How social play experience shapes development of higher brain function DOI Open Access
Ate Bijlsma

Published: Sept. 25, 2023

Social behavior is of great importance in human and animal life encompasses a wide range sophisticated social interactions. play believed to promote the physical, social, cognitive emotional development animals. Moreover, it enables animals living groups practice their complex repertoire behaviors simplified form. In this thesis, we test hypothesis that essential for network prefrontal cortex (PFC), an important brain region behavioral flexibility adulthood. To this, rats are deprived behavior. Our research revealed interaction between experience specific developmental trajectories subregions on inhibitory, but not excitatory, signals. parallel experiments, adult playdeprived used more strategy PFC-dependent task. We further show exposure risks during influences performance tasks anxiety-like adulthood inhibitory signals mPFC. addition, our results indicated interactions risky deprivation were limited, suggesting peer ability take independently influence PFC function. summary, thesis contributes better understanding at molecular level. It becomes clear different types parts

Language: Английский

Cortical Representation of Touch in Silico DOI Creative Commons
Chao Huang, Fleur Zeldenrust, Tansu Celikel

et al.

Neuroinformatics, Journal Year: 2022, Volume and Issue: 20(4), P. 1013 - 1039

Published: April 29, 2022

Abstract With its six layers and ~ 12,000 neurons, a cortical column is complex network whose function plausibly greater than the sum of constituents’. Functional characterization components will require going beyond brute-force modulation neural activity small group neurons. Here we introduce an open-source, biologically inspired, computationally efficient model somatosensory cortex’s granular supragranular after reconstructing barrel cortex in soma resolution. Comparisons to empirical observations showed that silico replicates known properties touch representations whisker deprivation-induced changes synaptic strength induced vivo. Simulations show history membrane potential acts as spatial filter determines presynaptic population neurons contributing post-synaptic action potential; this filtering might be critical for integration top-down bottom-up information.

Language: Английский

Citations

12
Information transfer and recovery for the sense of touch DOI Creative Commons
Chao Huang, Bernhard Englitz,

Andrey Reznik

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: Dec. 9, 2020

Abstract Transformation of postsynaptic potentials (PSPs) into action (APs) is the rate-limiting step communication in neural networks. The efficiency this intracellular information transfer also powerfully shapes stimulus representations sensory cortices. Using whole-cell recordings and information-theoretic measures, we show herein that somatic PSPs accurately represent location on a trial-by-trial basis single neurons even 4 synapses away from periphery whisker system. This largely lost during AP generation but can be rapidly (<20 ms) recovered using complementary local populations cell-type-specific manner. These results as transferred one locus to another, circuits reconstruct with high fidelity so faithfully periphery, only their PSPs, resulting lossless processing for sense touch primary somatosensory cortex.

Language: Английский

Citations

6
A whole-cell recording database of neuromodulatory action in the adult neocortex DOI Creative Commons

Xuan Yan,

Niccolò Calcini,

Payam Safavi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 13, 2022

Background The recent release of two large intracellular electrophysiological databases now allows high-dimensional systematic analysis mechanisms information processing in the neocortex. Here, to complement these efforts, we introduce a freely and publicly available database that provides comparative insight into role various neuromodulatory transmitters controlling neural processing. Findings A vitro whole-cell patch-clamp recordings from primary somatosensory motor cortices (layers 2/3) adult mice (2-15 months old) both sexes is introduced. total 464 current-clamp experiments identified excitatory inhibitory neurons are provided. Experiments include with (i) Step-and-Hold protocol during which current was transiently held at 10 steps, gradually increasing amplitude, (ii) “Frozen Noise” injections model amplitude time-varying nature synaptic inputs neuron biological networks. All follow within across drug design includes vehicle control modulation one following targets same neuron: dopamine its receptors D1R, D2R, serotonin 5HT1f receptor, norepinephrine Alpha1, acetylcholine M1 receptors. Conclusions This dataset first provide selected neuromodulators cellular excitability. data will help mechanistically address how bottom-up can be modulated, providing reference for studying coding characteristics revealing contribution neuromodulation

Language: Английский

Citations

4
Cortical representation of touch in silico DOI Creative Commons
Chao Huang, Fleur Zeldenrust, Tansu Celikel

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: Nov. 7, 2020

Abstract With its six layers and ~12000 neurons, a cortical column is complex network whose function plausibly greater than the sum of constituents’. Functional characterization components will require going beyond brute-force modulation neural activity small group neurons. Here we introduce an open-source, biologically inspired, computationally efficient model somatosensory cortex’s granular supragranular after reconstructing barrel cortex in soma resolution. Comparisons to empirical observations showed that silico replicates known properties touch representations whisker deprivation-induced changes synaptic strength induced vivo . Simulations show history membrane potential acts as spatial filter determines presynaptic population neurons contributing post-synaptic action potential; this filtering might be critical for integration top-down bottom-up information.

Language: Английский

Citations

3
NETSCOPE: Information-Theory based Network Discovery and Analysis DOI Creative Commons

Tido Bergmans,

Tousif Jamal,

Tansu Celikel

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: April 18, 2022

Abstract Molecular, cellular, structural, and functional networks in the brain each represent different levels of organization complexity. These are interconnected, their interactions underlie brain’s abilities to process information, regulate bodily functions, mediate behavior. While understanding emergence higher-level (structural functional) from lower-level (molecular cellular) ones is crucial, a universal analytical method applicable all network types has been lacking. Here we introduce an open-source toolbox (NETSCOPE) that identifies weighted architectures using mutual information (MI) variation (VI). We demonstrate accuracy resulting synthetic data by recreating five molecular S. cerevisiae. finally deploy NETSCOPE identify cell type specific transcriptional reconstruct brain-wide neural encode touch mouse brain. The code made available Python, Google Colab, Jupyter Notebook, MATLAB, Octave. Beyond its core functionality, this discovery holds potential for broader applications, including development bioinspired sparse artificial networks.

Language: Английский

Citations

1
How social play experience shapes development of higher brain function DOI Open Access
Ate Bijlsma

Published: Sept. 25, 2023

Social behavior is of great importance in human and animal life encompasses a wide range sophisticated social interactions. play believed to promote the physical, social, cognitive emotional development animals. Moreover, it enables animals living groups practice their complex repertoire behaviors simplified form. In this thesis, we test hypothesis that essential for network prefrontal cortex (PFC), an important brain region behavioral flexibility adulthood. To this, rats are deprived behavior. Our research revealed interaction between experience specific developmental trajectories subregions on inhibitory, but not excitatory, signals. parallel experiments, adult playdeprived used more strategy PFC-dependent task. We further show exposure risks during influences performance tasks anxiety-like adulthood inhibitory signals mPFC. addition, our results indicated interactions risky deprivation were limited, suggesting peer ability take independently influence PFC function. summary, thesis contributes better understanding at molecular level. It becomes clear different types parts

Language: Английский

Citations

0