Long live the host! Proteomic analysis reveals possible strategies for parasitic manipulation of its social host DOI Creative Commons
Juliane Hartke, Alejandro Ceron‐Noriega, Marah Stoldt

et al.

Molecular Ecology, Journal Year: 2023, Volume and Issue: 32(21), P. 5877 - 5889

Published: Oct. 5, 2023

Parasites with complex life cycles often manipulate the phenotype of their intermediate hosts to increase probability transmission definitive hosts. Infection Anomotaenia brevis, a cestode that uses Temnothorax nylanderi ants as hosts, leads multiple-fold extension host lifespan and changes in behaviour, morphology colouration. The mechanisms behind these are unknown, is whether increased longevity achieved through parasite manipulation. Here, we demonstrate releases proteins into its functions might explain observed changes. These parasitic make up substantial portion proteome hosts' haemolymph, thioredoxin peroxidase superoxide dismutase, two antioxidants, exhibited highest abundances among them. largest part secreted could not be annotated, indicating they either novel or severely altered during recent coevolution function We also detected shifts infection, particular an overabundance vitellogenin-like A infected ants, protein regulates division labour which behavioural Our results thus suggest different strategies employed by this host: secreting immediate influence on host's altering translational activity. findings highlight intricate molecular interplay required point potential signalling pathways genes involved parasite-host communication.

Language: Английский

Long live the host! Proteomic analysis reveals possible strategies for parasitic manipulation of its social host DOI Creative Commons
Juliane Hartke, Alejandro Ceron‐Noriega, Marah Stoldt

et al.

Molecular Ecology, Journal Year: 2023, Volume and Issue: 32(21), P. 5877 - 5889

Published: Oct. 5, 2023

Parasites with complex life cycles often manipulate the phenotype of their intermediate hosts to increase probability transmission definitive hosts. Infection Anomotaenia brevis, a cestode that uses Temnothorax nylanderi ants as hosts, leads multiple-fold extension host lifespan and changes in behaviour, morphology colouration. The mechanisms behind these are unknown, is whether increased longevity achieved through parasite manipulation. Here, we demonstrate releases proteins into its functions might explain observed changes. These parasitic make up substantial portion proteome hosts' haemolymph, thioredoxin peroxidase superoxide dismutase, two antioxidants, exhibited highest abundances among them. largest part secreted could not be annotated, indicating they either novel or severely altered during recent coevolution function We also detected shifts infection, particular an overabundance vitellogenin-like A infected ants, protein regulates division labour which behavioural Our results thus suggest different strategies employed by this host: secreting immediate influence on host's altering translational activity. findings highlight intricate molecular interplay required point potential signalling pathways genes involved parasite-host communication.

Language: Английский

Citations

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