Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Factors leading to severe COVID-19 remain partially known. New biomarkers predicting severity that are also causally involved in disease pathogenesis could improve patient management and contribute the development of innovative therapies. Autophagy, a cytosolic structure degradation pathway is maintenance cellular homeostasis, intracellular pathogens generation energy for immune responses. Acyl-CoA binding protein (ACBP) key regulator autophagy context diabetes, obesity anorexia. The objective our work was assess whether circulating ACBP levels associated with severity, using proteomics data from plasma 903 patients. Somalogic proteomic analysis used detect 5000 proteins samples collected between March 2020 August 2021 hospitalized participants province Quebec, Canada. Plasma patients during their admission acute phase 295 controls were assessed 1198 interpretable profiles. Levels anti-SARS-CoV-2 IgG measured by ELISA cell-binding assay. median age 59 years, 46% female, 65% had comorbidities. correlated association inflammation antibody levels, independently sex or presence Samples second wave Quebec higher than first wave. negatively T NK cell responses interferon-γ, tumor necrosis factor-α interleukin-21, age, sex, severity. Circulating can be considered biomarker linked inflammation. contribution extracellular immunometabolic viral infection should further studied.

Language: Английский

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Chronic Obstructive Pulmonary Disease and COVID-19: The Impact of Hematological Biomarkers on Disease Severity and Outcomes

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2765 - 2765

Published: April 17, 2025

Background/Objectives: Chronic obstructive pulmonary disease (COPD) patients are at heightened risk of severe COVID-19 due to underlying respiratory impairment, systemic inflammation, and immune dysregulation. This review explores the hematological changes that occur in COPD with their implications for progression, prognosis, clinical management. Methods: We conducted a comprehensive analysis recent peer-reviewed studies from medical databases including Clarivate Analytics, PubMed, Google Scholar. Results: Hematological alterations, such as lymphopenia, elevated neutrophil-to-lymphocyte ratio (NLR), increased D-dimer fibrinogen levels, inflammatory anemia, erythrocyte dysfunction, commonly observed COVID-19. These linked suppression, hyperinflammation, oxidative stress, thromboembolic complications. Conclusions: biomarkers valuable tools early assessments guiding treatment strategies this high-risk population. The regular monitoring D-dimer, fibrinogen, NLR is advisable. Prophylactic anticoagulation immunomodulatory therapies, corticosteroids IL-6 IL-1 inhibitors, may improve outcomes. Further needed validate personalized approaches explore antioxidant-based interventions.

Language: Английский

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Evaluation of clinically relevant serum proteins as biomarkers for monitoring COVID-19 severity, and end-organ damage among hospitalized unvaccinated patients

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 20, 2024

Abstract Background The extensive variability and conflicting information in Coronavirus Disease 2019 (COVID-19) patient data have made it difficult for the medical community to gain a comprehensive understanding develop clear, reliable guidelines managing COVID-19 cases. As world uncovers diverse side effects of pandemic, pursuit knowledge about has become crucial. present study aimed evaluate some clinically relevant serum proteins, providing analysis obtained results employ them diagnosis, prognosis, disease monitoring among patients. Methods Samples were collected from 262 unvaccinated hospitalized Measurement certain namely C-reactive protein (CRP), ferritin, D-dimer, procalcitonin, interleukin-6 (IL-6), creatinine (SCr), alanine transaminase (ALT), aspartate (AST) was done using standard methods. Statistical performed on correlated severity prognosis. Results calculated Mortality rate found be 30% with higher percentage observed females. showed elevation CRP, procalcitonin most patients, also patients had elevated SCr, ALT, AST levels indicating end-organ damage. statistical displayed strong correlation between CRP D-dimer ferritin procalcitonin. No significant difference male female patients’ tested proteins. A increased mortality observed. Conclusion measured proteins impacted by SARS-CoV-2 infection. Serum are good predicting tools damage acute kidney impairment COVID-19. Procalcitonin is indicator

Language: Английский

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Efficacy of interleukin-6 inhibitors as a tool for preventive anti-inflammatory therapy for COVID-19

Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice, Journal Year: 2024, Volume and Issue: 1, P. 4 - 16

Published: April 19, 2024

The novel coronavirus infection (COVID-19) is characterized by damage, along with the lungs, to many other vital organs and systems. prevalence severity of resulting lesions are determined ability SARS-CoV-2 virus cause excessive activation immune response, accompanied changes in both cellular humoral components. Among disorders, most significant hypersecretion cytokines, including interleukins (IL), particular IL-6 IL1β. Elevated levels one main predictors severe COVID-19 death. So, blocking effects this cytokine fundamental importance for improving clinical outcomes patients. Monoclonal antibodies against human interleukin-6 receptor or have been widely studied patients extremely COVID-19, a lesser extent mild moderate severity. Regardless severity, maximum effectiveness achieved when these drugs administered as early possible, which made it possible create such tool preventive anti-inflammatory therapy. Preventive prescription inhibitors may be useful not only hospitalized inpatients, but also outpatients. This review aimed assess use ambulatory varying degrees COVID-19.

Language: Английский

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A cross-sectional study on clinical characteristics and severity of children with COVID-19 admitted to a teaching institute in North India

Journal of Family Medicine and Primary Care, Journal Year: 2024, Volume and Issue: 13(7), P. 2653 - 2662

Published: June 26, 2024

SARS-CoV-2 infection presentation in children is usually milder than adults but can be severe and fatal as well. Data on the pediatric population regarding severity clinical are still limited, there a need to have better understanding of features, severity, laboratory parameters.

Language: Английский

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Pulmonary embolism in children with mycoplasma pneumonia: can it be predicted?

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Language: Английский

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