Recurring incursions and dissemination of novel Eurasian-origin H5Nx avian influenza viruses in Atlantic Canada DOI Creative Commons
Ishraq Rahman, Cassidy N. G. Erdelyan, Anthony V. Signore

et al.

Virus Evolution, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 1, 2024

Abstract Wild birds are important hosts of influenza A viruses (IAVs) and play an role in their ecology. The emergence the A/goose/Guangdong/1/1996 H5N1 (Gs/GD) lineage marked a shift IAV ecology, leading to recurrent outbreaks mortality wild from 2002 onwards. This has evolved diversified over time, with recent derivative being 2.3.4.4b sub-lineage, which caused significant events bird populations. An clade virus was transmitted into North America Eurasia 2021, first detection Newfoundland Labrador Atlantic Canada, this its reassortants then spread broadly throughout beyond. Following 2021 detection, there have been three additional known incursions Eurasian-origin strains second strain 2022 two H5N5 2023. In study, we document fifth incursion Canada that occurred 2023 by another strain. Quebec, infecting numerous species mammals. Genomic analysis revealed mammalian-adaptive mutations some detected (PB2-E627K PB2-D701N) hemagglutinin (HA) neuraminidase (NA) genes associated enhanced viral fitness avian transmission capabilities. Our findings indicate is continuing circulate wildlife, confirms American entry point for Eurasian IAVs. Continued surveillance genomic IAVs region crucial monitor evolution these assess potential risks wildlife public health.

Language: Английский

Reduced breeding success consistent with effects of high pathogenicity avian influenza (HPAI) on raptors in Scotland in 2022 DOI
Mark W. B. Wilson, Björn C. Beckmann,

Christine V. Wernham

et al.

Bird Study, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 28, 2025

Language: Английский

Citations

1
Unique Phenomenon of H5 Highly Pathogenic Avian Influenza Virus in China: Co-circulation of Clade 2.3.4.4b H5N1 and H5N6 results in diversity of H5 Virus DOI Creative Commons
Xuan Zhang, Yu-Jia Yang, Xinyu Han

et al.

Emerging Microbes & Infections, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Recently, Clade 2.3.4.4b H5N1 virus has been widely prevalent globally. Although no outbreaks of Avian Influenza have occurred in poultry China recently, H5 can still be isolated from wild birds, live markets and environment, indicating the ongoing co-circulation H5N6 viruses. In this study, phylogenetic analysis global viruses 20 laboratory-isolated strains revealed that Chinese since 2021 cluster into two distinct groups, G-I G-II. Bayesian phylodynamic reveals become an endemic China. contrast, G-II virus, with South as its main epicentre, disseminated surrounding countries, transmission more reliant on connections birds waterfowl. Reassortment indicates 2023, formed seven genotypes. The genome undergone changes compared to those previously Animal experiments shown exhibit significant lethality chickens. Additionally, certain capability systemic replication mice. It is noted HA genes derived demonstrate stronger virulence pathogenicity chickens mice Our study increased diversity viruses, making continuous surveillance essential.

Language: Английский

Citations

0
Emergence of highly pathogenic avian influenza viruses H5N1 and H5N5 in white-tailed eagles, 2021–2023 DOI
Cathrine Arnason Bøe, Eve Zeyl Fiskebeck, Malin R. Reiten

et al.

Journal of General Virology, Journal Year: 2024, Volume and Issue: 105(11)

Published: Nov. 1, 2024

Highly pathogenic avian influenza (HPAI) poses a substantial threat to several raptors. Between 2021 and 2023, HPAI viruses (HPAIVs) of the Goose/Guangdong lineage H5 clade 2.3.4.4b became widespread in wild birds Norway, H5N1 H5N5 were detected 31 white-tailed eagles (

Language: Английский

Citations

3
Recurring incursions and dissemination of novel Eurasian-origin H5Nx avian influenza viruses in Atlantic Canada DOI Creative Commons
Ishraq Rahman, Cassidy N. G. Erdelyan, Anthony V. Signore

et al.

Virus Evolution, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 1, 2024

Abstract Wild birds are important hosts of influenza A viruses (IAVs) and play an role in their ecology. The emergence the A/goose/Guangdong/1/1996 H5N1 (Gs/GD) lineage marked a shift IAV ecology, leading to recurrent outbreaks mortality wild from 2002 onwards. This has evolved diversified over time, with recent derivative being 2.3.4.4b sub-lineage, which caused significant events bird populations. An clade virus was transmitted into North America Eurasia 2021, first detection Newfoundland Labrador Atlantic Canada, this its reassortants then spread broadly throughout beyond. Following 2021 detection, there have been three additional known incursions Eurasian-origin strains second strain 2022 two H5N5 2023. In study, we document fifth incursion Canada that occurred 2023 by another strain. Quebec, infecting numerous species mammals. Genomic analysis revealed mammalian-adaptive mutations some detected (PB2-E627K PB2-D701N) hemagglutinin (HA) neuraminidase (NA) genes associated enhanced viral fitness avian transmission capabilities. Our findings indicate is continuing circulate wildlife, confirms American entry point for Eurasian IAVs. Continued surveillance genomic IAVs region crucial monitor evolution these assess potential risks wildlife public health.

Language: Английский

Citations

2