Restoring Vascular Smooth Muscle Cell Mitochondrial Function Attenuates Abdominal Aortic Aneurysm in Mice DOI
Yao-Zhong Liu, Minzhi Yu, Huilun Wang

et al.

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex vascular pathology without pharmaceutical interventions. This study aimed to evaluate whether restoring smooth muscle cell (VSMC) mitochondrial function could prevent AAA development. METHODS: Ang II (angiotensin II)–induced was established in Ldlr -deficient mice, and the gene expression profiles abdominal tissues exhibiting varying degrees of severity were analyzed. Synthetic high-density lipoprotein (sHDL) formulated with Apoa1 mimetic peptide phospholipids evaluated for protective effects on VSMC mitochondria. The therapeutic efficacy sHDL further investigated II–infusion PPE (porcine pancreatic elastase)-induced models. RESULTS: damage intensified gradually during development, which confirmed distinct animal models human tissues. accumulated aneurysmatic lesions restored DNA levels genes related oxidative phosphorylation following infusion. In mouse primary VSMCs, maintained homeostasis by suppressing upregulation DRP1 (dynamin-related protein 1), involved fission, reducing generation reactive oxygen species, preventing loss membrane potential, preserving respiratory capacity. Administration decreased II–induced incidence (control versus treatment, 76% 40%; P <0.05) maximum diameters. validated model, reductions observed diameters loss. Post-Ang infusion, administration improved suppressed growth Apoe-deficient mice. Human characterized dysfunction, liver-derived HDL (high-density lipoprotein) components play pivotal role regulating CONCLUSIONS: factor development AAA. utilization nanoparticles represents promising novel approach AAA, at function.

Language: Английский

Restoring Vascular Smooth Muscle Cell Mitochondrial Function Attenuates Abdominal Aortic Aneurysm in Mice DOI
Yao-Zhong Liu, Minzhi Yu, Huilun Wang

et al.

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

BACKGROUND: Abdominal aortic aneurysm (AAA) is a complex vascular pathology without pharmaceutical interventions. This study aimed to evaluate whether restoring smooth muscle cell (VSMC) mitochondrial function could prevent AAA development. METHODS: Ang II (angiotensin II)–induced was established in Ldlr -deficient mice, and the gene expression profiles abdominal tissues exhibiting varying degrees of severity were analyzed. Synthetic high-density lipoprotein (sHDL) formulated with Apoa1 mimetic peptide phospholipids evaluated for protective effects on VSMC mitochondria. The therapeutic efficacy sHDL further investigated II–infusion PPE (porcine pancreatic elastase)-induced models. RESULTS: damage intensified gradually during development, which confirmed distinct animal models human tissues. accumulated aneurysmatic lesions restored DNA levels genes related oxidative phosphorylation following infusion. In mouse primary VSMCs, maintained homeostasis by suppressing upregulation DRP1 (dynamin-related protein 1), involved fission, reducing generation reactive oxygen species, preventing loss membrane potential, preserving respiratory capacity. Administration decreased II–induced incidence (control versus treatment, 76% 40%; P <0.05) maximum diameters. validated model, reductions observed diameters loss. Post-Ang infusion, administration improved suppressed growth Apoe-deficient mice. Human characterized dysfunction, liver-derived HDL (high-density lipoprotein) components play pivotal role regulating CONCLUSIONS: factor development AAA. utilization nanoparticles represents promising novel approach AAA, at function.

Language: Английский

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