Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 15, 2024

Abstract Androgenetic alopecia is a highly heritable trait. However, much of our understanding about the genetics male pattern baldness comes from individuals European descent. Here, we examined novel dataset comprising 2,136 men Ghana, Nigeria, Senegal, and South Africa that were genotyped using custom array. We first tested how genetic predictions generalize Europe to Africa, finding polygenic scores GWAS yielded AUC statistics ranged 0.513 0.546, indicating in African populations performed notably worse than populations. Subsequently, conducted androgenetic alopecia, focusing on self-reported patterns at age 45. After correcting for present age, population structure, study site, identified 266 moderately significant associations, 51 which independent (p-value < 10 -5 , r 2 0.2). Most associations autosomal, X chromosomes does not appear have large impact men. Finally, evolutionary causes continental differences architecture. Although Neanderthal alleles previously been associated with skin hair phenotypes, did find evidence European-ascertained hits enriched signatures ancient introgression. loci are evolving neutrally. multiple baldness-associated SNPs near EDA2R AR genes allele frequency between continents. Collectively, findings illustrate history contributes limited portability across ancestries.

Language: Английский

Genetics and precision health: the ecological fallacy and artificial intelligence solutions

BioData Mining, Journal Year: 2023, Volume and Issue: 16(1)

Published: March 13, 2023

Language: Английский