Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification

Advances in cancer research, Journal Year: 2020, Volume and Issue: unknown, P. 1 - 61

Published: Nov. 28, 2020

Language: Английский

---

A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH

New England Journal of Medicine, Journal Year: 2021, Volume and Issue: 385(17), P. 1547 - 1558

Published: Oct. 20, 2021

Management of nonalcoholic steatohepatitis (NASH) is an unmet clinical need. Lanifibranor a pan-PPAR (peroxisome proliferator–activated receptor) agonist that modulates key metabolic, inflammatory, and fibrogenic pathways in the pathogenesis NASH.

Language: Английский

---

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 174 - 174

Published: Jan. 26, 2021

Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory chronic liver diseases, including non-alcoholic disease (NAFLD). Chronic impairment lipid metabolism closely related to alterations oxidant/antioxidant balance, which affect metabolism-related organelles, leading cellular lipotoxicity, peroxidation, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Increased OxS also triggers hepatocytes pathways, inflammation fibrogenesis, contributing progression steatohepatitis (NASH). The antioxidant response, regulated by Nrf2/ARE pathway, key component this process counteracts oxidative stress-induced damage, restoration normal metabolism. Therefore, modulation response emerges as an interesting target prevent NAFLD development progression. This review highlights link between disturbed context NAFLD. In addition, emerging potential therapies based on effects their likely molecular targets are discussed.

Language: Английский

---

Hesperetin ameliorates hepatic oxidative stress and inflammationviathe PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD

Food & Function, Journal Year: 2021, Volume and Issue: 12(9), P. 3898 - 3918

Published: Jan. 1, 2021

Hesperetin as a major bioflavonoid in citrus fruits improves NAFLD by suppressing hepatic oxidative stress and inflammation.

Language: Английский

---

Association of Inflammatory Cytokines With Non-Alcoholic Fatty Liver Disease

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 6, 2022

Background Inflammatory cytokines have been considered to be significant factors contributing the development and progression of non-alcoholic fatty liver disease (NAFLD). However, role inflammatory in NAFLD remains inconclusive. Objective This study aimed evaluate association between NAFLD. Methods PubMed, Web Science, Cochrane Library, EMBASE databases were searched until 31 December 2021 identify eligible studies that reported cytokine with its subtypes. We pooled odds ratios (ORs) hazard risk (HRs) 95% confidence intervals (CIs) conducted heterogeneity tests. Sensitivity analysis for publication bias also carried out. Results The search identified 51 relevant investigated 19 different based on 36,074 patients 47,052 controls. results meta-analysis showed associations C-reactive protein (CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), intercellular adhesion molecule-1 (ICAM-1) (ORs 1.41, 1.08, 1.50, 1.15 2.17, respectively). In contrast, we observed non-significant interferon-γ (IFN-γ), insulin-like growth factor (IGF-II), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-7 (IL-7), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-12 (IL-12), monocyte chemoattractant protein-1(MCP-1), transforming factor-β (TGF-β) Our CRP, IL-1β, TNF-α significantly associated steatohepatitis (NASH) hepatic fibrosis. Conclusions indicated increased IL‐1β, IL-6, TNF‐α, ICAM-1 concentrations risks These mediators may serve as biomarkers subjects expect provide new insights into aetiology well early diagnosis intervention.

Language: Английский

---

Changes in Glutathione Content in Liver Diseases: An Update

Antioxidants, Journal Year: 2021, Volume and Issue: 10(3), P. 364 - 364

Published: Feb. 28, 2021

Glutathione (GSH), a tripeptide particularly concentrated in the liver, is most important thiol reducing agent involved modulation of redox processes. It has also been demonstrated that GSH cannot be considered only as mere free radical scavenger but it takes part network governing choice between survival, necrosis and apoptosis well altering function signal transduction transcription factor molecules. The purpose present review to provide an overview on molecular biology system; therefore, synthesis, metabolism regulation will reviewed. multiple functions described, importance compartmentalization into distinct subcellular pools inter-organ transfer. Furthermore, we highlight close relationship existing content pathogenesis liver disease, such non-alcoholic fatty disease (NAFLD), alcoholic (ALD), chronic cholestatic injury, ischemia/reperfusion damage, hepatitis C virus (HCV), B (HBV) hepatocellular carcinoma. Finally, potential therapeutic benefits GSH-related medications, described for each disorder taken account.

Language: Английский

---

Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

Free Radical Biology and Medicine, Journal Year: 2019, Volume and Issue: 144, P. 293 - 309

Published: May 29, 2019

Language: Английский

---

Metabolic drivers of non-alcoholic fatty liver disease

Molecular Metabolism, Journal Year: 2020, Volume and Issue: 50, P. 101143 - 101143

Published: Dec. 18, 2020

The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing worldwide parallel to the global obesity epidemic. NAFLD encompasses a range pathologies and most often originates from metabolically driven accumulation fat in liver, or (NAFL). In subset NAFL patients, can progress steatohepatitis (NASH), which more severe form characterized by hepatocyte injury, inflammation, fibrosis. Significant has been made over past decade our understanding NASH pathogenesis, but gaps remain mechanistic knowledge precise metabolic triggers for worsening.

Language: Английский

---

Oxidative Stress Is a Key Modulator in the Development of Nonalcoholic Fatty Liver Disease

Antioxidants, Journal Year: 2021, Volume and Issue: 11(1), P. 91 - 91

Published: Dec. 30, 2021

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress induce progression of to NASH stimulating Kupffer cells, hepatic stellate hepatocytes. Therefore, are underway identify role antioxidants in treatment NAFLD. In this review, we have summarized origins reactive oxygen species (ROS) relationship between ROS NAFLD, discussed use as therapeutic agents for

Language: Английский

---

MASLD and the Development of HCC: Pathogenesis and Therapeutic Challenges

Cancers, Journal Year: 2024, Volume and Issue: 16(2), P. 259 - 259

Published: Jan. 6, 2024

Metabolic-dysfunction-associated steatotic liver disease (MASLD, previously known as non-alcoholic fatty (NAFLD)) represents a rapidly increasing cause of chronic and hepatocellular carcinoma (HCC), mirroring rates obesity metabolic syndrome in the Western world. MASLD-HCC can develop at an earlier stage fibrosis compared to other causes disease, presenting challenges how risk-stratify patients set up effective screening programmes. Therapeutic decision making for is also complicated by medical comorbidities presentation later stage. The response treatment, particularly immune checkpoint inhibitors, may vary aetiology and, future, patient stratification will be key optimizing therapeutic pathways.

Language: Английский

---