Probiotic Fermentation of Astragalus membranaceus and Raphani Semen Ameliorates Cyclophosphamide-Induced Immunosuppression Through Intestinal Short-Chain Fatty Acid-Dependent or -Independent Regulation of B Cell Function

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 312 - 312

Published: March 19, 2025

Probiotic fermentation can promote the release of more effective components from traditional Chinese medicines (TCMs). Astragalus membranaceus (Fisch.) Bunge (A. membranaceus) and Raphani Semen are TCMs that have gained attention for their immunoenhancing activities. This study aimed to investigate effects underlying mechanisms probiotic-fermented A. (PROAS) in cyclophosphamide (CTX)-induced immunocompromised mice. Changes composition after by probiotic strains, including Bifidobacterium longum SD5219, Lactobacillus fermentum NCIMB5221, paracasei were identified using high-performance liquid chromatography. The immunostimulatory PROAS evaluated immunosuppressed mice 3 7 days CTX treatment. resulted changes major bioactive components. supplementation effectively restored intestinal integrity CTX-treated upregulating mRNA expression tight junction proteins. significantly ameliorated reduction spleen index number B lymphocytes caused treatment regulated secretion cytokines serum colon tissues. administration modulated gut microbial dysbiosis short-chain fatty acid (SCFA) content These results suggest enhances lymphocyte function increasing regulation microbiota produce high levels SCFA, repairs barrier damage induced CTX, promotes mucosal immunity.

Language: Английский

Dietary sulforaphane glucosinolate mitigates depression-like behaviors in mice with hepatic ischemia/reperfusion injury: A role of the gut–liver–brain axis

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 176, P. 129 - 139

Published: June 5, 2024

Language: Английский