Antibody escape, the risk of serotype formation, and rapid immune waning: Modeling the implications of SARS-CoV-2 immune evasion DOI Creative Commons
Catherine M. Albright, Debra Van Egeren, Aditya Thakur

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(10), P. e0292099 - e0292099

Published: Oct. 18, 2023

As the COVID-19 pandemic progresses, widespread community transmission of SARS-CoV-2 has ushered in a volatile era viral immune evasion rather than much-heralded stability “endemicity” or “herd immunity.” At this point, an array strains rendered essentially all monoclonal antibody therapeutics obsolete and strongly undermined impact vaccinal immunity on transmission. In work, we demonstrate that escape resulting pre-existing is highly evolutionarily favored likely to cause waves short-term long-term, invading induce weak cross-immunity against may co-circulate with those strains. This would result formation serotypes increase disease burden, complicate control, raise potential for increases virulence. Less durable does not drive positive selection as trait, but such transmit at high levels if they establish. Overall, our results draw attention importance inter-strain driver trends early data predict trajectory pandemic.

Language: Английский

Antibody escape, the risk of serotype formation, and rapid immune waning: Modeling the implications of SARS-CoV-2 immune evasion DOI Creative Commons
Catherine M. Albright, Debra Van Egeren, Aditya Thakur

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(10), P. e0292099 - e0292099

Published: Oct. 18, 2023

As the COVID-19 pandemic progresses, widespread community transmission of SARS-CoV-2 has ushered in a volatile era viral immune evasion rather than much-heralded stability “endemicity” or “herd immunity.” At this point, an array strains rendered essentially all monoclonal antibody therapeutics obsolete and strongly undermined impact vaccinal immunity on transmission. In work, we demonstrate that escape resulting pre-existing is highly evolutionarily favored likely to cause waves short-term long-term, invading induce weak cross-immunity against may co-circulate with those strains. This would result formation serotypes increase disease burden, complicate control, raise potential for increases virulence. Less durable does not drive positive selection as trait, but such transmit at high levels if they establish. Overall, our results draw attention importance inter-strain driver trends early data predict trajectory pandemic.

Language: Английский

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