Spatial multi-omics: deciphering technological landscape of integration of multi-omics and its applications DOI Creative Commons

Xiaojie Liu,

Ting Peng,

Miaochun Xu

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Aug. 24, 2024

The emergence of spatial multi-omics has helped address the limitations single-cell sequencing, which often leads to loss context among cell populations. Integrated analysis genome, transcriptome, proteome, metabolome, and epigenome enhanced our understanding biology molecular basis human diseases. Moreover, this approach offers profound insights into interactions between intracellular intercellular mechanisms involved in development, physiology, pathogenesis In comprehensive review, we examine current advancements technologies, focusing on their evolution refinement over past decade, including improvements throughput resolution, modality integration, accuracy. We also discuss pivotal contributions revealing heterogeneity, constructing detailed atlases, deciphering crosstalk tumor immunology, advancing translational research cancer therapy through precise mapping.

Language: Английский

Spatial multi-omics: deciphering technological landscape of integration of multi-omics and its applications DOI Creative Commons

Xiaojie Liu,

Ting Peng,

Miaochun Xu

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Aug. 24, 2024

The emergence of spatial multi-omics has helped address the limitations single-cell sequencing, which often leads to loss context among cell populations. Integrated analysis genome, transcriptome, proteome, metabolome, and epigenome enhanced our understanding biology molecular basis human diseases. Moreover, this approach offers profound insights into interactions between intracellular intercellular mechanisms involved in development, physiology, pathogenesis In comprehensive review, we examine current advancements technologies, focusing on their evolution refinement over past decade, including improvements throughput resolution, modality integration, accuracy. We also discuss pivotal contributions revealing heterogeneity, constructing detailed atlases, deciphering crosstalk tumor immunology, advancing translational research cancer therapy through precise mapping.

Language: Английский

Citations

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