Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans
Nature Reviews Genetics,
Journal Year:
2023,
Volume and Issue:
25(1), P. 46 - 60
Published: July 25, 2023
Language: Английский
Anticonvulsant effects of novel and repurposed drugs on docetaxel-induced neuropathy in C. elegans
Paola Gonzalez-Lerma,
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Crystal Lloyd,
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Scarlet J. Park
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et al.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 7, 2025
Abstract
Chemotherapeutic
agents
used
for
most
common
cancers
are
frequently
associated
with
neurotoxicity,
which
often
include
debilitating
side
effects
such
as
seizures.
Docetaxel,
one
of
the
widely
and
effectively
chemotherapeutic
drugs,
is
an
array
symptoms
referred
to
Docetaxel-Induced
Peripheral
Neuropathies
(DIPNs),
including
acute
or
chronic
In
this
study,
we
use
electroconvulsive
assay
model
DIPN-related
seizures
in
C.
elegans.
We
show
that
exposing
nematodes
docetaxel
increases
time-to-recovery
from
seizure.
Screening
compounds
protect
seizure-like
behaviors
induced
by
exposure
docetaxel,
find
sildenafil
citrate,
a
PDE-5
inhibitor,
novel
bicyclic
bridge
compound,
Resveramorph-3
(RVM-3),
both
effective
at
rescuing
animals
The
results
demonstrate
citrate
RVM-3
potential
candidates
mitigating
neurological
deficits
resulting
DIPNs.
Language: Английский