General and Anxiety-Linked Influence of Acute Serotonin Reuptake Inhibition on Neural Responses Associated with Attended Visceral Sensation

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 23, 2024

Abstract Serotonin is known to have state-dependent modulatory influences on exteroceptive sensory processes and the processing of pain, but much less about its role in ordinary interoceptive their relationships affective states. This experiment compared impact a selective serotonin reuptake inhibitor (SSRI) (20mg CITALOPRAM), acutely increasing extracellular serotonin, that PLACEBO neural sensations relationship these anxious Twenty-one healthy young volunteers completed visceral attention (VIA) task with each treatment, focusing heart, stomach, or visual sensation control while scanned functional magnetic resonance imaging (fMRI). The relative response (IR) heart [heart minus visual] stomach [stomach were between treatment conditions, controlling for general effects processing. CITALOPRAM reduced viscerosensory (bilateral posterior insular cortex, stomach-IR) integrative/affective components amygdala, stomach-IR heart-IR) pathways. We then searched varied current levels anxiety. anterior cortex increased anxiety, replicating prior findings. disappeared CITALOPRAM. Preliminary post hoc exploration found CITALOPRAM’S amygdalae predicted acute increases decreases Overall, this evidence serotonergic influence advances our understanding interoception, regulation,

Language: Английский

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Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies

Frontiers in Pain Research, Journal Year: 2024, Volume and Issue: 5

Published: April 19, 2024

Despite research advances and urgent calls by national global health organizations, clinical outcomes for millions of people suffering with chronic pain remain poor. We suggest bringing the lens complexity science to this problem, conceptualizing as an emergent property a complex biopsychosocial system. frame pain-related physiology, neuroscience, developmental psychology, learning, epigenetics components mini-systems that interact together changing socioenvironmental conditions, overarching system gives rise phenomenon pain. postulate behavior systems may help explain persistence despite current treatments. From perspective, benefit from therapies can be both disruptive adaptive at higher orders within explore psychedelic-assisted how these overlap complement mindfulness-based approaches end. Both mindfulness psychedelic have been shown transdiagnostic value, due in part effects on rigid cognitive, emotional, behavioral patterns well their ability promote neuroplasticity. Psychedelic hold unique promise management

Language: Английский

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The Utility of Heartrate and Heartrate Variability Biofeedback for the Improvement of Interoception across Behavioural, Physiological and Neural Outcome Measures: A Systematic Review

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 579 - 579

Published: June 5, 2024

Interoceptive dysfunctions are increasingly implicated in a number of physical and mental health conditions. Accordingly, there is pertinent need for therapeutic interventions which target interoceptive deficits. Heartrate heartrate variability biofeedback therapy (HR(V)-BF), train individuals to regulate their cardiovascular signals constrain these within optimal parameters through breathing, could enhance the functioning pathways via stimulation vagus nerve. Consequently, this narrative systematic review sought synthesise current state literature with regard potential HR(V)-BF as an intervention across behavioural, physiological neural outcome measures related interoception. In total, 77 papers were included review, majority using measures. Overall, findings mixed respect improvements after HR(V)-BF. However, trends suggested that effects on interoception stronger when resonance frequency breathing intense treatment protocol employed. Based findings, we propose three-stage model by may improve draws upon principles inference predictive coding. Furthermore, provide specific directions future research, will serve advance knowledge state.

Language: Английский

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General and anxiety-linked influences of acute serotonin reuptake inhibition on neural responses associated with attended visceral sensation

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 6, 2024

Abstract Ordinary sensations from inside the body are important causes and consequences of our affective states behaviour, yet roles neurotransmitters in interoceptive processing have been unclear. With a within-subjects design, this experiment tested impacts acute increases endogenous extracellular serotonin on neural attended internal links these effects to anxiety using selective reuptake inhibitor (SSRI) (20 mg citalopram ) placebo . Twenty-one healthy volunteers (fourteen female, mean age 23.9) completed Visceral Interoceptive Attention (VIA) task while undergoing functional magnetic resonance imaging (fMRI) with each treatment. The VIA required focused attention heart, stomach, or visual sensation. relative responses heart sensation [heart minus attention] (heart-IR) stomach [stomach (stomach-IR) were compared between treatments. Visual subtraction controlled for general sensory processing. Citalopram was associated lower viscerosensory (the stomach-IR bilateral posterior insular cortex) integrative/affective heart-IR amygdala) components pathways. In anterior cortex, reductions depended levels, removing previously known association region’s response observed Preliminary post hoc analysis indicated that amygdalae corresponded changes. This direct evidence anxiety-linked serotonergic influence processes advances understanding interoception, its regulation, anxiety.

Language: Английский

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Heart Rate Variability and Interoception in Periodic Limb Movements in Sleep: Interference with Psychiatric Disorders?

