Indirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories DOI Creative Commons
Shaghayegh Navabpour, Morgan B. Patrick,

Nour Omar

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0315564 - e0315564

Published: Dec. 23, 2024

Post-traumatic stress disorder (PTSD) is a severe anxiety that affects women more than men. About 30% of patients suffering from PTSD develop the by witnessing traumatic event happen to someone else. However, as focus has remained on those directly experiencing event, whether indirectly acquired fear memories underlie have same molecular signature are remains unknown. Here, using rodent indirect learning paradigm where one rat (observer) watches another (demonstrator) associate an auditory cue with foot shock, we found can be both males and females regardless sex or novelty (familiarity) demonstrator animal. behaviorally, responses resemble pseudoconditioning, behavioral response thought not represent learning. Despite this, unbiased proteomics, distinct protein degradation profiles in amygdala anterior cingulate cortex (ACC) relative which further differed significantly sex. Additionally, Egr2 c-fos expression retrosplenial observer animals resembled rats but was different pseudoconditioned rats. Together, these findings reveal sex-specific signatures differ pseudoconditioning. These data important implications for understanding neurobiology may bystander PTSD.

Language: Английский

Crocin facilitates the effect of fear extinction on freezing behavior and BDNF level in a rat model of fear-conditioning DOI

Marjan Mohamadian,

Alaleh Mostafaei,

Mehrsa Rahimi-Danesh

et al.

Learning and Motivation, Journal Year: 2025, Volume and Issue: 89, P. 102095 - 102095

Published: Jan. 11, 2025

Language: Английский

Citations

0
Rapamycin attenuates reconsolidation of a backwards-conditioned aversive stimuli in female mice DOI

J. Stewart Trask,

Phillip E. MacCallum,

Haley Rideout

et al.

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(3), P. 601 - 612

Published: Feb. 5, 2024

Language: Английский

Citations

0
Indirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories DOI Creative Commons
Shaghayegh Navabpour, Morgan B. Patrick,

Nour Omar

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0315564 - e0315564

Published: Dec. 23, 2024

Post-traumatic stress disorder (PTSD) is a severe anxiety that affects women more than men. About 30% of patients suffering from PTSD develop the by witnessing traumatic event happen to someone else. However, as focus has remained on those directly experiencing event, whether indirectly acquired fear memories underlie have same molecular signature are remains unknown. Here, using rodent indirect learning paradigm where one rat (observer) watches another (demonstrator) associate an auditory cue with foot shock, we found can be both males and females regardless sex or novelty (familiarity) demonstrator animal. behaviorally, responses resemble pseudoconditioning, behavioral response thought not represent learning. Despite this, unbiased proteomics, distinct protein degradation profiles in amygdala anterior cingulate cortex (ACC) relative which further differed significantly sex. Additionally, Egr2 c-fos expression retrosplenial observer animals resembled rats but was different pseudoconditioned rats. Together, these findings reveal sex-specific signatures differ pseudoconditioning. These data important implications for understanding neurobiology may bystander PTSD.

Language: Английский

Citations

0