Mathematical modelling of haemorrhagic transformation in the human brain DOI Creative Commons
Xi Chen, Jiayu Wang,

Katinka R. van Kranendonk

et al.

Applied Mathematical Modelling, Journal Year: 2023, Volume and Issue: 121, P. 96 - 110

Published: April 28, 2023

Haemorrhagic transformation (HT) is one of the most common complications after ischaemic stroke. HT can be result stroke progression or a complication reperfusion treatment for The aim this study to apply previously proposed mathematical model within computational whole brain determine factors that affect severity HT. In addition, these simulations are directly compared with neuroimaging data. MR CLEANNO IV trial assessed effect endovascular therapy (EVT) alone intravenous alteplase (IVT) followed by EVT patients acute due anterior circulation large vessel occlusion. We included imaging data 15 from trial, 5 suffered haemorrhagic infarction type 1, 2 and had parenchymal haematoma 1. comparison patient image carried out comparing locations volume. parameters then optimised improve agreement clinical Finally, used investigate Based on model, we found perfusion reduced 5–16% onset. results in good showed 1% increase blood viscosity reduces 0.04% increases volume 10.35% baseline, pressure 0.80% 4.73% baseline. These indicate increased glucose hypertension (among other factors) both appear lead higher This enabling us bridge gap between data, provides first prediction assessment.

Language: Английский

Mathematical modelling of haemorrhagic transformation in the human brain DOI Creative Commons
Xi Chen, Jiayu Wang,

Katinka R. van Kranendonk

et al.

Applied Mathematical Modelling, Journal Year: 2023, Volume and Issue: 121, P. 96 - 110

Published: April 28, 2023

Haemorrhagic transformation (HT) is one of the most common complications after ischaemic stroke. HT can be result stroke progression or a complication reperfusion treatment for The aim this study to apply previously proposed mathematical model within computational whole brain determine factors that affect severity HT. In addition, these simulations are directly compared with neuroimaging data. MR CLEANNO IV trial assessed effect endovascular therapy (EVT) alone intravenous alteplase (IVT) followed by EVT patients acute due anterior circulation large vessel occlusion. We included imaging data 15 from trial, 5 suffered haemorrhagic infarction type 1, 2 and had parenchymal haematoma 1. comparison patient image carried out comparing locations volume. parameters then optimised improve agreement clinical Finally, used investigate Based on model, we found perfusion reduced 5–16% onset. results in good showed 1% increase blood viscosity reduces 0.04% increases volume 10.35% baseline, pressure 0.80% 4.73% baseline. These indicate increased glucose hypertension (among other factors) both appear lead higher This enabling us bridge gap between data, provides first prediction assessment.

Language: Английский

Citations

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