Normothermic regional perfusion and liver transplant: expanding the donation after circulatory death donor pool

Current Opinion in Organ Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Purpose of review Normothermic regional perfusion (NRP) is a novel technique developed to improve organ utilization and recipient outcomes following donation after circulatory death (DCD). NRP has revolutionized DCD liver transplant by extending donor criteria reducing the incidence ischemic cholangiopathy (IC) other complications in recipients. However, there significant geographic center-specific variation use practices. This collates practices from pioneering centers across globe regarding selection criteria, techniques, viability monitoring, key areas help guide continued growth transplantation. Recent findings livers recovered using have consistently demonstrated excellent outcomes, with IC patient graft survival rates approaching those seen grafts brain donors. Recently, been working increase pool relaxing limits on quality, reconsidering markers, combining ex situ machine technologies. Summary powerful recovery technology transforming practice Current evidence suggests that could be further expanded recovery, clinical reported less stringent criteria.

Language: Английский

Normothermic Regional Perfusion for Donation After Circulatory Death Liver Transplantation: State of the Art and a Biodesign Framework for Adoption

Current Transplantation Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: May 19, 2025

Language: Английский