Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 203, P. 106740 - 106740
Published: Nov. 17, 2024
Language: Английский
Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2387 - 2387
Published: Oct. 18, 2024
Within the central nervous system, synaptic plasticity, fundamental to processes like learning and memory, is largely driven by activity-dependent changes in strength. This plasticity often manifests as long-term potentiation (LTP) depression (LTD), which are bidirectional modulations of efficacy. Strong epidemiological experimental evidence show that heart-brain axis could be severely compromised both neurological cardiovascular disorders. Particularly, disorders, such heart failure, hypertension, obesity, diabetes insulin resistance, arrhythmias, may lead cognitive impairment, a condition known cardiogenic dementia. Herein, we review available knowledge on molecular mechanisms dementia arise describe how LTP and/or LTD induction maintenance CA1 region hippocampus metabolic syndrome, arrhythmias. We also discuss emerging endothelial dysfunction contribute directly altering hippocampal impairing synaptically induced activation nitric oxide synthase. A better understanding CV disorders impact proper function synapses will shed novel light underpinnings dementia, thereby providing new perspective for more specific pharmacological treatments.
Language: Английский
Citations
6
Hippocampus, Journal Year: 2025, Volume and Issue: 35(2)
Published: Feb. 24, 2025
ABSTRACT The entorhinal cortex sends afferent information to the hippocampus by means of perforant path (PP). PP input dentate gyrus (DG) terminates in suprapyramidal (sDG) and infrapyramidal (iDG) blades. Different electrophysiological stimulation patterns can generate hippocampal synaptic plasticity. Whether frequency‐dependent plasticity differs sDG iDG is unclear. Here, we compared medial PP–DG responses freely behaving adult rats found that broadly frequency dependent, whereby long‐term depression (LTD, > 24 h) induced with at 1 Hz, short‐term (< 2 triggered 5 or 10 potentiation (LTP) increasing magnitudes 200 400 Hz stimulation, respectively. By contrast, although expresses STD following LTD weaker, LTP not significantly smaller magnitude than sDG. Furthermore, stimulus–response relationship suppressed These differences may arise from granule cell properties, complement NMDA receptors. Patch clamp recordings, vitro, revealed reduced firing frequencies response high currents, different action potential thresholds Assessment expression GluN subunits lower levels GluN1, GluN2A, GluN2B middle molecular layer Taken together, these data indicate less persistent responsive Effects be mediated weaker receptor neuronal versus characteristics explain reported experience‐dependent processing blades DG.
Language: Английский
Citations
0
Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: 252, P. 174026 - 174026
Published: April 29, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3131 - 3131
Published: March 28, 2025
Hydrogen sulfide (H2S) has emerged as a pivotal gaseous transmitter in the central nervous system, influencing synaptic plasticity, learning, and memory by modulating various molecular pathways. This review examines recent evidence regarding how H2S regulates NMDA receptor function neurotransmitter release neuronal circuits. By synthesizing findings from animal cellular models, we investigate impacts of enzymatic production exogenous on excitatory currents, long-term potentiation, intracellular calcium signaling. Data suggest that interacts directly with subunits, altering excitability. Simultaneously, promotes neurotransmitters such glutamate GABA, shaping dynamics plasticity. Furthermore, reports indicate disruptions metabolism contribute to cognitive impairments neurodegenerative disorders, underscoring potential therapeutic value targeting H2S-mediated Although precise mechanisms H2S-induced changes strength remain elusive, growing body positions significant regulator formation processes. calls for more rigorous exploration into underpinnings paving way novel pharmacological interventions dysfunction.
Language: Английский
Citations
0
Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 30, 2025
Maternal separation (MS) during early life can induce behaviors in adult animals that resemble those seen schizophrenia, manifesting cognitive deficits. These deficits may be indicative of oxidative stress linked to mitochondrial dysfunction. However, there is limited understanding the molecular mechanisms regulating mitochondria neural circuits govern impairment relevant and their impact on neuronal structure function. A 24-h MS rat model was utilized simulate features associated with schizophrenia. Schizophrenia-associated were assessed using open field test, pre-pulse inhibition, novel object recognition Barnes maze test. The levels proteins measured western blot analysis. Additionally, alterations morphology, reduced hippocampal spine density, impaired LTP hippocampus observed. Nicotinamide (NAM) supplementation, administration honokiol (HNK) (a SIRT3 activator), or overexpression could inhibit cellular Conversely, 3-TYP inhibitor) knocking down expression control rats led behavioral phenotype. Our results suggest a causal role for NAD+/SIRT3 axis modulating via effects synaptic plasticity. promising therapeutic target addressing dysfunctions, such as
Language: Английский
Citations
0
Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1906)
Published: June 10, 2024
We introduce and summarize reviews research papers by speakers at a discussion meeting on ‘Long-term potentiation: 50 years on’ held the Royal Society, London, 20–21 November 2023. The followed earlier meetings marking 30th 40th anniversaries of discovery long-term potentiation. These new contributions give an overview current controversies in vibrant branch neuroscience with important implications for our understanding neurobiological basis many forms learning memory wide spectrum neurological cognitive disorders. This article is part issue on'.
Language: Английский
Citations
1
Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 122(1)
Published: Dec. 30, 2024
The novelty, saliency, and valency of ongoing experiences potently influence the firing rate ventral tegmental area (VTA) locus coeruleus (LC). Associative experience, in turn, is recorded into memory by means hippocampal synaptic plasticity that regulated noradrenaline sourced from LC, dopamine, both VTA LC. Two persistent forms plasticity, long-term potentiation (LTP), depression (LTD) support encoding different kinds spatial experience. To what extent LC direction change therefore content stored experience not clear. Here, we report test-pulse activation Schaffer-collateral–CA1 synapses freely behaving male rats, conjunction with stimulation, results LTP (>24 h), whereas concomitant afferent stimulation LTD h). Effects are frequency-dependent (1 to 50 Hz) competitive: high-frequency (25 Hz), but low-frequency (5 optogenetic tyrosine hydroxylase-positive (TH+) neurons VTA, D1/D5R-dependent LTP, 5 Hz (but 1, or 25 TH+ D1/D5 β-AR-dependent. These suggest do work synergy, rather function a competing fashion drive information through plasticity. Our findings indicate transmitted likely play decisive role shaping storage nature learned
Language: Английский
Citations
1
Current topics in behavioral neurosciences, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 203, P. 106740 - 106740
Published: Nov. 17, 2024
Language: Английский
Citations
0