Anticonvulsant effects of novel and repurposed drugs on docetaxel-induced neuropathy in C. elegans DOI

Paola Gonzalez-Lerma,

Crystal Lloyd,

Scarlet J. Park

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Chemotherapeutic agents used for most common cancers are frequently associated with neurotoxicity, which often include debilitating side effects such as seizures. Docetaxel, one of the widely and effectively chemotherapeutic drugs, is an array symptoms referred to Docetaxel-Induced Peripheral Neuropathies (DIPNs), including acute or chronic In this study, we use electroconvulsive assay model DIPN-related seizures in C. elegans. We show that exposing nematodes docetaxel increases time-to-recovery from seizure. Screening compounds protect seizure-like behaviors induced by exposure docetaxel, find sildenafil citrate, a PDE-5 inhibitor, novel bicyclic bridge compound, Resveramorph-3 (RVM-3), both effective at rescuing animals The results demonstrate citrate RVM-3 potential candidates mitigating neurological deficits resulting DIPNs.

Language: Английский

Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans DOI
Shinya Yamamoto, Oguz Kanca, Michael F. Wangler

et al.

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 25(1), P. 46 - 60

Published: July 25, 2023

Language: Английский

Citations

42
Anticonvulsant effects of novel and repurposed drugs on docetaxel-induced neuropathy in C. elegans DOI

Paola Gonzalez-Lerma,

Crystal Lloyd,

Scarlet J. Park

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Chemotherapeutic agents used for most common cancers are frequently associated with neurotoxicity, which often include debilitating side effects such as seizures. Docetaxel, one of the widely and effectively chemotherapeutic drugs, is an array symptoms referred to Docetaxel-Induced Peripheral Neuropathies (DIPNs), including acute or chronic In this study, we use electroconvulsive assay model DIPN-related seizures in C. elegans. We show that exposing nematodes docetaxel increases time-to-recovery from seizure. Screening compounds protect seizure-like behaviors induced by exposure docetaxel, find sildenafil citrate, a PDE-5 inhibitor, novel bicyclic bridge compound, Resveramorph-3 (RVM-3), both effective at rescuing animals The results demonstrate citrate RVM-3 potential candidates mitigating neurological deficits resulting DIPNs.

Language: Английский

Citations

0