Prolactin Role in COVID-19 and Its Association with the Underlying Inflammatory Response DOI Open Access

Eleni Polyzou,

Georgios Schinas, Panagiotis Bountouris

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11905 - 11905

Published: Nov. 6, 2024

The COVID-19 pandemic has prompted interest in identifying reliable biomarkers to predict disease severity and guide clinical decisions. Prolactin (PRL), a hormone traditionally associated with lactation, gained attention for its role immune modulation. This study aimed assess PRL as biomarker COVID-19. A prospective cohort of 142 patients moderate severe COVID-19, defined WHO-CPS 5 or 6, was recruited from the University General Hospital Patras. Baseline levels were measured using an electrochemiluminescence immunoassay, serum cytokines, including IL-1β, IL-6, IL-8, IL-10, IL-12p70, TNF-α, quantified through flow cytometry. Clinical outcomes, mortality need invasive mechanical ventilation (IMV), recorded. Results indicated that significantly higher female (12.95 ng/mL vs. 9.40 ng/mL,

Language: Английский

Optimizing Clinical Management of COVID-19: A Predictive Model for Unvaccinated Patients Admitted to ICU DOI Creative Commons

Ahmed Farhan,

Khouloud Ayed,

Sara Zayati

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 230 - 230

Published: Feb. 27, 2025

This study investigates the impact of immunological and clinical factors on COVID-19 outcomes among unvaccinated individuals. A cohort 42 patients admitted to an intensive care unit was analyzed, focusing age, comorbidities, inflammatory cytokines (IL-6, TNF-α), anti-SARS-CoV-2 spike protein antibody levels (IgG) assess their influence hospital stay duration, recovery time, complications, mortality rates. The findings revealed that advanced cardiovascular disease, elevated pro-inflammatory significantly heightened risks severe complications mortality. Conversely, low IgG correlated with prolonged stays slower recovery. Multivariate analysis identified high IL-6 TNF-α as strong predictors adverse outcomes. research emphasizes need for early monitoring targeted management strategies mitigate COVID-19, especially high-risk populations.

Language: Английский

Citations

0
Prolactin Role in COVID-19 and Its Association with the Underlying Inflammatory Response DOI Open Access

Eleni Polyzou,

Georgios Schinas, Panagiotis Bountouris

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11905 - 11905

Published: Nov. 6, 2024

The COVID-19 pandemic has prompted interest in identifying reliable biomarkers to predict disease severity and guide clinical decisions. Prolactin (PRL), a hormone traditionally associated with lactation, gained attention for its role immune modulation. This study aimed assess PRL as biomarker COVID-19. A prospective cohort of 142 patients moderate severe COVID-19, defined WHO-CPS 5 or 6, was recruited from the University General Hospital Patras. Baseline levels were measured using an electrochemiluminescence immunoassay, serum cytokines, including IL-1β, IL-6, IL-8, IL-10, IL-12p70, TNF-α, quantified through flow cytometry. Clinical outcomes, mortality need invasive mechanical ventilation (IMV), recorded. Results indicated that significantly higher female (12.95 ng/mL vs. 9.40 ng/mL,

Language: Английский

Citations

0