Delineating disorder-general and disorder-specific dimensions of psychopathology from functional brain networks in a developmental clinical sample
Developmental Cognitive Neuroscience,
Journal Year:
2023,
Volume and Issue:
62, P. 101271 - 101271
Published: June 19, 2023
The
interplay
between
functional
brain
network
maturation
and
psychopathology
during
development
remains
elusive.
To
establish
the
structure
of
its
neurobiological
mechanisms,
mapping
both
shared
unique
connectivity
patterns
across
developmental
clinical
populations
is
needed.
We
investigated
associations
resting-state
in
children
adolescents
aged
5-21
(n
=
1689).
Specifically,
we
used
partial
least
squares
(PLS)
to
identify
latent
variables
(LV)
symptom
scores
diagnostic
information.
also
each
diagnosis
specifically,
controlling
for
other
categories.
PLS
identified
five
significant
LVs
symptoms,
onto
hierarchy.
first
LV
resembled
a
general
factor,
followed
by
dimensions
internalising-
externalising,
neurodevelopment,
somatic
complaints,
thought
problems.
Another
with
data
revealed
one
LV,
resembling
cross-diagnostic
case-control
pattern.
diagnosis-specific
pattern
autism
spectrum
disorder
(ASD).
All
were
associated
distinct
connectivity.
These
largely
replicated
an
independent
sample
420)
from
same
dataset,
as
well
cohort
3504).
This
suggests
that
covariance
networks
supports
transdiagnostic
psychopathology.
Language: Английский
Testing the sensitivity of diagnosis‐derived patterns in functional brain networks to symptom burden in a Norwegian youth sample
Human Brain Mapping,
Journal Year:
2024,
Volume and Issue:
45(3)
Published: Feb. 15, 2024
Abstract
Aberrant
brain
network
development
represents
a
putative
aetiological
component
in
mental
disorders,
which
typically
emerge
during
childhood
and
adolescence.
Previous
studies
have
identified
resting‐state
functional
connectivity
(RSFC)
patterns
reflecting
psychopathology,
but
the
generalisability
to
other
samples
politico‐cultural
contexts
has
not
been
established.
We
investigated
whether
previously
cross‐diagnostic
case–control
autism
spectrum
disorder
(ASD)‐specific
pattern
of
RSFC
(discovery
sample;
aged
5–21
from
New
York
City,
USA;
n
=
1666)
could
be
validated
Norwegian
convenience‐based
youth
sample
(validation
9–25
Oslo,
Norway;
531).
As
test
generalisability,
we
if
these
diagnosis‐derived
were
sensitive
levels
symptom
burden
both
samples,
based
on
an
independent
measure
burden.
Both
ASD‐specific
across
samples.
Connectivity
significantly
associated
with
thematically
appropriate
dimensions
discovery
sample.
In
validation
sample,
showed
weak,
inverse
relationship
symptoms
conduct
problems,
hyperactivity
prosociality,
while
was
linked
symptoms.
Diagnosis‐derived
developmental
clinical
US
convenience
youth,
however,
they
health
Language: Английский
Power and reproducibility in the external validation of brain-phenotype predictions
Nature Human Behaviour,
Journal Year:
2024,
Volume and Issue:
8(10), P. 2018 - 2033
Published: July 31, 2024
Language: Английский
Childhood adversities characterize the heterogeneity in the brain pattern of individuals during neurodevelopment
Psychological Medicine,
Journal Year:
2024,
Volume and Issue:
54(10), P. 2599 - 2611
Published: March 21, 2024
Several
factors
shape
the
neurodevelopmental
trajectory.
A
key
area
of
focus
in
research
is
to
estimate
that
have
maximal
influence
on
brain
and
can
tip
balance
from
typical
atypical
development.
Language: Английский
Delineating disorder-general and disorder-specific dimensions of psychopathology from functional brain networks in a developmental clinical sample
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: March 31, 2023
Abstract
The
interplay
between
functional
brain
network
maturation
and
psychopathology
during
development
remains
elusive.
To
establish
the
structure
of
its
neurobiological
mechanisms,
mapping
both
shared
unique
connectivity
patterns
across
developmental
clinical
populations
is
needed.
We
investigated
associations
resting-state
in
children
adolescents
aged
5-21
(n=1689).
Specifically,
we
used
partial
least
squares
(PLS)
to
identify
latent
variables
(LV)
symptom
scores
diagnostic
information.
also
each
diagnosis
specifically,
controlling
for
other
categories.
PLS
identified
five
significant
LVs
symptoms,
onto
hierarchy.
first
LV
resembled
a
general
factor,
followed
by
dimensions
internalising-externalising,
neurodevelopment,
somatic
complaints,
thought
problems.
Another
with
data
revealed
one
LV,
resembling
cross-diagnostic
case-control
pattern.
diagnosis-specific
pattern
autism
spectrum
disorder
(ASD).
All
were
associated
distinct
connectivity.
These
largely
replicated
an
independent
sample
(n=420)
from
same
dataset,
as
well
cohort
(n
=
3504).
This
suggests
that
covariance
networks
supports
transdiagnostic
psychopathology.
Language: Английский
Testing the sensitivity of diagnosis-derived patterns in functional brain networks to symptom burden in a Norwegian youth sample
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 9, 2023
Abstract
Aberrant
brain
network
development
represents
a
putative
aetiological
component
in
mental
disorders,
which
typically
emerge
during
childhood
and
adolescence.
Previous
studies
have
identified
resting-state
functional
connectivity
(RSFC)
patterns
reflecting
psychopathology,
but
the
generalisability
to
other
samples
politico-cultural
contexts
has
not
been
established.
We
investigated
whether
previously
cross-diagnostic
case-control
autism
spectrum
disorder
(ASD)-specific
pattern
of
RSFC
(discovery
sample;
aged
5-21
from
New
York
City,
USA;
n=1666)
could
be
validated
Norwegian
convenience-based
youth
sample
(validation
9-25
Oslo,
Norway;
n=531).
As
test
generalisability,
we
if
these
diagnosis-derived
were
sensitive
levels
symptom
burden
both
samples,
based
on
an
independent
measure
burden.
Both
ASD-specific
across
samples.
Connectivity
significantly
associated
with
thematically
appropriate
dimensions
discovery
sample.
In
validation
sample,
showed
weak,
inverse
relationship
symptoms
conduct
problems,
hyperactivity,
prosociality,
while
was
linked
symptoms.
Diagnosis-derived
developmental
clinical
US
convenience
youth,
however,
they
health
Language: Английский