Genotype and Phenotype Characterization of Rhinolophus sp. Sarbecoviruses from Vietnam: Implications for Coronavirus Emergence DOI Creative Commons
Sarah Temmam,

Tran Cong Tu,

Béatrice Regnault

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(9), P. 1897 - 1897

Published: Sept. 8, 2023

Bats are a major reservoir of zoonotic viruses, including coronaviruses. Since the emergence SARS-CoV in 2002/2003 Asia, important efforts have been made to describe diversity Coronaviridae circulating bats worldwide, leading discovery precursors epidemic and pandemic sarbecoviruses horseshoe bats. We investigated viral communities infecting living Northern Vietnam, report here first identification Rhinolophus thomasi siamensis Phylogenetic characterization seven strains Vietnamese identified at least three clusters viruses. Recombination cross-species transmission between seemed constitute drivers virus evolution. were mainly enteric, therefore constituting risk spillover for guano collectors or people visiting caves. To evaluate potential these we analyzed silico vitro ability their RBDs bind mammalian ACE2s concluded that viruses likely restricted bat hosts. The workflow applied characterize novel is interest each time new discovered, order concentrate surveillance on high-risk interfaces.

Language: Английский

Developing One Health surveillance systems DOI Creative Commons
David T. S. Hayman, Wiku Adisasmito, Salama Almuhairi

et al.

One Health, Journal Year: 2023, Volume and Issue: 17, P. 100617 - 100617

Published: Aug. 21, 2023

The health of humans, domestic and wild animals, plants, the environment are inter-dependent. Global anthropogenic change is a key driver disease emergence spread leads to biodiversity loss ecosystem function degradation, which themselves drivers emergence. Pathogen spill-over events subsequent outbreaks, including pandemics, in animals plants may arise when factors driving converge. One Health an integrated approach that aims sustainably balance optimize human, animal health. Conventional surveillance has been siloed by sectors, with separate systems addressing cultivated wildlife environment. should include for known unknown pathogens, but combined this more traditional disease-based surveillance, it also must improve prevention mitigation events. Here, we outline such approach, characteristics components required overcome barriers system.

Language: Английский

Citations

66
Biodiversity conservation in the context of climate change: Facing challenges and management strategies DOI
Z. Wang, Tongxin Wang, Xiujuan Zhang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 937, P. 173377 - 173377

Published: May 23, 2024

Language: Английский

Citations

36
Climate change extinctions DOI Creative Commons
Mark C. Urban

Science, Journal Year: 2024, Volume and Issue: 386(6726), P. 1123 - 1128

Published: Dec. 5, 2024

Climate change is expected to cause irreversible changes biodiversity, but predicting those risks remains uncertain. I synthesized 485 studies and more than 5 million projections produce a quantitative global assessment of climate extinctions. With increased certainty, this meta-analysis suggests that extinctions will accelerate rapidly if temperatures exceed 1.5°C. The highest-emission scenario would threaten approximately one-third species, globally. Amphibians; species from mountain, island, freshwater ecosystems; inhabiting South America, Australia, New Zealand face the greatest threats. In line with predictions, has contributed an increasing proportion observed since 1970. Besides limiting greenhouse gases, pinpointing which protect first be critical for preserving biodiversity until anthropogenic halted reversed.

Language: Английский

Citations

20
A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia DOI Creative Commons
Cecilia A. Sánchez, Hongying Li, Kendra L. Phelps

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 9, 2022

Emerging diseases caused by coronaviruses of likely bat origin (e.g., SARS, MERS, SADS, COVID-19) have disrupted global health and economies for two decades. Evidence suggests that some SARS-related (SARSr-CoVs) could infect people directly, their spillover is more frequent than previously recognized. Each zoonotic a novel virus represents an opportunity evolutionary adaptation further spread; therefore, quantifying the extent this may help target prevention programs. We derive current range distributions known SARSr-CoV hosts quantify overlap with human populations. then use probabilistic risk assessment data on human-bat contact, viral seroprevalence, antibody duration to estimate median 66,280 (95% CI: 65,351-67,131) are infected SARSr-CoVs annually in Southeast Asia. These geography scale can be used surveillance programs potential future bat-CoV emergence.

Language: Английский

Citations

61
Present and future distribution of bat hosts of sarbecoviruses: implications for conservation and public health DOI Creative Commons
Renata L. Muylaert, Tigga Kingston, Jinhong Luo

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2022, Volume and Issue: 289(1975)

Published: May 25, 2022

Global changes in response to human encroachment into natural habitats and carbon emissions are driving the biodiversity extinction crisis increasing disease emergence risk. Host distributions one critical component identify areas at risk of viral spillover, bats act as reservoirs diverse viruses. We developed a reproducible ecological niche modelling pipeline for bat hosts SARS-like viruses (subgenus

Language: Английский

Citations

24
Human disturbance increases coronavirus prevalence in bats DOI Creative Commons
Vera Warmuth, Dirk Metzler, Veronica Zamora‐Gutierrez

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(13)

Published: March 31, 2023

Human land modification is a known driver of animal-to-human transmission infectious agents (zoonotic spillover). Infection prevalence in the reservoir key predictor spillover, but landscape-level associations between intensity and infection rates wildlife remain largely untested. Bat-borne coronaviruses have caused three major disease outbreaks humans: severe acute respiratory syndrome (SARS), Middle East syndrome, coronavirus 2019 (COVID-19). We statistically link high-resolution data with bat surveillance records show that significantly increases human impact across all climates levels background biodiversity. The most significant contributors to overall are agriculture, deforestation, mining. Regions high predicted coincide global hotspots, suggesting may be an important factor underlying links zoonotic emergence.

