The impact of ventilation systems on the risk of viral transmission (review article) DOI Open Access
Darya Abramkina,

Vishal Verma

Ekologiya Cheloveka (Human Ecology), Journal Year: 2024, Volume and Issue: 31(6), P. 419 - 428

Published: Dec. 25, 2024

Understanding the aerosol transmission mechanism of respiratory infectious diseases is crucial for predicting indoor air circulation and optimizing ventilation system design. A literature search was conducted using various keyword combinations in PubMed database. The selection included studies examining impact microclimate parameters performance on risk viral transmission. Since 2020, there has been increasing interest studying how infections spread via aerosols within buildings transportation infrastructure, considering operational conditions engineering systems. Currently, substantial evidence supports dependence viability temperature humidity levels. Maintaining an optimal relative 40–60% at standard room essential not only stability but also virus neutralization. However, a lack investigating effects mobility pollution pathogens. significant body confirms influence efficiency infection buildings. To reduce viruses, exchange rate least 30 m3/h per person recommended. Based findings, set practical recommendations operation amidst increased disease incidence developed. Discrepancies between international Russian regulatory requirements regarding climate quality standards have identified, emphasizing need improved measures to mitigate infections.

Language: Английский

Review of factors affecting virus inactivation in aerosols and droplets DOI Creative Commons
Alexandra Longest, Nicole C. Rockey, Seema S. Lakdawala

et al.

Journal of The Royal Society Interface, Journal Year: 2024, Volume and Issue: 21(215)

Published: June 1, 2024

The inactivation of viruses in aerosol particles (aerosols) and droplets depends on many factors, but the precise mechanisms are not known. system involves complex physical biochemical interactions. We reviewed literature to establish current knowledge about these identify gaps. identified 168 relevant papers grouped results by following factors: virus type structure, or droplet size, temperature, relative humidity (RH) evaporation, chemical composition droplet, pH atmospheric composition. These factors influence dynamic microenvironment surrounding a virion thus may affect its inactivation. Results indicate that experience biphasic decay as carrier aerosols undergo evaporation equilibrate with air, their final state (liquid, semi-solid solid) RH. Virus stability, RH temperature interrelated, effects multifaceted still completely understood. Studies impact stability have raised new questions require further exploration. frequent practice studying large culture media limit our understanding for transmission, so we encourage use physiologically size future research.

Language: Английский

Citations

8
Mucin Colocalizes with Influenza Virus and Preserves Infectivity in Deposited Model Respiratory Droplets DOI
Jin Pan, Nisha K. Duggal, Seema S. Lakdawala

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The stability of influenza virus in respiratory particles varies with relative humidity (RH) and protein content. This study investigated the decay, or loss infectivity, A (IAV) 1-μL droplets deposited on a surface varying concentrations mucin, one most abundant proteins mucus, examined localization virions within droplets. IAV remained stable at 0.1% 0.5% mucin phosphate-buffered saline (PBS) over 4 h 20%, 50%, 80% RH, maximum decay 1.2 log10/mL. In contrast, pure PBS droplets, decayed by least 2.6 log10/mL after 50% RH. Mucin's protective effect was independent its concentration, except RH h. Confocal microscopy revealed that 20% led to thicker coffee rings dendritic patterns where colocalized mucin. At no morphological difference observed between PBS-only mucin-containing but still center Analysis digital droplet PCR showed helped maintain integrity. To our knowledge, this is first localize model results suggest mucin's colocalization may protect from environmental stressors, enhancing stability.

Language: Английский

Citations

0
Indoor air sampling for detection of viral nucleic acids DOI Creative Commons
Lennart Justen, Simon L. Grimm, Kevin M. Esvelt

et al.

Journal of Aerosol Science, Journal Year: 2025, Volume and Issue: unknown, P. 106549 - 106549

Published: Feb. 1, 2025

Language: Английский

Citations

0
Modeling and Possible Control of Droplet-Mediated Spread of Respiratory Viruses by the Study of the Environmental Conditions in Closed Rooms DOI Creative Commons
Carlo Pirola,

Franco Manenti,

F. Maestri

et al.

International Journal of Thermofluids, Journal Year: 2025, Volume and Issue: unknown, P. 101174 - 101174

Published: March 1, 2025

Language: Английский

Citations

0
Destruction of Virus Particles via Mechanical and Chemical Virucidal Activity of Nanocolumnar Copper Thin Films DOI Creative Commons
Keisuke Shigetoh, Yusuke Hirata, Nobuhiko Muramoto

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101803 - 101803

Published: April 1, 2025

Language: Английский

Citations

0
Airborne bioaerosols in healthcare facilities – transmission routes and mitigation strategies. A review DOI Creative Commons
Marcin Janczarek, Agnieszka Ślosarczyk, Izabela Klapiszewska

et al.

Journal of Building Engineering, Journal Year: 2024, Volume and Issue: 97, P. 111015 - 111015

Published: Oct. 10, 2024

Language: Английский

Citations

1
Administration of airborne pathogens in non-human primates DOI

Justina Creppy,

Benoît Delache,

Julien Lemaître

et al.

Inhalation Toxicology, Journal Year: 2024, Volume and Issue: 36(9-10), P. 475 - 500

Published: Oct. 10, 2024

Purpose Airborne pathogen scan penetrate in human respiratory tract and can cause illness. The use of animal models to predict aerosol deposition study disease pathophysiology is therefore important for research a prerequisite test the mechanism action treatment. NHPs are relevant species inhalation studies because their similarities with humans terms anatomical structure, parameters immune system.

Language: Английский

Citations

0
The impact of ventilation systems on the risk of viral transmission (review article) DOI Open Access
Darya Abramkina,

Vishal Verma

Ekologiya Cheloveka (Human Ecology), Journal Year: 2024, Volume and Issue: 31(6), P. 419 - 428

Published: Dec. 25, 2024

Understanding the aerosol transmission mechanism of respiratory infectious diseases is crucial for predicting indoor air circulation and optimizing ventilation system design. A literature search was conducted using various keyword combinations in PubMed database. The selection included studies examining impact microclimate parameters performance on risk viral transmission. Since 2020, there has been increasing interest studying how infections spread via aerosols within buildings transportation infrastructure, considering operational conditions engineering systems. Currently, substantial evidence supports dependence viability temperature humidity levels. Maintaining an optimal relative 40–60% at standard room essential not only stability but also virus neutralization. However, a lack investigating effects mobility pollution pathogens. significant body confirms influence efficiency infection buildings. To reduce viruses, exchange rate least 30 m3/h per person recommended. Based findings, set practical recommendations operation amidst increased disease incidence developed. Discrepancies between international Russian regulatory requirements regarding climate quality standards have identified, emphasizing need improved measures to mitigate infections.

Language: Английский

Citations

0