Does Bitcoin hedge global uncertainty? Evidence from wavelet-based quantile-in-quantile regressions

Finance research letters, Journal Year: 2017, Volume and Issue: 23, P. 87 - 95

Published: Feb. 7, 2017

Language: Английский

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Can volume predict Bitcoin returns and volatility? A quantiles-based approach

Economic Modelling, Journal Year: 2017, Volume and Issue: 64, P. 74 - 81

Published: March 28, 2017

Language: Английский

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Articular cartilage: from formation to tissue engineering

Biomaterials Science, Journal Year: 2016, Volume and Issue: 4(5), P. 734 - 767

Published: Jan. 1, 2016

A summary of the current state cartilage tissue engineering underlying relevant biological aspects that are important for scaffold design.

Language: Английский

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In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Oct. 11, 2019

Abstract Implanted scaffolds with inductive niches can facilitate the recruitment and differentiation of host cells, thereby enhancing endogenous tissue regeneration. Extracellular matrix (ECM) derived from cultured cells or natural tissues exhibit superior biocompatibility trigger favourable immune responses. However, lack hierarchical porous structure fails to provide guidance cues for directional migration spatial organization, consequently limit morpho-functional integration oriented tissues. Here, we engineer ECM parallel microchannels (ECM-C) by subcutaneous implantation sacrificial templates, followed template removal decellularization. The advantages such ECM-C are evidenced close regulation in vitro cell activities, enhanced infiltration vascularization upon vivo implantation. We demonstrate versatility flexibility these regenerating vascularized innervated neo-muscle, neo-nerve pulsatile neo-artery functional integration. This strategy has potential yield inducible biomaterials applications across engineering regenerative medicine.

Language: Английский

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Fundamentals of soft robot locomotion

Journal of The Royal Society Interface, Journal Year: 2017, Volume and Issue: 14(130), P. 20170101 - 20170101

Published: May 1, 2017

Soft robotics and its related technologies enable robot abilities in several domains including, but not exclusively to, manipulation, manufacturing, human–robot interaction locomotion. Although field applications have emerged for soft manipulation interaction, mobile robots appear to remain the research stage, involving somehow conflictual goals of having a deformable body exerting forces on environment achieve This paper aims provide reference guide researchers approaching robotics, describe underlying principles locomotion with pros cons, envisage further developments robotics.

Language: Английский

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Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation

BMC Neuroscience, Journal Year: 2017, Volume and Issue: 18(1)

Published: June 26, 2017

In the recent decade, iron oxide nanoparticles (IONPs) have been proposed for several applications in central nervous system (CNS), including targeting amyloid beta (Aβ) arteries, inhibiting microglial cells, delivering drugs, and increasing contrast magnetic resonance imaging. Conversely, a notable number of studies reported role neurodegenerative diseases. Therefore, this study has reviewed to determine whether IONPs can threaten cellular viability same as iron. Iron contributes Fenton's reaction produces reactive oxygen species (ROS). ROS cause damage macromolecules organelles cell via oxidative stress. accumulation stress are able aggregate some proteins, Aβ α-synuclein, which play critical Alzheimer's Parkinson's diseases, respectively. accumulation, stress, protein aggregation make positive feedback loop, be toxic cell. The release ions from may result targeted tissue, thus, activate loop. However, levels induced toxicity depend on size, concentration, surface charge, type coating functional groups IONPs. depending their properties lead neural cells. order apply CNS, consideration is crucial.

Language: Английский

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Urban spatial order: street network orientation, configuration, and entropy

Applied Network Science, Journal Year: 2019, Volume and Issue: 4(1)

Published: Aug. 23, 2019

Street networks may be planned according to clear organizing principles or they evolve organically through accretion, but their configurations and orientations help define a city's spatial logic order. Measures of entropy reveal streets' order disorder. Past studies have explored individual cases orientation entropy, little is known about broader patterns trends worldwide. This study examines street network orientation, configuration, in 100 cities around the world using OpenStreetMap data OSMnx. It measures bearings weighted unweighted models, along with each typical segment length, average circuity, node degree, network's proportions four-way intersections dead-ends. also develops new indicator orientation-order that quantifies how follows geometric ordering single grid. A cluster analysis performed explore similarities differences among these sites multiple dimensions. Significant statistical relationships exist between city other indicators order, including circuity connectedness. On average, US/Canadian are far more grid-like than those elsewhere, exhibiting less circuity. These indicators, taken concert, extent nuance methods demonstrate automatic, scalable, reproducible tools empirically measure visualize illustrating complex urban transportation system world.

Language: Английский

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From ice-binding proteins to bio-inspired antifreeze materials

Soft Matter, Journal Year: 2017, Volume and Issue: 13(28), P. 4808 - 4823

Published: Jan. 1, 2017

Ice-binding proteins (IBP) facilitate survival under extreme conditions in diverse life forms. Successful translation of this natural cryoprotective ability into man-made materials would open up new avenues biomedicine, agrifood and science. This review covers recent advances the field IBPs their synthetic analogues, focusing on fundamental insights biological technological relevance.

Language: Английский

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Plasmalogen lipids: functional mechanism and their involvement in gastrointestinal cancer

Lipids in Health and Disease, Journal Year: 2018, Volume and Issue: 17(1)

Published: March 7, 2018

The plasmalogens are a class of glycerophospholipids which contain vinyl-ether and an ester bond at the sn-1 sn-2 positions, respectively, in glycerol backbone. They constitute 10 mol% total mass phospholipids humans, mainly as membrane structure components. Plasmalogens important for organization stability lipid raft microdomains cholesterol-rich regions involved cellular signaling. In addition to their structural roles, subset ether lipids thought function endogenous antioxidants emerging studies suggest that they cell differentiation signaling pathways. Although clinical significance is linked peroxisomal disorders, pathophysiological roles possible metabolic pathways not fully understood since present unique attributes different tissue types. Studies changes plasmalogen metabolism may contribute development various types cancer. Here, we review molecular characteristics order significantly increase our understanding molecule its involvement gastrointestinal cancers well other cancers.

Language: Английский

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PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia

Nature Communications, Journal Year: 2016, Volume and Issue: 7(1)

Published: Nov. 29, 2016

Activin receptor-like kinase 1 (ALK1) is an endothelial serine-threonine receptor for bone morphogenetic proteins (BMPs) 9 and 10. Inactivating mutations in the ALK1 gene cause hereditary haemorrhagic telangiectasia type 2 (HHT2), a disabling disease characterized by excessive angiogenesis with arteriovenous malformations (AVMs). Here we show that inducible, endothelial-specific homozygous Alk1 inactivation BMP9/10 ligand blockade both lead to AVM formation postnatal retinal vessels internal organs including gastrointestinal (GI) tract mice. VEGF PI3K/AKT signalling are increased on deletion blockade. Genetic of signal-transducing Vegfr2 prevents but does not fully revert formation. In contrast, pharmacological PI3K inhibition efficiently reverts established AVMs. Thus, leads pathway activation may be novel target treatment vascular lesions HHT2.

Language: Английский

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