Hypothalamic Vasopressin Neurons Enable Maternal Thermoregulatory Behaviors DOI Creative Commons
Zahra Adahman,

Rumi Ooyama,

Dinore B. Gashi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

ABSTRACT Newborns of many mammalian species are partial poikilotherms and require adult thermoregulatory care for survival. In mice, pup survival in cold cool ambient temperature depends on the ability caregivers to huddle pups bring them into a high-quality nest. It is therefore essential that mice adjust parental as function changes temperature. Here, we investigated how mouse maternal adapts range temperatures, from warm. We show affect several individual co-parenting behaviors both dams virgin female modulate activity vasopressin neurons. Furthermore, establish effects neurons depend part thermosensation, specifically TRPM8 sensor. Using trans-synaptic anterograde tracing whole-brain mapping, find paraventricular hypothalamic nucleus connect synaptically with temperature-responsive brain structures implicated care. then optogenetic activation projections central amygdala, structure activated by temperature, recapitulates behaviors. Our data provide biological mechanism behavior translational relevance reported association between ecosystem fluctuations variations human child neglect cases.

Language: Английский

The highly diverse antiphage defence systems of bacteria DOI
Héloïse Georjon, Aude Bernheim

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(10), P. 686 - 700

Published: July 17, 2023

Language: Английский

Citations

240
Inputs and Outputs of the Mammalian Circadian Clock DOI Creative Commons

Ashley N. Starnes,

Jeff R. Jones

Biology, Journal Year: 2023, Volume and Issue: 12(4), P. 508 - 508

Published: March 28, 2023

Circadian rhythms in mammals are coordinated by the central circadian pacemaker, suprachiasmatic nucleus (SCN). Light and other environmental inputs change timing of SCN neural network oscillator, which, turn, sends output signals that entrain daily behavioral physiological rhythms. While much is known about molecular, neuronal, properties itself, circuits linking outside world to rhythmic outputs understudied. In this article, we review our current understanding synaptic non-synaptic onto from SCN. We propose a more complete description connectivity needed better explain how nearly all behaviors processes generated determine how, mechanistically, these disrupted disease or lifestyle.

Language: Английский

Citations

37
Hypothalamic Vasopressin Neurons Enable Maternal Thermoregulatory Behaviors DOI Creative Commons
Zahra Adahman,

Rumi Ooyama,

Dinore B. Gashi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

ABSTRACT Newborns of many mammalian species are partial poikilotherms and require adult thermoregulatory care for survival. In mice, pup survival in cold cool ambient temperature depends on the ability caregivers to huddle pups bring them into a high-quality nest. It is therefore essential that mice adjust parental as function changes temperature. Here, we investigated how mouse maternal adapts range temperatures, from warm. We show affect several individual co-parenting behaviors both dams virgin female modulate activity vasopressin neurons. Furthermore, establish effects neurons depend part thermosensation, specifically TRPM8 sensor. Using trans-synaptic anterograde tracing whole-brain mapping, find paraventricular hypothalamic nucleus connect synaptically with temperature-responsive brain structures implicated care. then optogenetic activation projections central amygdala, structure activated by temperature, recapitulates behaviors. Our data provide biological mechanism behavior translational relevance reported association between ecosystem fluctuations variations human child neglect cases.

Language: Английский

Citations

0