Context-invariant beliefs are supported by dynamic reconfiguration of single unit functional connectivity in prefrontal cortex DOI Creative Commons
Jean‐Paul Noel, Edoardo Balzani, Cristina Savin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 31, 2023

Abstract Natural behaviors occur in closed action-perception loops and are supported by dynamic flexible beliefs abstracted away from our immediate sensory milieu. How this real-world flexibility is instantiated neural circuits remains unknown. Here we have macaques navigate a virtual environment primarily leveraging (optic flow) signals, or more heavily relying on acquired internal models. We record single-unit spiking activity simultaneously the dorsomedial superior temporal area (MSTd), parietal 7a, dorso-lateral prefrontal cortex (dlPFC). Results show that while animals were able to maintain adaptive task-relevant regardless of context, fine-grain statistical dependencies between neurons, particularly 7a dlPFC, dynamically remapped with changing computational demands. In but not destroying these abolished area’s ability for cross-context decoding. Lastly, correlation analyses suggested unit-to-unit couplings less they did so MSTd, population codes behavior impacted loss evidence. conclude functional connectivity neurons maintains stable code context-invariant during naturalistic loops.

Language: Английский

Context-invariant beliefs are supported by dynamic reconfiguration of single unit functional connectivity in prefrontal cortex of male macaques DOI Creative Commons
Jean‐Paul Noel, Edoardo Balzani, Cristina Savin

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 9, 2024

Abstract Natural behaviors occur in closed action-perception loops and are supported by dynamic flexible beliefs abstracted away from our immediate sensory milieu. How this real-world flexibility is instantiated neural circuits remains unknown. Here, we have male macaques navigate a virtual environment primarily leveraging (optic flow) signals, or more heavily relying on acquired internal models. We record single-unit spiking activity simultaneously the dorsomedial superior temporal area (MSTd), parietal 7a, dorso-lateral prefrontal cortex (dlPFC). Results show that while animals were able to maintain adaptive task-relevant regardless of context, fine-grain statistical dependencies between neurons, particularly 7a dlPFC, dynamically remapped with changing computational demands. In but not destroying these abolished area’s ability for cross-context decoding. Lastly, correlational analyses suggested unit-to-unit couplings less they did so MSTd, population codes behavior impacted loss evidence. conclude functional connectivity neurons stable code context-invariant during naturalistic behavior.

Language: Английский

Citations

1
Context-invariant beliefs are supported by dynamic reconfiguration of single unit functional connectivity in prefrontal cortex DOI Creative Commons
Jean‐Paul Noel, Edoardo Balzani, Cristina Savin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 31, 2023

Abstract Natural behaviors occur in closed action-perception loops and are supported by dynamic flexible beliefs abstracted away from our immediate sensory milieu. How this real-world flexibility is instantiated neural circuits remains unknown. Here we have macaques navigate a virtual environment primarily leveraging (optic flow) signals, or more heavily relying on acquired internal models. We record single-unit spiking activity simultaneously the dorsomedial superior temporal area (MSTd), parietal 7a, dorso-lateral prefrontal cortex (dlPFC). Results show that while animals were able to maintain adaptive task-relevant regardless of context, fine-grain statistical dependencies between neurons, particularly 7a dlPFC, dynamically remapped with changing computational demands. In but not destroying these abolished area’s ability for cross-context decoding. Lastly, correlation analyses suggested unit-to-unit couplings less they did so MSTd, population codes behavior impacted loss evidence. conclude functional connectivity neurons maintains stable code context-invariant during naturalistic loops.

Language: Английский

Citations

1