Gestational Hydronephrosis: A Retrospective Analysis of the Clinical Outcomes of Ureteral Stent Placement Versus Conservative Treatment DOI Creative Commons
Dursun Baba, Engin Yurtçu,

Burak Ayvacık

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 845 - 845

Published: May 4, 2025

Background and Objectives: Gestational hydronephrosis (GH) is a physiological condition commonly observed during pregnancy, resulting from hormonal effects mechanical compression of the ureters by enlarging uterus. Although often asymptomatic, GH can cause urinary stasis, recurrent infections, renal function impairment in symptomatic cases. The optimal management such cases remains controversial, especially regarding role ureteral stent placement. This study aimed to compare clinical outcomes—including function, inflammatory markers, obstetric parameters—in pregnant women with who underwent placement versus those managed conservatively. Materials Methods: We conducted retrospective cohort at Düzce University Hospital between 2020 2024, including 40 diagnosed GH. patients were divided into following two groups: received (n = 20) conservative treatment 20). Conservative included hydration therapy, acetaminophen-based analgesia, close monitoring. parameters assessed serum creatinine, estimated glomerular filtration rate (GFR), markers (C-reactive protein, erythrocyte sedimentation rate, white blood cell count), findings, outcomes, postpartum complications. Statistical significance was set p < 0.05. Results: age diagnosis significantly higher group (29.1 ± 3.2 weeks) than non-stent (27.1 3.5 weeks; 0.045), possibly reflecting increased later pregnancy. Renal (serum creatinine GFR), (CRP, ESR, WBC outcomes (birth weight, Apgar scores) showed no significant differences groups (p > 0.05). Interestingly, gestational diabetes mellitus (GDM) more prevalent (20% vs. 5%; 0.042), although found fasting glucose levels. Conclusions: Ureteral does not appear improve or outcomes. However, it may provide symptom relief select persistent severe discomfort. Given limitations data small sample size, further prospective studies larger cohorts quality-of-life assessments are warranted optimize strategies enhance patient-centered care.

Language: Английский

Potential applications and mechanisms of natural products in mucosal-related diseases DOI Creative Commons
Lin Wang,

Xie Ruishi,

Xu Caijiao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

The mucosal barrier serves as a crucial defense against external pathogens and allergens, being widely distributed across the respiratory, gastrointestinal, urogenital tracts, oral cavity. Its disruption can lead to various diseases, including inflammatory bowel disease, asthma, urinary tract infections, inflammation. Current mainstream treatments for mucosa-associated diseases primarily involve glucocorticoids immunosuppressants, but their long-term use may cause adverse effects. Therefore, development of safer more effective therapeutic strategies has become focus research. Natural products, with multi-target multi-system regulatory advantages, offer promising avenue treatment diseases. This review summarizes potential applications natural products in dysfunction through mechanisms such immune modulation, inflammation inhibition, tight junction protein restoration, gut microbiota regulation, aim providing insights exploration novel strategies.

Language: Английский

Citations

0
Gestational Hydronephrosis: A Retrospective Analysis of the Clinical Outcomes of Ureteral Stent Placement Versus Conservative Treatment DOI Creative Commons
Dursun Baba, Engin Yurtçu,

Burak Ayvacık

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 845 - 845

Published: May 4, 2025

Background and Objectives: Gestational hydronephrosis (GH) is a physiological condition commonly observed during pregnancy, resulting from hormonal effects mechanical compression of the ureters by enlarging uterus. Although often asymptomatic, GH can cause urinary stasis, recurrent infections, renal function impairment in symptomatic cases. The optimal management such cases remains controversial, especially regarding role ureteral stent placement. This study aimed to compare clinical outcomes—including function, inflammatory markers, obstetric parameters—in pregnant women with who underwent placement versus those managed conservatively. Materials Methods: We conducted retrospective cohort at Düzce University Hospital between 2020 2024, including 40 diagnosed GH. patients were divided into following two groups: received (n = 20) conservative treatment 20). Conservative included hydration therapy, acetaminophen-based analgesia, close monitoring. parameters assessed serum creatinine, estimated glomerular filtration rate (GFR), markers (C-reactive protein, erythrocyte sedimentation rate, white blood cell count), findings, outcomes, postpartum complications. Statistical significance was set p < 0.05. Results: age diagnosis significantly higher group (29.1 ± 3.2 weeks) than non-stent (27.1 3.5 weeks; 0.045), possibly reflecting increased later pregnancy. Renal (serum creatinine GFR), (CRP, ESR, WBC outcomes (birth weight, Apgar scores) showed no significant differences groups (p > 0.05). Interestingly, gestational diabetes mellitus (GDM) more prevalent (20% vs. 5%; 0.042), although found fasting glucose levels. Conclusions: Ureteral does not appear improve or outcomes. However, it may provide symptom relief select persistent severe discomfort. Given limitations data small sample size, further prospective studies larger cohorts quality-of-life assessments are warranted optimize strategies enhance patient-centered care.

Language: Английский

Citations

0