A Decade-Long Review of the Virulence, Resistance, and Epidemiological Risks of Klebsiella pneumoniae in ICUs DOI Creative Commons
Tao-An Chen,

Ya-Ting Chuang,

Chieh-Hui Lin

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2548 - 2548

Published: Dec. 11, 2024

Klebsiella pneumoniae, a major opportunistic pathogen, causes severe infections in both community and healthcare settings, especially intensive care units (ICUs), where multidrug-resistant (MDR) strains, such as carbapenem-resistant K. pneumoniae (CRKP), pose significant treatment challenges. The rise hypervirulent (hvKP) with enhanced virulence factors complicates management further. ST11 clone, prevalent China, exhibits resistance traits, contributing to hospital outbreaks. ICU patients, particularly those comorbidities or prior antibiotic exposure, are at higher risk. Treatment is complicated by limited options the increasing prevalence of polymicrobial infections, which involve resistant pathogens like Pseudomonas aeruginosa Acinetobacter baumannii. Combination therapies offer some promise, but mortality rates remain high, last-resort antibiotics growing. Infection control measures personalized plans critical, alongside urgent need for vaccine development combat rising threat vulnerable populations. Effective requires improved diagnostic tools, antimicrobial stewardship, innovative strategies reduce burden this resource-limited settings. This review aims provide comprehensive analysis virulence, resistance, epidemiological risks ICUs over past decade, highlighting ongoing challenges continued efforts growing threat.

Language: Английский

A Decade-Long Review of the Virulence, Resistance, and Epidemiological Risks of Klebsiella pneumoniae in ICUs DOI Creative Commons
Tao-An Chen,

Ya-Ting Chuang,

Chieh-Hui Lin

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2548 - 2548

Published: Dec. 11, 2024

Klebsiella pneumoniae, a major opportunistic pathogen, causes severe infections in both community and healthcare settings, especially intensive care units (ICUs), where multidrug-resistant (MDR) strains, such as carbapenem-resistant K. pneumoniae (CRKP), pose significant treatment challenges. The rise hypervirulent (hvKP) with enhanced virulence factors complicates management further. ST11 clone, prevalent China, exhibits resistance traits, contributing to hospital outbreaks. ICU patients, particularly those comorbidities or prior antibiotic exposure, are at higher risk. Treatment is complicated by limited options the increasing prevalence of polymicrobial infections, which involve resistant pathogens like Pseudomonas aeruginosa Acinetobacter baumannii. Combination therapies offer some promise, but mortality rates remain high, last-resort antibiotics growing. Infection control measures personalized plans critical, alongside urgent need for vaccine development combat rising threat vulnerable populations. Effective requires improved diagnostic tools, antimicrobial stewardship, innovative strategies reduce burden this resource-limited settings. This review aims provide comprehensive analysis virulence, resistance, epidemiological risks ICUs over past decade, highlighting ongoing challenges continued efforts growing threat.

Language: Английский

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