Genomic analysis of Strongyloides stercoralis and Strongyloides fuelleborni in Bangladesh

PLoS neglected tropical diseases, Journal Year: 2024, Volume and Issue: 18(9), P. e0012440 - e0012440

Published: Sept. 3, 2024

About 600 million people are estimated to be infected with Strongyloides stercoralis, the species that causes most of human strongyloidiasis cases. S. stercoralis can also infect non-human primates (NHPs), dogs and cats, rendering these animals putative sources for zoonotic infection. fuelleborni is normally found in old world NHPs but occasionally infects humans, mainly Africa. Dogs southeast Asia carry at least two types Strongyloides, only one which appears shared humans ("dog only" "human dog" types). For molecular taxonomic information, there a strong sampling bias towards east Australia.

Language: Английский

Genomic analysis of Strongyloides stercoralis and Strongyloides fuelleborni in Bangladesh

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 16, 2024

Abstract Background About 600 million people are estimated to be infected with Strongyloides stercoralis , the species that causes vast majority of human strongyloidiasis cases. S. can also infect non-human primates (NHPs), dogs and cats, rendering these animals putative sources for zoonotic infection. fuelleborni is normally found in old world NHPs but occasionally infects humans, mainly Africa. Dogs southeast Asia carry at least two types only one which appears shared humans (“dog only” “human dog” types). For molecular taxonomic information, there a strong sampling bias towards east Australia. Methodology/Principle findings We collected dog derived spp. hookworms from locations Bangladesh subjected them genomic analysis based on nuclear mitochondrial sequences. All were Necator americanus . Contrary earlier studies Asia, we noticed rather high incidence samples. Also this study, no indication genetic isolation Asian populations. However, worm sample genomically was “dog type worms had genomes genome type. Conclusions/Significance may play more prominent role as parasite certain places than previously thought. The introgression mitochondria haplotype into population suggests rare interbreeding between does occur exchange properties, example drug resistance, conceivable. Author Summary More nematode intestinal In different either or described. (normally old-world monkeys) hook worms, analyzed their genomes. major hookworm species. general believe infections extremely multiple such cases, suggesting plays important thought Asia. expected first time person This suggest occurs,

Language: Английский

The fourth-stage autoinfective larva of Strongyloides stercoralis : redescription and diagnostic implications

Journal of Clinical Microbiology, Journal Year: 2024, Volume and Issue: 63(1)

Published: Dec. 5, 2024

Human strongyloidiasis is often underdiagnosed or misdiagnosed, which can relate to a lack of knowledge recognition the importance particular developmental/larval stages Strongyloides stercoralis in making an accurate diagnosis using parasitological methods (a morphological approach features/characters). Here, we report identification S. autoinfective fourth-stage larvae (L4a) naturally infected humans, encountered two clinical cases Australia. These were identified sputum (Case 1) and bronchoalveolar lavage 2) specimens by direct wet-mount microscopy. The L4a be morphologically differentiated from third-stage its conical pointed tail relatively mature genital primordium with enlarged rudiment formation vulva within cuticle layers. This study emphasizes need consider these features stage for infection. A detailed description this given guide laboratory practitioners researchers differentiation unique but neglected life-cycle stercoralis.

Language: Английский