COVID-19 and COVID-19 Vaccine in Japan—A Review from a General Physician's Perspective DOI Open Access
Hiroshi Kusunoki

Published: May 26, 2023

More than 3 years have passed since the emergence of COVID-19. On May 8, 2023, COVID-19 in Japan was downgraded to Category 5 by Infectious Disease Control Law. In Japan, at beginning pandemic 2020, cases infection and deaths from severe disease were few compared with those Western countries. However, medical field, screening for given top priority, resulting confusion proving disadvantageous many patients, also overreaction as most important issue society can be attributed largely statements infectious experts. addition, mRNA vaccine emerged 2021, population vaccinated up two times within a short period less 1 year because experts strongly promoted vaccination. After 2022, when vaccination progressed, Omicron strain, which is an attenuated became mainstay SARS-CoV-2, number decreased significantly; however, infected people increased dramatically instead. A significant portion thought hybrid immunity due plus natural maintains high antibody titers. Henceforth, additional should preferentially who will benefit it. Conversely, measures against caused serious damage economy society. Policies that not only address countermeasures infection, but encompass whole are necessary.

Language: Английский

Longitudinal Changes in IgG-Type SARS-CoV-2 Antibody Titers after COVID-19 Vaccination and a Prominent Increase in Antibody Titers When Infected after Vaccination DOI Creative Commons
Hiroshi Kusunoki,

Michiko Ohkusa,

Rie Iida

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(4), P. 860 - 860

Published: April 17, 2023

Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody titers level and duration of elevated levels are considered important indicators for confirming the efficacy disease 2019 (COVID-19) vaccines. The objective this study was to demonstrate changes in after second third doses COVID-19 vaccine, determine cases spontaneous infection with SARS-CoV-2 vaccination. Materials Methods: From June 2021 February 2023, IgG-type were measured 127 participants, including 74 outpatients 53 members staff, at Osaka Dental University Hospital (64 males 63 females, mean age 52.3 ± 19.0 years). Results: Consistent previous reports, titer decreased time, not only dose but also vaccine if there no infection. We confirmed that booster vaccination effective increasing titer. A total 21 natural infections observed administering two or more vaccine. Thirteen these patients had post-infection exceeding 40,000 AU/mL, some continued maintain tens thousands AU/mL even than 6 months passed since Conclusions: rise against novel longitudinal follow-up larger studies is warranted.

Language: Английский

Citations

8
COVID-19 and the COVID-19 Vaccine in Japan—A Review from a General Physician’s Perspective DOI Creative Commons
Hiroshi Kusunoki

Pharmacoepidemiology, Journal Year: 2023, Volume and Issue: 2(3), P. 188 - 208

Published: June 21, 2023

More than 3 years have passed since the emergence of COVID-19. On 8 May 2023, COVID-19 in Japan was downgraded to Category 5 by Infectious Disease Control Law. In Japan, at beginning pandemic 2020, cases infection and deaths from severe disease were few compared with those Western countries. However, medical field, screening for given top priority, resulting confusion proving disadvantageous many patients. The overreaction as most important issue society can be attributed largely statements infectious experts. addition, mRNA vaccine emerged 2021, population vaccinated up two times within a short period less 1 year because experts strongly promoted vaccination. After 2022, when vaccination progressed Omicron strain, which is an attenuated became mainstay SARS-CoV-2, number decreased significantly; however, infected people increased dramatically instead. A significant portion thought hybrid immunity due plus natural maintains high antibody titer levels. Henceforth, additional should preferentially who will benefit it. Conversely, measures against caused serious damage economy society. Policies that not only address countermeasures infection, but also encompass whole, are necessary.

Language: Английский

Citations

7
Antibody Response after Homologous and Heterologous Prime–Boost COVID-19 Vaccination in a Bangladeshi Residential University Cohort DOI Creative Commons
Nihad Adnan, Md. Ahsanul Haq, Salma Akter

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(5), P. 482 - 482

Published: April 30, 2024

COVID-19 vaccination strategies, including heterologous prime–boost regimens and additional booster doses, aim to optimize immune responses. However, seroepidemiological studies on responses different vaccine types schedules remain limited. This study investigated antibody levels following homologous prime-and-boost in Bangladesh. In a cohort of 606 participants who received first/second/booster doses vaccines (AstraZeneca, Moderna, Pfizer-BioNTech, Sinopharm), anti-spike IgG anti-nucleocapsid were measured. Antibody titer variations with respect age, gender, intervals between prior infection status analyzed. mRNA elicited the highest after boosting. The AstraZeneca resulted sharp decline rate ~0.04 units per day. Second or significantly increased levels, especially males (p < 0.05). Older age correlated higher titers, likely reflecting previous infection, which was further confirmed by elevation levels. About 95.5% non-Sinopharm recipients positive, suggesting exposure exceeding self-reported infections (12.5%). boosting enhances humoral immunity over vector/inactivated vaccination. waning merits investigation across platforms.

Language: Английский

Citations

2
Current Status and Significance of Additional Vaccination with COVID-19 Vaccine in Japan—Considerations from Antibody Levels from Hybrid Immunity and Public Perceptions DOI Creative Commons
Hiroshi Kusunoki

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1413 - 1413

Published: Dec. 15, 2024

This report examines the evolving role of coronavirus disease 2019 (COVID-19) vaccination in Japan, especially light reduced public concern following reclassification COVID-19 as a Category 5 infectious May 2023. With over half population estimated to have hybrid immunity from prior infections and vaccinations, this evaluated necessity frequency additional booster doses. Despite strong recommendations Japanese medical societies continue vaccination, skepticism remains owing financial burdens, adverse reactions, perceived limited benefits frequent boosters. Studies on antibody responses revealed that individuals with maintain robust protection significantly elevated titers persist extended periods. Case studies indicated durable among who both been vaccinated experienced breakthrough infections, raising questions about need for uniform policies. also discusses newly approved replicon-type (self-amplifying) vaccines currently available only which generated professional debates regarding their efficacy safety. A more personalized approach takes into account titers, infection history, individual choices is recommended. Finally, underscores importance aligning policies scientific evidence sentiment optimize countermeasures Japan.

Language: Английский

Citations

0
COVID-19 and COVID-19 Vaccine in Japan—A Review from a General Physician's Perspective DOI Open Access
Hiroshi Kusunoki

Published: May 26, 2023

More than 3 years have passed since the emergence of COVID-19. On May 8, 2023, COVID-19 in Japan was downgraded to Category 5 by Infectious Disease Control Law. In Japan, at beginning pandemic 2020, cases infection and deaths from severe disease were few compared with those Western countries. However, medical field, screening for given top priority, resulting confusion proving disadvantageous many patients, also overreaction as most important issue society can be attributed largely statements infectious experts. addition, mRNA vaccine emerged 2021, population vaccinated up two times within a short period less 1 year because experts strongly promoted vaccination. After 2022, when vaccination progressed, Omicron strain, which is an attenuated became mainstay SARS-CoV-2, number decreased significantly; however, infected people increased dramatically instead. A significant portion thought hybrid immunity due plus natural maintains high antibody titers. Henceforth, additional should preferentially who will benefit it. Conversely, measures against caused serious damage economy society. Policies that not only address countermeasures infection, but encompass whole are necessary.

Language: Английский

Citations

1