De-stabilizing innate immunity in COVID-19: effects of its own positive feedback and erratic viraemia on the alternative pathway of complement DOI Creative Commons
J. Reeve

Royal Society Open Science, Journal Year: 2024, Volume and Issue: 11(1)

Published: Jan. 1, 2024

Complement provides powerful, fast responses in the human circulation to SARS-CoV-2 (COVID-19 virus) infection of lower respiratory tract. COVID-19 effects were investigated a revised silico Mass Action model complement's alternative pathway (AP) responses. Bursts newly circulating virions increased fission protein C3 into C3a and C3b via stimulation lectin or inhibited complement factor H. Viral reproduction sub-models incorporated smoothly exponential step-wise growth. Starting concentrations drawn randomly from published normal male female ranges each run for 10 days. B (FB) syntheses driven by Lectin Pathway led declining plasma increasing FB concentrations. The C3-convertase concentration, driver viral elimination, could match growth over three orders magnitude but near-complete exhaustion was more prevalent with than ‘smooth’ increases stimulation. be prolonged. Type 2 Diabetes hypertension greatly peak concentrations, as did short-term variability viraemia, pulmonary capillary clotting secondary acidosis. Positive feedback AP extends its response range at expense stability.

Language: Английский

De-stabilizing innate immunity in COVID-19: effects of its own positive feedback and erratic viraemia on the alternative pathway of complement DOI Creative Commons
J. Reeve

Royal Society Open Science, Journal Year: 2024, Volume and Issue: 11(1)

Published: Jan. 1, 2024

Complement provides powerful, fast responses in the human circulation to SARS-CoV-2 (COVID-19 virus) infection of lower respiratory tract. COVID-19 effects were investigated a revised silico Mass Action model complement's alternative pathway (AP) responses. Bursts newly circulating virions increased fission protein C3 into C3a and C3b via stimulation lectin or inhibited complement factor H. Viral reproduction sub-models incorporated smoothly exponential step-wise growth. Starting concentrations drawn randomly from published normal male female ranges each run for 10 days. B (FB) syntheses driven by Lectin Pathway led declining plasma increasing FB concentrations. The C3-convertase concentration, driver viral elimination, could match growth over three orders magnitude but near-complete exhaustion was more prevalent with than ‘smooth’ increases stimulation. be prolonged. Type 2 Diabetes hypertension greatly peak concentrations, as did short-term variability viraemia, pulmonary capillary clotting secondary acidosis. Positive feedback AP extends its response range at expense stability.

Language: Английский

Citations

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