Comparative Genomic Profiles of Salmonella Typhimurium and Salmonella Dublin Bovine Isolates from the U.S. Indicate Possible Factors Associated with the Host Adaptation of Salmonella Dublin in the Region DOI Creative Commons
Kingsley E. Bentum,

Emmanuel Kuufire,

Rejoice Nyarku

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 886 - 886

Published: April 12, 2025

Salmonella Dublin (S. Dublin) and Typhimurium Typhimurium) are commonly linked to bovine salmonellosis. S. is, however, considered a bovine-adapted serovar for primarily infecting thriving in cattle. Using (a generalist serovar) as benchmark, this study investigates genomic factors contributing Dublin’s adaptation cattle hosts the U.S. A total of 1337 787 whole-genome sequences from sources were analyzed with CARD (version 4.0.0), ARG-NOTT 6), AMRfinderPlus 4.0.3) antimicrobial resistance (AMR) genes; VFDB virulence AMRFinderPlus stress Plasmidfinder plasmids. Existing clonal groups among isolates two serovars also investigated using Hierarchical Clustering Core Genome Multi-Locus Sequence Typing (HierCC-cgMLST) model. The results revealed minimal variation isolates. Comparatively, IncX1 plasmid was somewhat exclusively identified each carried an average four plasmids (p-value < 0.05). Furthermore, exhibited higher prevalence AMR genes against key antimicrobials, including aminoglycosides, beta-lactams, tetracyclines, sulfonamides, used production. Additionally, Type VI secretion system tssJKLM hcp2/tssD2, essential colonization, found over 50% these possessing that confer heavy metal stressors, like mercury. These findings suggest is supported by conserved genetic makeup enriched genes, factors, stress-related enabling it colonize persist gut.

Language: Английский

Comparative Genomic Profiles of Salmonella Typhimurium and Salmonella Dublin Bovine Isolates from the U.S. Indicate Possible Factors Associated with the Host Adaptation of Salmonella Dublin in the Region DOI Creative Commons
Kingsley E. Bentum,

Emmanuel Kuufire,

Rejoice Nyarku

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 886 - 886

Published: April 12, 2025

Salmonella Dublin (S. Dublin) and Typhimurium Typhimurium) are commonly linked to bovine salmonellosis. S. is, however, considered a bovine-adapted serovar for primarily infecting thriving in cattle. Using (a generalist serovar) as benchmark, this study investigates genomic factors contributing Dublin’s adaptation cattle hosts the U.S. A total of 1337 787 whole-genome sequences from sources were analyzed with CARD (version 4.0.0), ARG-NOTT 6), AMRfinderPlus 4.0.3) antimicrobial resistance (AMR) genes; VFDB virulence AMRFinderPlus stress Plasmidfinder plasmids. Existing clonal groups among isolates two serovars also investigated using Hierarchical Clustering Core Genome Multi-Locus Sequence Typing (HierCC-cgMLST) model. The results revealed minimal variation isolates. Comparatively, IncX1 plasmid was somewhat exclusively identified each carried an average four plasmids (p-value < 0.05). Furthermore, exhibited higher prevalence AMR genes against key antimicrobials, including aminoglycosides, beta-lactams, tetracyclines, sulfonamides, used production. Additionally, Type VI secretion system tssJKLM hcp2/tssD2, essential colonization, found over 50% these possessing that confer heavy metal stressors, like mercury. These findings suggest is supported by conserved genetic makeup enriched genes, factors, stress-related enabling it colonize persist gut.

Language: Английский

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