Sex differences in change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex DOI Open Access
Romain Durand-de Cuttoli, Orna Issler, Samantha Pedersen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Changing one's mind involves re-appraisals between past-costs versus future-value and may be altered in psychopathology. Long intergenic non-coding RNA LINC00473 medial prefrontal cortex (mPFC) can induce stress-resilience a sex-dependent manner, but its role cognition is unknown. We characterized decision-making behavior male female mice the neuroeconomic paradigm Restaurant Row following virus-mediated expression of mPFC. Mice foraged for food among varying temporal-costs subjective-value while on limited time-budget. Without affecting primary deliberative decisions, selectively influenced re-evaluative choices manner. This included changing how (i) cached value with passage time (ii) weighed prior mistakes, which underlie computational bases sensitivity to sunk costs regret. These findings suggest common function shared these processes reveal bridge molecular drivers psychological mechanisms underlying sex-specific proclivities negative rumination.

Language: Английский

Sex differences in change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex DOI Open Access
Romain Durand-de Cuttoli, Orna Issler, Samantha Pedersen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Changing one's mind involves re-appraisals between past-costs versus future-value and may be altered in psychopathology. Long intergenic non-coding RNA LINC00473 medial prefrontal cortex (mPFC) can induce stress-resilience a sex-dependent manner, but its role cognition is unknown. We characterized decision-making behavior male female mice the neuroeconomic paradigm Restaurant Row following virus-mediated expression of mPFC. Mice foraged for food among varying temporal-costs subjective-value while on limited time-budget. Without affecting primary deliberative decisions, selectively influenced re-evaluative choices manner. This included changing how (i) cached value with passage time (ii) weighed prior mistakes, which underlie computational bases sensitivity to sunk costs regret. These findings suggest common function shared these processes reveal bridge molecular drivers psychological mechanisms underlying sex-specific proclivities negative rumination.

Language: Английский

Citations

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