Somatosensory cortex microstimulation modulates primary motor and ventral premotor cortex neurons with extensive spatial convergence and divergence DOI Creative Commons
Brandon M. Ruszala, Kevin A. Mazurek, Marc H. Schieber

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 7, 2023

Abstract Intracortical microstimulation (ICMS) is known to affect distant neurons transynaptically, yet the extent which ICMS pulses delivered in one cortical area modulate other areas remains largely unknown. Here we assessed how individual of multi-channel trains upper extremity representation macaque primary somatosensory (S1) neuron firing motor cortex (M1) and ventral premotor (PMv). S1-ICMS modulated majority units recorded both M1 PMv, producing more inhibition than excitation. Effects converged on PMv from extensive S1 territories. Conversely, effects a small region diverged wide territories PMv. The this direct modulation produced by multi-electrode like that used here may need be taken into account bidirectional brain-computer interfaces decode intended movements neural activity these areas. Significance Statement Although produce relatively little about affects We show patch diverge distributed widely conversely, each can affected converging much representation. Such complicate decoding intent or when artificial sensation via interfaces.

Language: Английский

Interleaved Multi-Contact Peripheral Nerve Stimulation to Enhance Reproduction of Tactile Sensation: A Computational Modeling Study DOI Creative Commons
Tanya M. Tebcherani, Kenneth A. Loparo, Farhad Kaffashi

et al.

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2024, Volume and Issue: 32, P. 2302 - 2313

Published: Jan. 1, 2024

Peripheral nerve stimulation (PNS) is an effective means to elicit sensation for rehabilitation of people with loss a limb or function. While most current PNS paradigms deliver through single electrode contacts each tactile percept, multi-contact extraneural electrodes offer the opportunity groups individually simultaneously. Multi-contact strategies could be advantageous in developing biomimetic recreate natural neural activity during touch, because they may able selectively recruit multiple distinct populations. We used computational models and optimization approaches develop novel paradigm that uses interleaved (IMC) approximate critical coding properties underlying touch. The IMC combines field shaping, which two are active simultaneously, pulse-by-pulse contact parameter variations throughout touch stimulus. show simulation results better code mimicry than created same techniques, steering via two-contact one-contact PNS. also existing paradigms, including prior Future clinical studies will determine if can improve naturalness usefulness sensory feedback those neurological disorders.

Language: Английский

Citations

2
Biomimetic stimulation patterns drive natural artificial touch percepts using intracortical microstimulation in humans DOI Creative Commons
Taylor E. Hobbs, Charles M. Greenspon, Ceci Verbaarschot

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Objective. Intracortical microstimulation (ICMS) of human somatosensory cortex evokes tactile percepts that people describe as originating from their own body, but are not always described feeling natural. It remains unclear whether stimulation parameters such amplitude, frequency, and spatiotemporal patterns across electrodes can be chosen to increase the naturalness these artificial percepts. Approach. In this study, we investigated biomimetic — ICMS reproduce essential features natural neural activity increased perceived ICMS-evoked sensations compared a non-biomimetic pattern in three with cervical spinal cord injuries. All participants had electrode arrays implanted cortices. Rather than qualitatively asking which felt more natural, directly residual percepts, delivered by mechanical indentation on sensate region hand, evoked were asked linear or most like indentation. Main Results. We show simple ICMS, modulated amplitude single electrode, was being reference 32% electrodes. also tested an advanced scheme captured dynamics cortical using co-modulated amplitudes frequencies four Here, for 75% groups. Finally, required less stimulus charge counterparts. Significance. conclude encoding schemes mimic naturally occurring activation feel actual touch schemes. This suggests key elements neuronal useful conceptual guide constrain large parameter space when designing future strategies.

Language: Английский

Citations

2
Intracortical microstimulation of human somatosensory cortex induces natural perceptual biases DOI Creative Commons
Charles M. Greenspon, Natalya Shelchkova, Taylor E. Hobbs

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(6), P. 1178 - 1185

Published: Oct. 15, 2024

Language: Английский

Citations

1
Intracortical microstimulation of human somatosensory cortex is sufficient to induce perceptual biases DOI Creative Commons
Charles M. Greenspon, Natalya Shelchkova, Taylor E. Hobbs

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 22, 2024

A bstract Time-order error, a psychophysical phenomenon in which the duration between successive stimuli alters perception, has been studied for decades by neuroscientists and psychologists. To date, however, locus of these effects is unknown. We use intracortical microstimulation somatosensory cortex humans as tool to bypass initial stages processing restrict possible locations that signals could be modified. find that, using both amplitude discrimination magnitude estimation paradigms, reliably evoked time-order errors across all participants. Points subjective equality were symmetrically shifted during experiments intensity stimulus was perceived being more intense when compared single trials experiments. The error reduced paradigms at longer inter-stimulus intervals. These results show direct activation primary sufficient induce errors.

Language: Английский

Citations

1
Somatosensory cortex microstimulation modulates primary motor and ventral premotor cortex neurons with extensive spatial convergence and divergence DOI Creative Commons
Brandon M. Ruszala, Kevin A. Mazurek, Marc H. Schieber

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 7, 2023

Abstract Intracortical microstimulation (ICMS) is known to affect distant neurons transynaptically, yet the extent which ICMS pulses delivered in one cortical area modulate other areas remains largely unknown. Here we assessed how individual of multi-channel trains upper extremity representation macaque primary somatosensory (S1) neuron firing motor cortex (M1) and ventral premotor (PMv). S1-ICMS modulated majority units recorded both M1 PMv, producing more inhibition than excitation. Effects converged on PMv from extensive S1 territories. Conversely, effects a small region diverged wide territories PMv. The this direct modulation produced by multi-electrode like that used here may need be taken into account bidirectional brain-computer interfaces decode intended movements neural activity these areas. Significance Statement Although produce relatively little about affects We show patch diverge distributed widely conversely, each can affected converging much representation. Such complicate decoding intent or when artificial sensation via interfaces.

Language: Английский

Citations

1