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6129 - 6129

Published: Oct. 14, 2024

Periodic limb movements in sleep (PLMS) are a prevalent disorder characterized by rhythmic, involuntary of the lower limbs, such as dorsiflexion ankle and extension big toe, occurring periodic intervals during sleep. These often linked to disrupted autonomic nervous system (ANS) activity altered interoception. Interoception involves perceiving internal bodily states, like heartbeat, breathing, hunger, temperature, plays crucial role maintaining homeostasis mind-body connection. This review explores complex relationships between PLMS, heart rate variability (HRV), ANS dysregulation, their impact on psychiatric disorders. By synthesizing existing literature, it provides insights into how dysregulation interoceptive processes, alongside contribute conditions. The highlights potential for integrated diagnostic therapeutic approaches presents cause-and-effect model illustrating mutual influence disorders,

Language: Английский

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Top-down circuitry from the anterior insular cortex to VTA dopamine neurons modulates reward-related memory

Cell Reports, Journal Year: 2023, Volume and Issue: 42(11), P. 113365 - 113365

Published: Nov. 1, 2023

The insular cortex (IC) has been linked to the processing of interoceptive and exteroceptive signals associated with addictive behavior. However, whether IC modulates acquisition drug-related affective states by direct top-down connectivity ventral tegmental area (VTA) dopamine neurons is unknown. We found that photostimulation VTA terminals anterior (aIC) induces rewarding contextual memory, activity, triggers release within VTA. Employing neuronal recordings neurochemical transsynaptic tagging techniques, we disclose functional organization aIC pre-synaptic bodies identifying recipient neurons. Furthermore, systemic administration amphetamine altered excitability modulated projection, where photoactivation enhances, whereas photoinhibition impairs, a Our study reveals key circuit involved in developing retaining drug reward-related providing insight into neurobiological basis behavior helping develop therapeutic addiction strategies.

Language: Английский

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The neuroanatomy of social trust predicts depression vulnerability

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Oct. 6, 2022

Abstract Trust attitude is a social personality trait linked with the estimation of others’ trustworthiness. Trusting others, however, can have substantial negative effects on mental health, such as development depression. Despite significant progress in understanding neurobiology trust, whether neuroanatomy trust depression vulnerability remains unknown. To investigate link between and vulnerability, we assessed depressive symptoms employed neuroimaging to acquire brain structure data healthy participants. A high symptom score was used an indicator vulnerability. The neuroanatomical results observed sample were validated clinically diagnosed patients. We found significantly higher among low trusters than trusters. Neuroanatomically, patients showed similar volume reduction regions implicated cognition, including dorsolateral prefrontal cortex (DLPFC), dorsomedial PFC, posterior cingulate, precuneus, angular gyrus. Furthermore, reduced DLPFC precuneus mediated relationship symptoms. These findings contribute social- neural-markers may inform interventions prevent pathological

Language: Английский

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Physical Exercise to Redynamize Interoception in Substance use Disorders

Current Neuropharmacology, Journal Year: 2023, Volume and Issue: 22(6), P. 1047 - 1063

Published: March 15, 2023

Physical exercise is considered a promising medication-free and cost-effective adjunct treatment for substance use disorders (SUD). Nevertheless, evidence regarding the effectiveness of these interventions currently limited, thereby signaling need to better understand mechanisms underlying their impact on SUD, in order reframe optimize them. Here we advance that physical could be re-conceptualized as an "interoception booster", namely way help people with SUD decode interpret bodily-related signals associated transient states homeostatic imbalances usually trigger consumption. We first discuss how mismatches between current desired bodily influence formation reward-seeking light insular cortex brain networks. Next, detail effort perception during it can used relevant framework re-dynamizing interoception SUD. conclude by providing perspectives methodological considerations applying proposed approach mixed-design neurocognitive research

Language: Английский

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Filling in the vacuous flesh: Embodiment, constitution, and interoception

Theory & Psychology, Journal Year: 2023, Volume and Issue: 33(4), P. 515 - 534

Published: April 29, 2023

To many scientists and philosophers, embodied cognition lacks validity, since it fails to offer extraordinary evidence. In this article, we claim that the development of one possible evidence-based could initiate a considerable research project through inner workings bodily constitutive neuro-machinery. We call “interoceptive cognition”; here, concept interoception plays role filling in (inner) gap vacuous embodiment. The most important tenet for our purpose is standard constitution which will repeatedly return. look back three standards then regard as filling-in echoing cognition. demonstrate varieties constituents interoception. Next, present interoception’s close relationship at least four subdomains cognition, include: (a) sense embodiment, (b) self, (c) emotion, (d) social Finally, conclude with preliminaries interoceptive

Language: Английский

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Physiological Needs: Sensations and Predictions in the Insular Cortex

Physiology, Journal Year: 2022, Volume and Issue: 38(2), P. 73 - 81

Published: Aug. 30, 2022

Physiological needs create powerful motivations (e.g., thirst and hunger). Studies in humans animal models have implicated the insular cortex neural regulation of physiological need-driven behavior. We review prominent mechanistic how might achieve this present a conceptual analytical framework for testing these healthy pathological conditions.

Language: Английский

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