Modulation of cell-mediated immunity during pregnancy in wild bonobos DOI Open Access
Verena Behringer, Caroline Deimel, Julia Ostner

et al.

Biology Letters, Journal Year: 2024, Volume and Issue: 20(3)

Published: March 1, 2024

During pregnancy, the mammalian immune system must simultaneously protect against pathogens while being accommodating to foreign fetal tissues. Our current understanding of this modulation derives predominantly from industrialized human populations and laboratory animals. However, their environments differ considerably pathogen-rich, resource-scarce in which pregnancy co-evolved. For a better during challenging environments, we measured urinary neopterin, biomarker cell-mediated responses, 10 wild female bonobos ( Pan paniscus ) before, after pregnancy. Bonobos, sharing evolutionary roots characteristics with humans, serve as an ideal model for such investigation. Despite distinct hypothesized that is similar between humans. As predicted, neopterin levels were higher than outside highest third trimester, significant decline post-partum. findings suggest shared mechanisms humans are robust despite environmental conditions. We propose these patterns indicate immunological processes among hominins, possibly other primates. This finding enhances our reproductive immunology.

Language: Английский

Modulation of cell-mediated immunity during pregnancy in wild bonobos DOI Open Access
Verena Behringer, Caroline Deimel, Julia Ostner

et al.

Biology Letters, Journal Year: 2024, Volume and Issue: 20(3)

Published: March 1, 2024

During pregnancy, the mammalian immune system must simultaneously protect against pathogens while being accommodating to foreign fetal tissues. Our current understanding of this modulation derives predominantly from industrialized human populations and laboratory animals. However, their environments differ considerably pathogen-rich, resource-scarce in which pregnancy co-evolved. For a better during challenging environments, we measured urinary neopterin, biomarker cell-mediated responses, 10 wild female bonobos ( Pan paniscus ) before, after pregnancy. Bonobos, sharing evolutionary roots characteristics with humans, serve as an ideal model for such investigation. Despite distinct hypothesized that is similar between humans. As predicted, neopterin levels were higher than outside highest third trimester, significant decline post-partum. findings suggest shared mechanisms humans are robust despite environmental conditions. We propose these patterns indicate immunological processes among hominins, possibly other primates. This finding enhances our reproductive immunology.

Language: Английский

Citations

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