The Regulation Effect of α7nAChRs and M1AChRs on Inflammation and Immunity in Sepsis DOI Creative Commons
Song Hu,

Wang Yundong,

Hongbing Li

et al.

Mediators of Inflammation, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 10

Published: Nov. 3, 2021

The inflammatory storm in the early stage and immunosuppression late are responsible for high mortality rates multiple organ dysfunction sepsis. In recent years, studies have found that body’s cholinergic system can spontaneously dynamically regulate inflammation immunity sepsis according to needs of body. Firstly, vagus nerve senses regulates local or systemic by means Cholinergic Anti-inflammatory Pathway (CAP) activation α7-nicotinic acetylcholine receptors (α7nAChRs); thus, α7nAChRs play important roles central nervous (CNS) modulate peripheral inflammation; secondly, muscarinic 1 (M1AChRs) forebrain affect neurons Medullary Visceral Zone (MVZ), core CAP, immunity. Based on critical role these two receptor systems sepsis, it is necessary collect analyze related findings years provide ideas further research clinical applications. By consulting literature, we draw some conclusions: MVZ primary center It coordinates not only sympathetic but also autonomic neuroendocrine immunity; widely expressed immune cells, neurons, muscle cells; suppress expression represents acute chronic state a certain extent; M1AChRs mainly advanced centers brain neuroinflammation MVZ, hypothalamus, induced leads their dysfunctions underlies regulatory Correcting adjusting function may be key strategies treatment future.

Language: Английский

The Regulation Effect of α7nAChRs and M1AChRs on Inflammation and Immunity in Sepsis DOI Creative Commons
Song Hu,

Wang Yundong,

Hongbing Li

et al.

Mediators of Inflammation, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 10

Published: Nov. 3, 2021

The inflammatory storm in the early stage and immunosuppression late are responsible for high mortality rates multiple organ dysfunction sepsis. In recent years, studies have found that body’s cholinergic system can spontaneously dynamically regulate inflammation immunity sepsis according to needs of body. Firstly, vagus nerve senses regulates local or systemic by means Cholinergic Anti-inflammatory Pathway (CAP) activation α7-nicotinic acetylcholine receptors (α7nAChRs); thus, α7nAChRs play important roles central nervous (CNS) modulate peripheral inflammation; secondly, muscarinic 1 (M1AChRs) forebrain affect neurons Medullary Visceral Zone (MVZ), core CAP, immunity. Based on critical role these two receptor systems sepsis, it is necessary collect analyze related findings years provide ideas further research clinical applications. By consulting literature, we draw some conclusions: MVZ primary center It coordinates not only sympathetic but also autonomic neuroendocrine immunity; widely expressed immune cells, neurons, muscle cells; suppress expression represents acute chronic state a certain extent; M1AChRs mainly advanced centers brain neuroinflammation MVZ, hypothalamus, induced leads their dysfunctions underlies regulatory Correcting adjusting function may be key strategies treatment future.

Language: Английский

Citations

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