Hierarchical behavior control by a single class of interneurons

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(47)

Published: Nov. 12, 2024

Animal behavior is organized into nested temporal patterns that span multiple timescales. This hierarchy believed to arise from a hierarchical neural architecture: Neurons near the top of are involved in planning, selecting, initiating, and maintaining motor programs, whereas those bottom act concert produce fine spatiotemporal activity. In Caenorhabditis elegans , on long timescale emerges ordered flexible transitions between different behavioral states, such as forward, reversal, turn. On short timescale, parts animal body coordinate fast rhythmic bending sequences directional movements. Here, we show Sublateral Anterior A (SAA), class interneurons enable cross-communication dorsal ventral head neurons, play dual role shaping dynamics SAA regulate stabilize activity during forward same neurons suppress spontaneous reversals facilitate reversal termination by inhibiting Ring Interneuron M (RIM), an integrating neuron helps maintain state. These results suggest feedback lower-level cell assembly higher-level command center essential for bridging at levels.

Language: Английский

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C. elegans wired and wireless connectome: insights into principles of nervous system structure and function

Journal of Biosciences, Journal Year: 2025, Volume and Issue: 50(1)

Published: March 12, 2025

Language: Английский

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An inhibitory acetylcholine receptor gates context dependent mechanosensory processing inC. elegans

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 27, 2024

SUMMARY An animal’s current behavior influences its response to sensory stimuli, but the molecular and circuit-level mechanisms of this context-dependent decision-making is not well understood. In nematode C. elegans , inhibitory feedback from turning associated neurons alter downstream mechanosensory processing gate stimuli depending on whether animal or moving forward [1–3]. Until now, specific receptors that mediate were known. We use genetic manipulations, single-cell rescue experiments high-throughput closed-loop optogenetic perturbations during reveal neuron receptor responsible for receiving inhibition altering sensorimotor processing. acetylcholine gated chloride channel comprised lgc-47 acc-1 expressed in RIM receives signals performs gating disrupts worm’s evoked reversal response.

Language: Английский

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A single neuron inC. elegansorchestrates multiple motor outputs through parallel modes of transmission

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: April 2, 2023

Animals generate a wide range of highly coordinated motor outputs, which allows them to execute purposeful behaviors. Individual neuron classes in the circuits that behavior have remarkable capacity for flexibility, as they exhibit multiple axonal projections, transmitter systems, and modes neural activity. How these multi-functional properties neurons enable generation behaviors remains unknown. Here we show HSN

Language: Английский

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Neural Sequences Underlying Directed Turning inC. elegans

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 11, 2024

Complex behaviors like navigation rely on sequenced motor outputs that combine to generate effective movement. The brain-wide organization of the circuits integrate sensory signals select and execute appropriate sequences is not well understood. Here, we characterize architecture neural control

Language: Английский

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