Genetically Encoded Synthetic Beta Cells for Insulin Biosynthesis and Release under Hyperglycemic Conditions DOI Creative Commons
Jian Liu, Jueyi Xue, Lu Fu

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(18)

Published: Jan. 20, 2022

Abstract Advances in artificial/synthetic cells have drawn a new era of nanobiotechnology, which shown broad prospects biomedical applications. The rational nanoengineering synthetic that can closely substitute the systematic biological functions is next grand challenge. Here, genetically encoded beta cell, sense hyperglycemic conditions to initiate programmed biosynthesis and secretion insulin reported. By encapsulating different metal–organic framework‐based artificial organelles with distinctive bifunctionalities, cell undergo programmed, sequential subcellular events, including glucose sensing, initiation gene transcription translation, finally excretion functional insulin, under conditions. Glucose uptake assay suggests produced by successfully promote into mammalian cells. construction higher‐order cluster ligand‐mediated super‐assembly further demonstrated. Such robust smart system mimics cellular activities response levels promising for improving clinical outcomes diabetes treatment.

Language: Английский

Genetically Encoded Synthetic Beta Cells for Insulin Biosynthesis and Release under Hyperglycemic Conditions DOI Creative Commons
Jian Liu, Jueyi Xue, Lu Fu

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(18)

Published: Jan. 20, 2022

Abstract Advances in artificial/synthetic cells have drawn a new era of nanobiotechnology, which shown broad prospects biomedical applications. The rational nanoengineering synthetic that can closely substitute the systematic biological functions is next grand challenge. Here, genetically encoded beta cell, sense hyperglycemic conditions to initiate programmed biosynthesis and secretion insulin reported. By encapsulating different metal–organic framework‐based artificial organelles with distinctive bifunctionalities, cell undergo programmed, sequential subcellular events, including glucose sensing, initiation gene transcription translation, finally excretion functional insulin, under conditions. Glucose uptake assay suggests produced by successfully promote into mammalian cells. construction higher‐order cluster ligand‐mediated super‐assembly further demonstrated. Such robust smart system mimics cellular activities response levels promising for improving clinical outcomes diabetes treatment.

Language: Английский

Citations

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