Language: Английский

Citations

14
Using drivers and transmission pathways to identify SARS-like coronavirus spillover risk hotspots DOI Creative Commons
Renata L. Muylaert, David A. Wilkinson, Tigga Kingston

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 27, 2023

The emergence of SARS-like coronaviruses is a multi-stage process from wildlife reservoirs to people. Here we characterize multiple drivers-landscape change, host distribution, and human exposure-associated with the risk spillover zoonotic help inform surveillance mitigation activities. We consider direct indirect transmission pathways by modeling four scenarios livestock mammalian as potential known before examining how access healthcare varies within clusters scenarios. found 19 differing factor contributions single country (N = 9) or transboundary 10). High-risk areas were mainly closer (11-20%) rather than far ( < 1%) healthcare. Areas reveal inequalities, especially Scenario 3, which includes wild mammals not secondary hosts. China 2) Indonesia 1) had highest risk. Our findings can stakeholders in land use planning, integrating implementation One Health actions.

Language: Английский

Citations

12
Advances in understanding bat infection dynamics across biological scales DOI Creative Commons
Cecilia A. Sánchez, Kendra L. Phelps, Hannah K. Frank

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 291(2018)

Published: March 6, 2024

Over the past two decades, research on bat-associated microbes such as viruses, bacteria and fungi has dramatically increased. Here, we synthesize themes from a conference symposium focused advances in of bats their microbes, including physiological, immunological, ecological epidemiological that improved our understanding bat infection dynamics at multiple biological scales. We first present metrics for measuring individual responses to challenges associated with using these metrics. next discuss within populations same species, before introducing complexities arise multi-species communities bats, humans and/or livestock. Finally, outline critical gaps opportunities future interdisciplinary work topics involving microbes.

Language: Английский

Citations

5
An immediate way to lower pandemic risk: (not) seizing the low-hanging fruit (bat) DOI Creative Commons

Steven A. Osofsky,

Susan Lieberman, Chris Walzer

et al.

The Lancet Planetary Health, Journal Year: 2023, Volume and Issue: 7(6), P. e518 - e526

Published: June 1, 2023

What is the least that humanity can do to mitigate risks of future pandemics, prevent worldwide surges in human deaths, illness, and suffering—and more waves multitrillion US dollar impacts on global economy? The issues around our consumption trading wildlife are diverse complex, with many rural communities being dependent wild meat for their nutritional needs. But bats might be one taxonomic group successfully eliminated from diet other uses, minimal costs or inconvenience vast majority 8 billion people Earth. order Chiroptera merits genuine respect given all these species contribute food supplies through pollination services provided by frugivores disease risk mitigation delivered insectivorous species. community missed its chance stop SARS-CoV SARS-CoV-2 emerging—how times will allow this cycle repeat? How long governments ignore science front them? It's past time humans done. A taboo needed whereby agrees leave alone, not fear them try chase away cull them, but let have habitats they need live undisturbed humans.

Language: Английский

Citations

11
The coevolutionary mosaic of bat betacoronavirus emergence risk DOI Creative Commons

Norma Rocio Forero-Muñoz,

Renata L. Muylaert, Stephanie N. Seifert

et al.

Virus Evolution, Journal Year: 2023, Volume and Issue: 10(1)

Published: Dec. 20, 2023

Abstract Pathogen evolution is one of the least predictable components disease emergence, particularly in nature. Here, building on principles established by geographic mosaic theory coevolution, we develop a quantitative, spatially explicit framework for mapping evolutionary risk viral emergence. Driven interest diseases like Severe Acute Respiratory Syndrome (SARS), Middle East (MERS), and Coronavirus 2019 (COVID-19), examine global biogeography bat-origin betacoronaviruses, find that coevolutionary suggest geographies are distinct from hotspots coldspots host richness. Further, our helps explain patterns unique pool merbecoviruses Neotropics, recently discovered lineage divergent nobecoviruses Madagascar, and—most importantly—hotspots diversification southeast Asia, sub-Saharan Africa, correspond to site previous zoonotic emergence events. Our may help identify future have also been previously overlooked, West Africa Indian subcontinent, more broadly researchers understand how ecology shapes diversity pandemic threats.

Language: Английский

Citations

9