Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis DOI Creative Commons
Juan Chen,

S. I. Ch ng,

Pengchao Xu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Introduction The XuLing JianGu recipe (XLJGR) is an empirical traditional Chinese medicine formula used for the treatment of osteoporosis. This study aims to explore effects XLJGR on intestinal microbiota composition and endogenous metabolites in ovariectomized (OVX) rats. Methods An OVX rat model was established evaluate intervention XLJGR. measured indicators included bone density, serum metabolism markers, analysis types abundances microbiota, along with changes metabolites. Additionally, MC3T3-E1 cells were validate differential Results significantly reduced abundance Bacteroides, Butyricicoccus, other bacterial strains gut. KEGG metabolic pathway enrichment showed that led notable pathways such as peptidoglycan biosynthesis, carbapenem vancomycin resistance. Moreover, upregulated key metabolites, including gabapentin(GAB), camphoric acid(CAA), nonanedioic acid(AZA), thereby promoting proliferation osteogenic differentiation cells. Discussion highlights potential biomedical applications health by positively affecting characteristics. These findings suggest may serve a viable alternative osteoporosis, warranting further exploration its therapeutic mechanisms clinical applications.

Language: Английский

The impact of fermented dairy products and probiotics on bone health improvement DOI Creative Commons
H. Bashir, Muhammad Hasnain,

Aoun Abbas

et al.

Food Science of Animal Resources, Journal Year: 2025, Volume and Issue: 45(2), P. 449 - 467

Published: Feb. 12, 2025

The bone is an important body organ due to its role in locomotion, protection and mineral homeostasis. Bone health affected by various intrinsic extrinsic factors like genetics, diet, environment immune status of individual. Being a dynamic organ, bones are continuously being remodeled the remodeling mediated intricate balance formation resorption which, turn, regulated environmental, genetic, hormonal neural factors. Lack any these leads disorders such as osteoporosis. Fermented dairy products along with their probiotics content play significant process ensuring maintenance forming cells (osteoblasts) (osteoclasts). Proteins minerals constituents bone. Dairy products, especially fermented ones, because good source proteins required make maintain healthy In addition, provide which involved improvement enhancing bioavailability dietary constituents, production short chain fatty acids reducing inflammatory components. Hence, should be regular part our diet keep healthy.

Language: Английский

Citations

0
Gut Microbiota-Derived Butyrate Enhances Exercise-Induced Bone Mineral Density in Humans DOI Creative Commons

Xiangya Dou,

Pengyu Fu, Yuting Zhang

et al.

Mechanobiology in Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100124 - 100124

Published: March 1, 2025

Language: Английский

Citations

0
Cross-talks between osteoporosis and gut microbiome DOI
Shiva Shankar Jha, Naveen Jeyaraman,

Madhan Jeyaraman

et al.

World Journal of Orthopedics, Journal Year: 2025, Volume and Issue: 16(3)

Published: March 12, 2025

Language: Английский

Citations

0
Dietary Fiber Intake Improves Osteoporosis Caused by Chronic Lead Exposure by Restoring the Gut–Bone Axis DOI Open Access

Renjie Wang,

Jin Shen,

Chunqing Han

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1513 - 1513

Published: April 29, 2025

Background: Lead (Pb), a pervasive environmental toxicant with specific toxicity to bone, has been recognized as significant etiological factor in the pathogenesis of osteoporosis. While dietary fiber (DF) demonstrates anti-osteoporotic potential, its protective role against Pb-induced bone loss remains unexplored. Methods: This study analyzed association between fiber, blood lead, and osteoporosis based on NHANES database, validated it by constructing lead exposed mouse model. Micro CT was used evaluate microstructure, ELISA detect markers, q-PCR/Western blot measure intestinal tight junction protein, flow cytometry analyze Treg cells colon/bone tissue, GC-MS short chain fatty acids, 16S rRNA sequencing changes gut microbiota. The regulatory mechanism metabolism barrier mice systematically evaluated. Results: Based data analysis, found that can reduce risk populations. Animal experiments have shown intervention significantly increases density, improves microstructure metabolic indicators, repairs damage caused exposure, regulates immune balance mice. At same time, promotes generation acids proliferation beneficial Conclusions: These findings indicate DF mitigates through restoration, SCFA-mediated immunomodulation, microbiota-driven cell expansion along gut–bone axis.

Language: Английский

Citations

0
Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis DOI Creative Commons
Juan Chen,

S. I. Ch ng,

Pengchao Xu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Introduction The XuLing JianGu recipe (XLJGR) is an empirical traditional Chinese medicine formula used for the treatment of osteoporosis. This study aims to explore effects XLJGR on intestinal microbiota composition and endogenous metabolites in ovariectomized (OVX) rats. Methods An OVX rat model was established evaluate intervention XLJGR. measured indicators included bone density, serum metabolism markers, analysis types abundances microbiota, along with changes metabolites. Additionally, MC3T3-E1 cells were validate differential Results significantly reduced abundance Bacteroides, Butyricicoccus, other bacterial strains gut. KEGG metabolic pathway enrichment showed that led notable pathways such as peptidoglycan biosynthesis, carbapenem vancomycin resistance. Moreover, upregulated key metabolites, including gabapentin(GAB), camphoric acid(CAA), nonanedioic acid(AZA), thereby promoting proliferation osteogenic differentiation cells. Discussion highlights potential biomedical applications health by positively affecting characteristics. These findings suggest may serve a viable alternative osteoporosis, warranting further exploration its therapeutic mechanisms clinical applications.

Language: Английский

Citations

0