Across two continents: The genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas DOI Creative Commons
Yocelyn T. Gutiérrez‐Guerrero, Megan Phifer‐Rixey, Michael W. Nachman

et al.

PLoS Genetics, Journal Year: 2024, Volume and Issue: 20(7), P. e1011036 - e1011036

Published: July 5, 2024

Replicated clines across environmental gradients can be strong evidence of adaptation. House mice ( Mus musculus domesticus ) were introduced to the Americas by European colonizers and are now widely distributed from Tierra del Fuego Alaska. Multiple aspects climate, such as temperature, vary predictably latitude in Americas. Past studies North American populations latitudinal provided adaptation traits related body size, metabolism, behavior identified candidate genes using selection scans. Here, we investigate genomic signals on a second continent, South America, ask whether there is parallel multiple transects We first loci genome showing signatures climatic variation sampled transect accounting for neutral population structure. Consistent with previous results, most SNPs putatively regulatory regions. Genes that contained extreme outliers relate weight or immunity, fat, eye function, cardiovascular system. then compared these results analyses published data two America. While unique individual transects, found significant overlap among independently three transects. These diverse, functions relating cardiac circadian rhythm, others. also shifts allele frequency gradients. Finally, combining all several associated weight. Overall, our provide shared responses identify likely underlie recent house

Language: Английский

Parallel evolution despite low genetic diversity in three-spined sticklebacks DOI Creative Commons
Carla Coll-Costa, Carolin Dahms, Petri Kemppainen

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 291(2020)

Published: April 9, 2024

When populations repeatedly adapt to similar environments they can evolve phenotypes based on shared genetic mechanisms (parallel evolution). The likelihood of parallel evolution is affected by demographic history, as it depends the standing variation source population. three-spined stickleback (

Language: Английский

Citations

4
The interplay between epigenomic and transcriptomic variation during ecotype divergence in stickleback DOI Creative Commons
Man Luo, Junjie Zhao, Juha Merilä

et al.

BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 5, 2025

Populations colonizing contrasting environments are likely to undergo adaptive divergence and evolve ecotypes with locally adapted phenotypes. While diverse molecular mechanisms underlying ecotype have been identified, less is known about their interplay degree of divergence. Here we integrated epigenomic transcriptomic data explore the interactions among gene expression, alternative splicing, DNA methylation, microRNA expression gauge extent which patterns at four levels aligned in a case postglacial between marine freshwater nine-spined sticklebacks (Pungitius pungitius). Despite significant genome-wide associations variation, found largely non-parallel across levels, predominantly nonoverlapping (ranging from 43.40 87.98%) sets differentially expressed, spliced methylated genes, candidate genes targeted by expressed miRNA ecotypes. Furthermore, variation different mechanisms, differential methylation splicing showing highest lowest ecotypes, respectively. Finally, enrichment associated methylation. Our results suggest nuanced relationship processes, alignment level masking relatively independent effects on level.

Language: Английский

Citations

0
Ecological genetics of isolated loach populations indicate compromised adaptive potential DOI Creative Commons
Xi Wang, Kerry Reid, Ying Chen

et al.

Heredity, Journal Year: 2024, Volume and Issue: 133(2), P. 88 - 98

Published: July 3, 2024

Abstract Many endangered species live in fragmented and isolated populations with low genetic variability, signs of inbreeding, small effective population sizes - all features elevating their extinction risk. The flat-headed loach ( Oreonectes platycephalus) , a noemacheilid fish, is widely across southern China, but only the headwaters hillstreams; as result, they are spatially from conspecific populations. We surveyed single nucleotide polymorphisms 16 Hong Kong O. platycephalus to determine whether different streams were genetically each other, showed levels diversity, had contemporary sizes. Estimates average observed heterozygosity H O = 0.0473), weighted diversity π w 0.0546) N e 10.2 ~ 129.8) very low, several clear inbreeding judged relatedness estimates. degree differentiation among was high (average F ST 0.668), even over short geographic distances (<1.5 km), patterns isolation by distance. These results suggest that have experienced strong drift loss variability because sea-level rise after last glaciation reduced connectedness paleodrainages, isolating headwaters. All this, together fact within lower than most other freshwater fishes, suggests face local risk limited capacity for future adaptation.

Language: Английский

Citations

2
Across two continents: The genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas DOI Creative Commons
Yocelyn T. Gutiérrez‐Guerrero, Megan Phifer‐Rixey, Michael W. Nachman

et al.

PLoS Genetics, Journal Year: 2024, Volume and Issue: 20(7), P. e1011036 - e1011036

Published: July 5, 2024

Replicated clines across environmental gradients can be strong evidence of adaptation. House mice ( Mus musculus domesticus ) were introduced to the Americas by European colonizers and are now widely distributed from Tierra del Fuego Alaska. Multiple aspects climate, such as temperature, vary predictably latitude in Americas. Past studies North American populations latitudinal provided adaptation traits related body size, metabolism, behavior identified candidate genes using selection scans. Here, we investigate genomic signals on a second continent, South America, ask whether there is parallel multiple transects We first loci genome showing signatures climatic variation sampled transect accounting for neutral population structure. Consistent with previous results, most SNPs putatively regulatory regions. Genes that contained extreme outliers relate weight or immunity, fat, eye function, cardiovascular system. then compared these results analyses published data two America. While unique individual transects, found significant overlap among independently three transects. These diverse, functions relating cardiac circadian rhythm, others. also shifts allele frequency gradients. Finally, combining all several associated weight. Overall, our provide shared responses identify likely underlie recent house

Language: Английский

Citations

2