Long-Range GABAergic Projections of Cortical Origin in Brain Function DOI Creative Commons

Jocelyn Urrutia-Piñones,

Camila Morales-Moraga,

Nicole Sanguinetti-González

et al.

Frontiers in Systems Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: March 22, 2022

The study of long-range GABAergic projections has traditionally been focused on those with subcortical origin. In the last few years, cortical neurons have shown to not only mediate local inhibition, but also extend axons remote and areas. this review, we delineate different types (LRGNs) that reported arise from hippocampus neocortex, paying attention anatomical functional circuits they form understand their role in behavior. Although LRGNs are similar interneuron counterparts, comprise distinct populations show specific patterns cortico-cortical cortico-fugal connectivity. Functionally, likely induce timed disinhibition target regions synchronize network activity. Thus, emerging as a new element output, acting concert excitatory shape brain function health disease.

Language: Английский

Long-Range GABAergic Projections of Cortical Origin in Brain Function DOI Creative Commons

Jocelyn Urrutia-Piñones,

Camila Morales-Moraga,

Nicole Sanguinetti-González

et al.

Frontiers in Systems Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: March 22, 2022

The study of long-range GABAergic projections has traditionally been focused on those with subcortical origin. In the last few years, cortical neurons have shown to not only mediate local inhibition, but also extend axons remote and areas. this review, we delineate different types (LRGNs) that reported arise from hippocampus neocortex, paying attention anatomical functional circuits they form understand their role in behavior. Although LRGNs are similar interneuron counterparts, comprise distinct populations show specific patterns cortico-cortical cortico-fugal connectivity. Functionally, likely induce timed disinhibition target regions synchronize network activity. Thus, emerging as a new element output, acting concert excitatory shape brain function health disease.

Language: Английский

Citations

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