A connectome of theDrosophilacentral complex reveals network motifs suitable for flexible navigation and context-dependent action selection DOI Creative Commons
Brad K. Hulse, Hannah Haberkern, Romain Franconville

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: Dec. 9, 2020

ABSTRACT Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron-microscopy-based connectome of Drosophila CX, including all its neurons circuits at synaptic resolution. identified new CX neuron types, novel sensory motor pathways, network motifs that likely extract fly’s head-direction, maintain it with attractor dynamics, combine other sensorimotor information perform vector-based navigational computations. also numerous pathways may facilitate selection CX-driven behavioral patterns by context internal state. The provides comprehensive blueprint necessary for detailed understanding underlying flexible navigation, state-dependent action selection.

Language: Английский

Comparative connectomics of the descending and ascending neurons of theDrosophilanervous system: stereotypy and sexual dimorphism DOI Creative Commons
Tomke Stürner, P. D. Brooks, Laia Serratosa Capdevila

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical information bottleneck connecting brain ventral cord (VNC, spinal analogue) comprises diverse populations descending (DN), ascending (AN) sensory neurons, are crucial sensorimotor signalling control. Integrating three separate EM datasets, we now provide complete connectomic description neurons female system

Language: Английский

Citations

12
Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome DOI Open Access
Han SJ Cheong, Katharina Eichler, Tomke Stürner

et al.

Published: March 18, 2024

In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed connectome Male Adult Nerve Cord (MANC, Takemura et al., 2023), including cell type developmental lineage annotation (Marin which provides complete VNC connectivity at synaptic resolution. Here, present first look organization networks connecting DNs based on this new information. We proofread curated all ensure accuracy reliability, then systematically matched DN axon terminals MN dendrites with light microscopy data link their morphology inputs or muscle targets. report both broad organizational patterns entire network fine-scale analysis selected interest. discover direct DN-MN connections infrequent identify communities intrinsic linked control different systems, putative for walking, dorsal flight steering power generation, intermediate lower tectulum coordinated action wings legs. Our generates hypotheses future functional experiments and, together MANC connectome, empowers others investigate richer mechanistic detail.

Language: Английский

Citations

9
Auditory activity is diverse and widespread throughout the central brain of Drosophila DOI
Diego A. Pacheco, Stephan Y. Thiberge, Eftychios A. Pnevmatikakis

et al.

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 24(1), P. 93 - 104

Published: Nov. 23, 2020

Language: Английский

Citations

61
Transsynaptic mapping of Drosophila mushroom body output neurons DOI Creative Commons
Kristin M. Scaplen, Mustafa Talay, John D. Fisher

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Feb. 10, 2021

The mushroom body (MB) is a well-characterized associative memory structure within the

Language: Английский

Citations

53
A connectome of theDrosophilacentral complex reveals network motifs suitable for flexible navigation and context-dependent action selection DOI Creative Commons
Brad K. Hulse, Hannah Haberkern, Romain Franconville

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: Dec. 9, 2020

ABSTRACT Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which experimentally challenging study. In insects, circuit dynamics a region called the central complex (CX) enable directed locomotion, sleep, and context- experience-dependent spatial navigation. We describe first complete electron-microscopy-based connectome of Drosophila CX, including all its neurons circuits at synaptic resolution. identified new CX neuron types, novel sensory motor pathways, network motifs that likely extract fly’s head-direction, maintain it with attractor dynamics, combine other sensorimotor information perform vector-based navigational computations. also numerous pathways may facilitate selection CX-driven behavioral patterns by context internal state. The provides comprehensive blueprint necessary for detailed understanding underlying flexible navigation, state-dependent action selection.

Language: Английский

Citations

50