Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults DOI Creative Commons
Sarah L. Silverberg, Hennady P. Shulha,

Brynn McMillan

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 16, 2023

ABSTRACT BACKGROUND Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity and risk factors SARS-CoV-2 among children young adults during pandemic in British Columbia (BC). METHODS conducted two cross-sectional serosurveys: phase 1 enrolled <25 years between November 2020-May 2021 2 <10 June 2021-May 2022 BC. Participants completed electronic surveys self-collected finger-prick dried blood spot (DBS) samples. Samples were tested for immunoglobulin G antibodies against ancestral spike protein (S). Descriptive statistics from survey data reported multivariable analyses evaluate associated with seropositivity. RESULTS A total 2864 participants enrolled, 95/2167 (4.4%) S-seropositive across all ages, 61/697 (8.8%) unvaccinated aged under ten 2. Overall, South Asian had a higher than other ethnicities (13.5% vs. 5.2%). Of 156 seropositive both phases, 120 no prior positive test. Young infants highest rates (7.0% 7.2% respectively 3.0-5.6% age groups). CONCLUSION was low May 2022, Asians disproportionately infected. This work demonstrates need improved diagnostics reporting strategies that account differences dynamics acceptability mechanisms.

Language: Английский

COVID-19 endgame: From pandemic to endemic? Vaccination, reopening and evolution in low- and high-vaccinated populations DOI
Elisha B. Are,

Yexuan Song,

Jessica E. Stockdale

et al.

Journal of Theoretical Biology, Journal Year: 2022, Volume and Issue: 559, P. 111368 - 111368

Published: Nov. 24, 2022

Language: Английский

Citations

50
Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults DOI Creative Commons
Sarah L. Silverberg, Hennady P. Shulha,

Brynn McMillan

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 15, 2024

Abstract Background and objectives Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity risk factors SARS-CoV-2 among children young adults during pandemic in British Columbia (BC). Methods conducted two cross-sectional serosurveys: phase 1 enrolled < 25 years between November 2020-May 2021 2 10 June 2021-May 2022 BC. Participants completed electronic surveys self-collected finger-prick dried blood spot (DBS) samples. Samples were tested for immunoglobulin G antibodies against ancestral spike protein (S). Descriptive statistics from survey data reported multivariable analyses evaluate associated with seropositivity. Results A total 2864 participants enrolled, 95/2167 (4.4%) S-seropositive across all ages, 61/697 (8.8%) unvaccinated aged under ten 2. Overall, South Asian had a higher than other ethnicities (13.5% vs. 5.2%). Of 156 seropositive both phases, 120 no prior positive test. Young infants highest rates (7.0% 7.2% respectively 3.0-5.6% age groups). Conclusions was low May 2022, Asians disproportionately infected. This work demonstrates need improved diagnostics reporting strategies that account differences dynamics acceptability mechanisms.

Language: Английский

Citations

1
Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults DOI Creative Commons
Sarah L. Silverberg, Hennady P. Shulha,

Brynn McMillan

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 16, 2023

ABSTRACT BACKGROUND Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity and risk factors SARS-CoV-2 among children young adults during pandemic in British Columbia (BC). METHODS conducted two cross-sectional serosurveys: phase 1 enrolled <25 years between November 2020-May 2021 2 <10 June 2021-May 2022 BC. Participants completed electronic surveys self-collected finger-prick dried blood spot (DBS) samples. Samples were tested for immunoglobulin G antibodies against ancestral spike protein (S). Descriptive statistics from survey data reported multivariable analyses evaluate associated with seropositivity. RESULTS A total 2864 participants enrolled, 95/2167 (4.4%) S-seropositive across all ages, 61/697 (8.8%) unvaccinated aged under ten 2. Overall, South Asian had a higher than other ethnicities (13.5% vs. 5.2%). Of 156 seropositive both phases, 120 no prior positive test. Young infants highest rates (7.0% 7.2% respectively 3.0-5.6% age groups). CONCLUSION was low May 2022, Asians disproportionately infected. This work demonstrates need improved diagnostics reporting strategies that account differences dynamics acceptability mechanisms.

Language: Английский

Citations

0