Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIV DOI Creative Commons
Deepti Kannan, Eric Wang, Steven G. Deeks

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

SUMMARY Antiretroviral therapy (ART) inhibits Human Immunodeficiency Virus (HIV) replication to maintain undetectable viral loads in people living with HIV, but does not result a cure. Due the significant challenges of lifelong ART for many, there is strong interest therapeutic strategies that Recent clinical trials have shown administration broadly neutralizing antibodies (bnAbs) when some viremia can lead ART-free control people; however, underlying mechanisms are unclear. Our computational modeling shows bnAbs administered presence promote evolution autologous (aAbs) target diverse epitopes HIV spike proteins. This “net” polyclonal aAbs could confer since evasion this response would require developing mutations multiple epitopes. results provide common mechanistic framework recent observations upon bnAb/ART therapy, and they should also motivate inform new trials.

Language: Английский

Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIV DOI Creative Commons
Deepti Kannan, Eric Wang, Steven G. Deeks

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

SUMMARY Antiretroviral therapy (ART) inhibits Human Immunodeficiency Virus (HIV) replication to maintain undetectable viral loads in people living with HIV, but does not result a cure. Due the significant challenges of lifelong ART for many, there is strong interest therapeutic strategies that Recent clinical trials have shown administration broadly neutralizing antibodies (bnAbs) when some viremia can lead ART-free control people; however, underlying mechanisms are unclear. Our computational modeling shows bnAbs administered presence promote evolution autologous (aAbs) target diverse epitopes HIV spike proteins. This “net” polyclonal aAbs could confer since evasion this response would require developing mutations multiple epitopes. results provide common mechanistic framework recent observations upon bnAb/ART therapy, and they should also motivate inform new trials.

Language: Английский

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