers is a global concern, particularly prevalent in developing countries. This study aimed to investigate the prevalence and factors associated with early teenage students at Kibanda Secondary School Kiryandongo district, Uganda. A cross-sectional was conducted, involving 150 respondents. Data were collected using self-administered questionnaires analyzed IBM SPSS 27.0. The of found be 20.0%, predictors including age, sex, caregiver's education level income, parental history substance abuse, personal first partner. Female respondents 2.17 times more likely have an compared males, abuse 4.03 initiate sex early. Low caregiver income also debut. These findings underscore need for targeted interventions programs mitigate risks initiation teenagers. Keywords: debut, Sexual intercourse, Teenage, Students

Language: Английский

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Prevalence and Factors Associated with Pulmonary Tuberculosis Infection among HIV/AIDS Patients Attending an ART Clinic: A Study at Fort Portal Regional Referral Hospital

IDOSR JOURNAL OF BIOCHEMISTRY BIOTECHNOLOGY AND ALLIED FIELDS, Journal Year: 2024, Volume and Issue: 9(1), P. 116 - 125

Published: April 11, 2024

Among the over 33 million individuals living with HIV/AIDS, one-third also contracted tuberculosis, making it a significant co-infection. Tuberculosis emerged as primary cause of illness and death within HIV/AIDS community, responsible for approximately 30% all fatalities among those affected. While curable when accurately diagnosed promptly treated, addressing tuberculosis in patients required special attention due to intricacies involved diagnosing treating both conditions concurrently. Employing quantitative cross-sectional design, study aimed ascertain PTB prevalence its socio-demographic behavioral determinants attending ART clinic. Eighty-seven participants were selected via simple random sampling, questionnaires serving data collection tool. The findings revealed association between age 45 years occurrence pulmonary TB, an odds ratio 0.71 (0.45–3.77) p-value 0.035. Additionally, male gender exhibited notable HIV patients, 0.48 (0.15-8.14) 0.001. Furthermore, indicated correlation 0.35 (0.001-3.79) 0.024. study's conclusion highlighted that 18.4% HIV-positive had experienced tuberculosis. Recommendations included promoting good adherence TB prophylaxis bolster immunity against TB. Encouraging steer clear behaviors heighten risk, such smoking excessive alcohol consumption, was advised. government urged enhance support supplies aiming prevent disease progression through tertiary interventions. Keywords: patients; Tuberculosis; Smoking drinking,

Language: Английский

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B Cell Dysfunction in HIV: Implications for Novel Therapeutic Strategies

Haematology International Journal, Journal Year: 2024, Volume and Issue: 8(1)

Published: Jan. 1, 2024

Human Immunodeficiency Virus (HIV) infection remains a global health challenge, characterized by progressive immune dysregulation leading to acquired immunodeficiency syndrome (AIDS). Among the myriad alterations observed in HIV, dysfunction of B lymphocytes plays significant role disease progression. This review article critically examines multifaceted cells during HIV infection, encompassing altered phenotypes, impaired functions, and disrupted interactions within microenvironment. The involves diverse mechanisms, including direct viral effects, chronic activation, cytokine milieu. Such manifests as compromised antibody production, perturbed cell subsets, memory responses, aberrant secretion, contributing diminished humoral immunity dysregulation. Understanding these intricacies is pivotal for elucidating pathogenesis developing targeted therapeutic strategies. paper delineates implications HIV-associated therapies. It highlights promising approaches, immunotherapies targeting function modulation, potential modifications or adjunctive therapies alongside standard antiretroviral therapy (ART) address abnormalities, innovative strategies aimed at restoring HIV-infected individuals. elucidation offers unique avenue interventions. Targeting not only aims restore but also holds promise ameliorating overall function, potentially augmenting current treatment paradigms.

Language: Английский

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